Patents by Inventor Toshio Kasama

Toshio Kasama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6852311
    Abstract: Ophthalmic ointments for treating infective eye diseases which are particularly effective against infective eye diseases caused by methicillin-resistant Staphylococcus aureus (MRSA) or methicillin-resistant Staphylococcus epidermidis (MRSE) and contain as the active ingredient from 0.01 to 5.0% of vancomycin hydrochloride. Compared with intravenous administration, topical administration of these ophthalmic ointments is accompanied with no problem of the occurrence of side effects such as renal toxicity and thus enables the maintenance of a therapeutically effective concentration.
    Type: Grant
    Filed: June 28, 2000
    Date of Patent: February 8, 2005
    Assignee: TOA Pharmaceutical Co., Ltd.
    Inventors: Toshio Kasama, Mitsuru Noto, Susumu Oguro, Isao Hanazome, Rena Tatekawa
  • Publication number: 20040109896
    Abstract: An ophthalmic aqueous suspension preparation to serve as a cure for corneal herpes infection contains 9-[(2-hydroxyethoxy)methyl]guanine as an active ingredient and exhibits an improved stability. Specifically, the ophthalmic aqueous suspension preparation contains 0.2 to 5% by weight of 9-[(2-hydroxyethoxy)methyl]guanine or a pharmaceutically acceptable salt thereof, 0.05 to 1% by weight of a partially saponified product of polyvinyl acetate, and 0.01 to 1% by weight of a nonionic surfactant and has a pH of 6 to 8. Preferably, the fine crystals have a short axis of 50 &mgr;m or less and a long axis of 70 &mgr;m or less in length and have a ratio of the long axis to the short axis of 10:1 or less.
    Type: Application
    Filed: February 2, 2004
    Publication date: June 10, 2004
    Inventors: Kouichi Saitoh, Yoko Kishimoto, Satoru Tokuyama, Susumu Oguro, Isao Hanazome, Tomoyuki Okamoto, Toshio Kasama
  • Patent number: 5637081
    Abstract: An anticoagulant composition for a blood dialysis circuit contains a fatty acid derivative in liquid form at ambient temperature, and an antioxidant. The antioxidant is contained in an amount of 0.0001 to 5.0 parts by weight relative to 100 parts by weight of the fatty acid derivative. An air trap chamber device for a blood dialysis circuit contains a vessel for storing blood dialysed by a dialysis unit, an inlet tube for introducing the blood treated with dialysis into a liquid in the vessel selected from the group consisting of a layer of the aforementioned anticoagulant composition, and the blood, a measurement unit for measuring the pressure of air in the vessel lying above the layer of the anticoagulant composition, an adjustment unit for adjusting the pressure of the air and an outlet tube for conducting the blood treated with dialysis out of the vessel.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: June 10, 1997
    Assignee: NOF Corporation
    Inventors: Yasuhisa Noguchi, Toshio Kasama
  • Patent number: 5509895
    Abstract: An anticoagulant composition for a blood dialysis circuit contains a fatty acid derivative in liquid form at ambient temperature, and an antioxidant. The antioxidant is contained in an amount of 0.0001 to 5.0 parts by weight relative to 100 parts by weight of the fatty acid derivative. An air trap chamber device for a blood dialysis circuit contains a vessel for storing blood dialysed by a dialysis unit, an inlet tube for introducing the blood treated with dialysis into a liquid in the vessel selected from the group consisting of a layer of the aforementioned anticoagulant composition, and the blood, a measurement unit for measuring the pressure of air in the vessel lying above the layer of the anticoagulant composition, an adjustment unit for adjusting the pressure of the air and an outlet tube for conducting the blood treated with dialysis out of the vessel.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: April 23, 1996
    Assignee: NOF Corporation
    Inventors: Yasuhisa Noguchi, Toshio Kasama
  • Patent number: 5421815
    Abstract: An anticoagulant composition for a blood dialysis circuit contains a fatty acid derivative in liquid form at ambient temperature, and an antioxidant. The antioxidant is contained in an amount of 0.0001 to 5.0 parts by weight relative to 100 parts by weight of the fatty acid derivative. An air trap chamber device for a blood dialysis circuit contains a vessel for storing blood dialysed by a dialysis unit, an inlet tube for introducing the blood treated with dialysis into a liquid in the vessel selected from the group consisting of a layer of the aforementioned anticoagulant composition, and the blood, a measurement unit for measuring the pressure of air in the vessel lying above the layer of the anticoagulant composition, an adjustment unit for adjusting the pressure of the air and an outlet tube for conducting the blood treated with dialysis out of the vessel.
    Type: Grant
    Filed: December 14, 1993
    Date of Patent: June 6, 1995
    Assignee: NOF Corporation
    Inventors: Yasuhisa Noguchi, Toshio Kasama
  • Patent number: 5093339
    Abstract: Pyrano[f]quinoline derivatives of the formula (I): ##STR1## wherein R.sub.1 and R.sub.2 represent hydrogen, hydroxyl group or a group of the formula: ##STR2## wherein n represents an integer from 1 to 4, R.sub.3 and R.sub.4 represent hydrogen or a lower alkyl group, and the broken lines in the rings represent that the bond between the carbon atoms at the 1- and 2-positions and the bond between the carbon atoms at the 9- and 10-positions may be double bonds, and pharmaceutical compositions containing the derivatives. The derivatives and compositions are useful as anti-thrombotic agents, cerebral circulation improving agents, hypotensive agents, anti-angina agents, anti-asthmatic agents, anti-ulcer agents and anti-PAF agents.
    Type: Grant
    Filed: August 14, 1989
    Date of Patent: March 3, 1992
    Assignee: Kodama Kabushiki Kaisha
    Inventors: Toshio Kasama, Kiyoshi Mayuzumi, Ryuji Monden, Kenji Tamaru