Abstract: A magnetic-field generator (10) is provided to be used in construction of a cell sheet (12), and include s a magnetic circuit assembly (24) configured to generate a magnetic field for the construction of the cell sheet (12) using magnetic force caused by the magnetic field wherein the magnetic force is substantially transverse to a plane defined by the cell sheet (12), and a power control system (44) configured to generate and control electric power to magnetically charge the magnetic circuit assembly (24) using the electric power.

Abstract: An agent for inhibiting the action of a target RNA based on RNA interference and ASO with a passenger strand and a guide strand for a target RNA, wherein both ends of double-stranded RNA formed pairing of the passenger strand and the guide strand are blunt ends, and one or two or more selected from the group consisting of the units represented by formula (1) and formula (2) below at the following positions (a) and (b): (a) 5? end side and 3? end side of the passenger strand, (b) 3? end side of the guide strand (in which X represents an oxygen atom or sulfur atom), (in which X represents an oxygen atom or sulfur atom).

Abstract: The diagnostic device disclosed in this application is a device for diagnosing liver condition. The diagnostic device comprises a nitric oxide sensor and an information output unit. The nitric oxide sensor can be brought into contact with hepatocytes making up the liver and detects the concentration of nitric oxide produced by the hepatocytes. The information output unit, based on the nitric oxide concentration detected by the nitric oxide sensor, outputs information for diagnosing the condition of the liver. The information output unit can, for example, output a graph showing the change over time in the nitric oxide concentration detected by the nitric oxide sensor.

Abstract: The present inventors found that NEK2 kinase (accession number NM_002497) is expressed specifically in tumor cells such as bile duct carcinoma cells and that repression of the expression of NEK2 kinase by the use of RNA interference method led to inhibition of the growth of the tumor cells. A cytostatic agent for bile duct carcinoma and others containing an oligoribonucleotide comprising a segment of bases identical or complementary to less than 30 consecutive bases of nucleotide sequence of SEQ ID NO: 1, which includes at least 19 consecutive nucleotides of bases 403-423, 507-527 or 989-1009 of SEQ ID NO: 1 (NEK2 gene), or double-stranded RNA composed of the oligoribonucleotides.