Patents by Inventor Toshio Nagase
Toshio Nagase has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10583217Abstract: There is provided an implant that is safe for the living body. An angular plate as the implant includes a bone supporting plate part and a blade part. The blade part is integrally formed with the bone supporting plate part, and extends from one end of the bone supporting plate part at a predetermined angle ? (0°<?<180°) relative to the bone supporting plate part. The angular plate is formed from a titanium-tantalum-based alloy containing tin. The angular plate is preferably formed from a titanium-tantalum-based alloy containing tin in which a Young's modulus is decreased by increasing the reduction ratio thereof.Type: GrantFiled: September 29, 2017Date of Patent: March 10, 2020Assignee: NIPPON PISTON RING CO., LTD.Inventors: Yoshiki Ishikawa, Yuki Kimura, Takasumi Kubo, Hiroshi Matsushima, Takashi Kawabata, Toshio Nagase
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Publication number: 20110094971Abstract: There are provided a treatment agent and a treatment method for physically solidifying an aqueous waste liquid such as a floor wax peeling polluted water and the like simply and also speedily. On an occasion when treating the aqueous waste liquid physically, the treatment agent added to this aqueous waste liquid includes a polymer water-absorbing agent and a dispersing agent which is mixed with a polymer water-absorbing agent in order to disperse this polymer water-absorbing agent in the aqueous waste liquid. By adding this treatment agent to the aqueous waste liquid, the whole of both the substances is solidified into an aggregate of a crushed sponge-like granular material having a size in a range of averagely 0.4 mm to 10 mm.Type: ApplicationFiled: June 13, 2009Publication date: April 28, 2011Applicant: Fuji Mentenir Co., Ltd.Inventors: Yasushi Joh, Toshio Nagase
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Patent number: 6777410Abstract: This invention relates to compounds represented by the general formula [I] wherein, R represents an azido group, etc., R1 and R2 are the same or different and represent hydrogen atoms, etc., R3 and R4 are the same or different and represent hydrogen atoms, etc., X1 represents an oxygen atom, etc., X2 represents an oxygen atom, etc., Y represents an oxygen atom, etc., and Z represents a condensed aryl group, etc., or a pharmaceutically acceptable salt thereof, preparation processes thereof, and an agent for treating diabetes, a prophylactic agent for chronic complications of diabetes or a drug against obesity, containing, as an effective ingredient, the compound or the pharmaceutically acceptable salt thereof.Type: GrantFiled: April 8, 2003Date of Patent: August 17, 2004Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Toshio Nagase, Tomoharu Iino, Yoshiyuki Sato, Teruyuki Nishimura, Jun-ichi Eiki
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Publication number: 20040053923Abstract: This invention relates to compounds represented by the general formula [I] 1Type: ApplicationFiled: April 8, 2003Publication date: March 18, 2004Applicant: Banyu Pharmaceutical Co., Ltd.Inventors: Toshio Nagase, Tomoharu Iino, Yoshiyuki Sato, Teruyuki Nishimura, Jun-Ichi Eiki
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Patent number: 6608098Abstract: This invention relates to compounds represented by the general formula [I] wherein, R represents an azido group, etc., R1 and R2 are the same or different and represent hydrogen atoms, etc., R3 and R4 are the same or different and represent hydrogen atoms, etc., X1 represents an oxygen atom, etc., X2 represents an oxygen atom, etc., Y represents an oxygen atom, etc., and Z represents a condensed aryl group, etc., or a pharmaceutically acceptable salt thereof, preparation processes thereof, and an agent for treating diabetes, a prophylactic agent for chronic complications of diabetes or a drug against obesity, containing, as an effective ingredient, the compound or the pharmaceutically acceptable salt thereof.Type: GrantFiled: February 25, 2002Date of Patent: August 19, 2003Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Toshio Nagase, Tomoharu Iino, Yoshiyuki Sato, Teruyuki Nishimura, Jun-ichi Eiki
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Patent number: 5976215Abstract: An iron-based powder mixture for powder metallurgy, comprising: an iron-based powder, and from 0.05 to 0.50% by weight of a thermoplastic resin powder which comprises 50% or more by weight of units of at least one monomer selected from the group consisting of acrylic esters, methacrylic esters, and aromatic vinyl compounds, and whose average primary particle size is from 0.03 to 5 .mu.m, whose average agglomeration particle size is from 5 to 50 .mu.m, and whose average molecular weight measured by the specific viscosity of a solution is from 30000 to 5000000.Type: GrantFiled: August 20, 1998Date of Patent: November 2, 1999Assignee: Kawasaki Steel CorporationInventors: Satoshi Uenosono, Yukiko Ozaki, Kuniaki Ogura, Toshio Nagase, Takeo Kobayashi
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Patent number: 5972272Abstract: An unsaturated polyester resin composition for molding comprising (A) an unsaturated polyester resin, (B) a thickening agent containing powder of a thermoplastic resin as the effective component thereof in an amount of 20 to 120 parts by weight per 100 parts by weight of the unsaturated polyester resin, (C) a liquid polymerizable monomer in an amount of 30 to 120 parts by weight per 100 parts by weight of the unsaturated polyester resin, and (D) a curing agent; SMC and BMC prepared by adding (E) a reinforcing material to the composition; and a process for molding the SMC and the BMC at a low temperature under a low pressure. The unsaturated polyester resin composition of the present invention can be converted into SMC in a short time. The obtained SMC has an excellent storage stability, can be molded at a low temperature under a low pressure, and provides a molded product exhibiting low shrinkage, excellent surface smoothness, a large strength, and a large modulus.Type: GrantFiled: December 26, 1996Date of Patent: October 26, 1999Assignee: Nippon Zeon Co., Ltd.Inventors: Toshio Nagase, Takeo Kobayashi, Atsushi Tsukamoto
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Patent number: 5714479Abstract: A heteroaromatic ring-fused cyclopentene derivative of the formula: ##STR1## wherein the variables are as defined in the specification; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: February 20, 1996Date of Patent: February 3, 1998Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Toshio Nagase, Toshiaki Mase, Takashi Hayama, Masaki Ihara, Masaru Nishikibe, Mitsuo Yano
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Patent number: 5691315Abstract: The invention relates to compounds which are antagonists of endothelin, to processes for their preparation, and to their use as pharmaceuticals. The compounds of the invention are Useful in the treatment of hypertension, pulmonary hypertension, Reynaud's disease, myocardial infarction, angina pectoris, acute renal failure, cerebral infarction, cerebral vasospasm, arteriosclerosis, asthma, endotoxin shock, endotoxin-induced multiple organ failure or disseminated intravascular coagulation, and/or cyclosporin-induced renal failure or hypertension.Type: GrantFiled: June 26, 1995Date of Patent: November 25, 1997Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano
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Patent number: 5686509Abstract: An adhesion-reinforcing composition for an epoxy resin adhesive which comprises a copolymer resin particle having been ion-crosslinked with a univalent or divalent metal cation, which particle is comprised of (i) a core ingredient composed of a polymer comprising diene monomer units and optional crosslinking monomer units and having a glass transition temperature not higher than -30.degree. C. and (ii) a shell ingredient composed of a copolymer having a glass transition temperature of at least 70.degree. C. and comprising acrylate or methacrylate monomer units and 0.01-20 wt. parts, per 100 wt. parts of the shell ingredient, of units of a radically polymerizable unsaturated carboxylic acid monomer having a carboxyl group and 3-8 carbon atoms; the core/shell weight ratio being 5/1-1/4. A composition comprising 100 wt. parts of an epoxy resin, 15-60 wt.Type: GrantFiled: November 22, 1995Date of Patent: November 11, 1997Assignee: Nippon Zeon Co., Ltd.Inventors: Akira Nakayama, Toshio Nagase, Tadashi Ashida, Masahiko Ohnishi
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Patent number: 5637179Abstract: A process for adhesion using an epoxy rein adhesive composition which comprises coating surfaces for adhesion with a two component epoxy resin adhesive composition prepared immediately before the coating by mixing a mixture containing (A) resin powder prepared by ionic crosslinking of resin particles by addition of a metal cation and (B) an epoxy resin with (C) a curing agent of a room temperature curing type for epoxy resins, bringing the coated surfaces for adhesion into contact with each other, and subsequently heating the surfaces for adhesion. The resin particle is constituted with (a) a core formed with a (meth)acrylate polymer and/or a diene polymer which has a glass transition temperature of -30.degree. C. or lower and (b) a shell formed with a copolymer of a (meth)acrylate monomer and a radical polymerizable unsaturated carboxylic acid monomer having carboxyl group and 3 to 8 carbon atoms which has a glass transition temperature of 70.degree. C. or higher.Type: GrantFiled: September 28, 1995Date of Patent: June 10, 1997Assignee: Nippon Zeon Co., Ltd.Inventors: Akira Nakayama, Toshio Nagase
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Patent number: 5614498Abstract: Peptides having the formula: ##STR1## inhibit the binding of endothelin to its ET.sub.B receptor and are useful in treating diseases associated with excess production or secretion of endothelin.Type: GrantFiled: September 16, 1992Date of Patent: March 25, 1997Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takeshi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano, Masaru Nishikibe
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Patent number: 5496928Abstract: Peptides having the formula: ##STR1## inhibit the binding of endothelin and are useful in treating diseases associated with excess production or secretion of endothelin.Type: GrantFiled: April 20, 1994Date of Patent: March 5, 1996Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano, Masaru Nishikibe
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Patent number: 5470833Abstract: Peptides having the formula: ##STR1## inhibit the binding of endothelin to its receptor and are useful in treating diseases associated with excess production or secretion of endothelin.Type: GrantFiled: March 14, 1994Date of Patent: November 28, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano
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Patent number: 5444152Abstract: Peptides having the formula ##STR1## inhibit the binding of endothelin to its receptor and are useful in treating diseases associated with excess production or secretion of endothelin.Type: GrantFiled: March 21, 1994Date of Patent: August 22, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Takehiro Fukami, Takashi Hayama, Kenji Niiyama, Toshio Nagase, Toshiaki Mase, Kagari Fujita, Masaki Ihara, Fumihiko Ikemoto, Mitsuo Yano
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Patent number: 5389620Abstract: A heteroaromatic ring-fused cyclopentene derivative of the formula: ##STR1## wherein the variables are as defined in the specification; or a pharmaceutically acceptable salt thereof.Type: GrantFiled: December 14, 1993Date of Patent: February 14, 1995Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Kiyofumi Ishikawa, Toshio Nagase, Toshiaki Mase, Takashi Hayama, Masaki Ihara, Masaru Nishikibe, Mitsuo Yano
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Patent number: 5352704Abstract: A guanidinobenzene derivative represented by the formula (I): ##STR1## wherein R.sup.1 represents a substituent selected from the group consisting of a phenyl group substituted by an amidino group and a naphthyl group substituted by an amidino group, and salt thereof; a process for the production thereof; and an antiviral pharmaceutical composition comprising the compound.Type: GrantFiled: October 20, 1992Date of Patent: October 4, 1994Assignee: Banyu Pharmaceutical Co., Ltd.Inventors: Akira Okuyama, Kyozo Naito, Hidetoshi Ogino, Toshio Nagase, Kiyofumi Ishikawa, Nobuo Tanaka
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Patent number: 5326373Abstract: There is provided a tubular connector to connect first and second fluid tubes wherein separately formed first and second tubular sections are jointed together with a built-in artificial valve in the inside fluid path.Type: GrantFiled: June 7, 1991Date of Patent: July 5, 1994Assignee: Nippon Zeon Co., Ltd.Inventor: Toshio Nagase
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Patent number: 5298542Abstract: An acrylic ester copolymer plastisol composition comprises (A) copolymer particles comprising, as the major components thereof, (a) 98 to 50 weight % of an alkyl acrylate unit having an alkyl group of 1 to 8 carbon atoms and/or an alkyl methacrylate unit having an alkyl group of 1 to 8 carbon atoms and (b) 2 to 50 weight % of a diene monomer unit, (B) a plasticizer and, optionally, (C) a vulcanizing agent. Another acrylic ester copolymer plastisol composition comprises (A) copolymer particles comprising an ionic crosslinked copolymer prepared by ionic crosslinking of a copolymer comprising, as the major components thereof, (a) 97 to 50 weight % of an alkyl acrylate unit having an alkyl group of 1 to 8 carbon atoms and/or an alkyl methacrylate unit having an alkyl group of 1 to 8 carbon atoms, (b) 2 to 40 weight % of a diene monomer unit and (c) 1 to 20 weight % of a radical polymerizable unsaturated carboxylic acid unit of 3 to 8 carbon atoms having a carboxyl group and (B) a plasticizer.Type: GrantFiled: November 25, 1992Date of Patent: March 29, 1994Assignee: Nippon Zeon Co., Ltd.Inventors: Eitaro Nakamura, Toshio Nagase, Akira Nakayama, Yutaka Kagoshima, Atsushi Tsukamoto
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Patent number: 5290857Abstract: An epoxy resin adhesive composition has excellent adhesive properties such as impact resistance, tensile shear strength and T-peel strength as well as excellent semi-gelling property. An epoxy resin adhesive composition comprising ionic crosslinking in a polymer utilized as the impact resistance modifier has not only excellent semi-gelling property and mechanical properties of cured products but also excellent storage stability for a long time and it is advantageously utilized when the application occasionally requires storage or standing of the material for one month to one year at the room temperature. The epoxy resin adhesive composition comprises an epoxy resin, a powder core/shell polymer and a heat activation type hardener for epoxy resins. The powder core/shell polymer is composed of a core comprising an acrylate polymer or a methacrylate polymer having a glass transition temperature of -30.degree. C.Type: GrantFiled: September 3, 1992Date of Patent: March 1, 1994Assignees: Nippon Zeon Co., Ltd., Nissan Motor Co., Ltd.Inventors: Tadashi Ashida, Masahiko Ohnishi, Toshio Nagase, Akira Nakayama