Patents by Inventor Toshio Nikaido

Toshio Nikaido has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8932641
    Abstract: The present invention provides a dried amnion which is dried with maintaining tissues of a raw amnion and can be easily stored for a prolonged period of time. An amnion which is dried with maintaining cells and tissues of a raw amnion can be produced by repeating a pressure-reducing operation and a pressure-recovery operation several times, the pressure-reducing operation comprising continuously heating a raw amnion placed in a treatment vessel by a far-infrared heater provided in the treatment vessel and reducing the pressure of the inside of the treatment vessel, and the pressure-recovery operation comprising recovering the reduced pressure of the inside of the treatment vessel with heating the amnion by microwaves irradiated from a microwave heating apparatus provided outside of the treatment vessel, and the amnion is characterized by retaining basement membranes and connective tissues which are constituents of the raw amnion.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: January 13, 2015
    Assignee: Amnos Co., Ltd.
    Inventors: Toshio Nikaido, Toshiko Yoshida, Motonori Okabe, Ayaka Toda, Kiyotaka Kitagawa, Masahiko Arakawa
  • Patent number: 8414929
    Abstract: The dried amniotic membrane is produced by drying a fresh amniotic membrane, which envelopes an embryo of an animal including human, and can be used as a substitute membrane for a membrane tissue in a living body; the dried amniotic membrane is dehydrated and dried so that the dried amniotic membrane can be stored in a dry air in a sterile state; when hydrated again by immersing in water or a buffer solution, the amniotic membrane still has an epithelial cell, a basement membrane and a connective tissue which constitute the fresh amniotic membrane. The dried amniotic membrane is useful as a medical substitute membrane for a membrane tissue in a living body such as a dura mater, a meninx, a pericardium, a pleura and a peritoneum.
    Type: Grant
    Filed: February 21, 2008
    Date of Patent: April 9, 2013
    Assignee: National University Corporation University of Toyama
    Inventors: Toshio Nikaido, Motonori Okabe, Toshiko Yoshida, Shunro Endo, Nakamasa Hayashi, Shigeru Saito
  • Publication number: 20100098743
    Abstract: An object is to overcome the disadvantages of a conventional lyophilized amniotic membrane or the like which causes damages in a cell membrane or an amniotic membrane tissue and is therefore not suitable for use as a substitute membrane for a membrane tissue in a living body, and to provide a novel medical substitute membrane composed of a dried amniotic membrane, which can be used as a substitute membrane for a membrane tissue in a living body. The dried amniotic membrane is produced by drying a fresh amniotic membrane, which envelopes an embryo of an animal including human, and can be used as a substitute membrane for a membrane tissue in a living body; the dried amniotic membrane is dehydrated and dried so that the dried amniotic membrane can be stored in a dry air in a sterile state; when hydrated again by immersing in water or a buffer solution, the amniotic membrane still has an epithelial cell, a basement membrane and a connective tissue which constitute the fresh amniotic membrane.
    Type: Application
    Filed: February 21, 2008
    Publication date: April 22, 2010
    Inventors: Toshio Nikaido, Motonori Okabe, Toshiko Yoshida, Shunro Endo, Nakamasa Hayashi, Shigeru Saito
  • Publication number: 20090258082
    Abstract: The present invention provides a dried amnion which is dried with maintaining tissues of a raw amnion and can be easily stored for a prolonged period of time. An amnion which is dried with maintaining cells and tissues of a raw amnion can be produced by repeating a pressure-reducing operation and a pressure-recovery operation several times, the pressure-reducing operation comprising continuously heating a raw amnion placed in a treatment vessel by a far-infrared heater provided in the treatment vessel and reducing the pressure of the inside of the treatment vessel, and the pressure-recovery operation comprising recovering the reduced pressure of the inside of the treatment vessel with heating the amnion by microwaves irradiated from a microwave heating apparatus provided outside of the treatment vessel, and the amnion is characterized by retaining basement membranes and connective tissues which are constituents of the raw amnion.
    Type: Application
    Filed: August 18, 2006
    Publication date: October 15, 2009
    Inventors: Toshio Nikaido, Toshiko Yoshida, Motonori Okabe, Ayaka Toda, Kiyotaka Kitagawa, Masahiko Arakawa