Patents by Inventor Toshiro Kobori

Toshiro Kobori has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Biotinylated and oxidized LDL receptor and advanced glycation end product receptor produced using genetically engineered silkworm
    Patent number: 11311002
    Abstract: The present invention pertains to a silkworm-type biotinylated CTLD14 or sRAGE and a method for manufacturing the same. One embodiment of the present invention provides a method for manufacturing biotinylated proteins, wherein the method includes A) a step for inserting a nucleic acid molecule for coding biotin ligase and protein in a coexpressable manner into a silkworm or a living organism that imparts sugar chains that are the same as the sugar chains of the silkworm, B) a step for causing the biotin ligase and protein to be expressed by disposing the silkworm or the living organism that imparts sugar chains that are the same as the sugar chains of the silkworm to conditions with which the nucleic acid molecule will carry out expression, and C) a step for administering biotin to the living organism and obtaining the biotinylated protein.
    Type: Grant
    Filed: October 1, 2015
    Date of Patent: April 26, 2022
    Assignee: National Agriculture and Food Research Organization
    Inventors: Sachiko Machida, Miyuki Kuramochi, Mayumi Kameyama, Mari Yamamoto, Toshiro Kobori, Hideki Sezutsu, Ken-ichiro Tatematsu
  • BIOTINYLATED AND OXIDIZED LDL RECEPTOR AND ADVANCED GLYCATION END PRODUCT RECEPTOR PRODUCED USING GENETICALLY ENGINEERED SILKWORM
    Publication number: 20170354129
    Abstract: The present invention pertains to a silkworm-type biotinylated CTLD14 or sRAGE and a method for manufacturing the same. One embodiment of the present invention provides a method for manufacturing biotinylated proteins, wherein the method includes A) a step for inserting a nucleic acid molecule for coding biotin ligase and protein in a coexpressable manner into a silkworm or a living organism that imparts sugar chains that are the same as the sugar chains of the silkworm, B) a step for causing the biotin ligase and protein to be expressed by disposing the silkworm or the living organism that imparts sugar chains that are the same as the sugar chains of the silkworm to conditions with which the nucleic acid molecule will carry out expression, and C) a step for administering biotin to the living organism and obtaining the biotinylated protein.
    Type: Application
    Filed: October 1, 2015
    Publication date: December 14, 2017
    Inventors: Sachiko Machida, Miyuki Kuramochi, Mayumi Kameyama, Mari Yamamoto, Toshiro Kobori, Hideki Sezutsu, Ken-ichiro Tatematsu