Patents by Inventor Toshiro Niki

Toshiro Niki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-galectin-9 antibody and methods of use thereof
    Patent number: 11912772
    Abstract: An antibody targeting Galectin-9 is provided as are methods of using the same treatment of chronic immune conditions such as infections, inflammatory diseases and cancer, in particular malignant mesothelioma.
    Type: Grant
    Filed: July 12, 2019
    Date of Patent: February 27, 2024
    Assignee: University of Hawaii
    Inventors: Lishomwa C. Ndhlovu, Toshiro Niki
  • ANTI-GALECTIN-9 ANTIBODY AND METHODS OF USE THEREOF
    Publication number: 20210324086
    Abstract: An antibody targeting Galectin-9 is provided as are methods of using the same treatment of chronic immune conditions such as infections, inflammatory diseases and cancer, in particular malignant mesothelioma.
    Type: Application
    Filed: July 12, 2019
    Publication date: October 21, 2021
    Inventors: Lishomwa C. NDHLOVU, Toshiro NIKI
  • REVERSAL OF LATENCY OF RETROVIRUSES WITH A GALECTIN PROTEIN
    Publication number: 20180153901
    Abstract: The present invention relates to the seminal discovery of methods of using recombinant galectin proteins to reverse HIV latency. Specifically, the present invention relates to the use of recombinant galectin-9 (rGal-9) to reactivate latent HIV, wherein the HIV is hypermutated rendering the virus replication incompetent. Further, rGal-9 induces the expression of APOBEC3 cytidine deaminases and NFkB pathway components and decreases histone deacetylase (HDAC) expression.
    Type: Application
    Filed: March 10, 2016
    Publication date: June 7, 2018
    Inventors: Satish K. Pillai, Mohamed Abdel-Mohsen, Leonard Chavez, Lishomwa Ndhlovu, Ravi Tandon, Toshiro Niki, Misuomi Harashima
  • GALECTIN-9-SECRETING CELL, AND PRODUCTION METHOD AND USE OF THE SAME
    Publication number: 20170010282
    Abstract: The object of the present invention is to provide a cell that can exhibit physiological activity based on galectin-9, a method for producing the cell, and use of the cell. In order to achieve the above object, the cell of the present invention contains galectin-9, and the galectin-9 is expressed on a cell surface.
    Type: Application
    Filed: July 22, 2016
    Publication date: January 12, 2017
    Inventors: Mitsuomi HIRASHIMA, Toshiro NIKI, Tomohiro ARIKAWA, Souichi OOMIZU, Takeshi KADOWAKI
  • Method for increasing the proportion of animal cells secreting galectin-9
    Patent number: 9528089
    Abstract: The object of the present invention is to provide a cell that can exhibit physiological activity based on galectin-9, a method for producing the cell, and use of the cell. In order to achieve the above object, the cell of the present invention contains galectin-9, and the galectin-9 is expressed on a cell surface.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: December 27, 2016
    Assignee: GALPHARMA CO., LTD.
    Inventors: Mitsuomi Hirashima, Toshiro Niki, Tomohiro Arikawa, Souichi Oomizu, Takeshi Kadowaki
  • Method for increasing the proportion of animal cells secreting galectin-9
    Patent number: 9493741
    Abstract: The object of the present invention is to provide a cell that can exhibit physiological activity based on galectin-9, a method for producing the cell, and use of the cell. In order to achieve the above object, the cell of the present invention contains galectin-9, and the galectin-9 is expressed on a cell surface.
    Type: Grant
    Filed: September 29, 2014
    Date of Patent: November 15, 2016
    Assignee: GALPHARMA CO., LTD.
    Inventors: Mitsuomi Hirashima, Toshiro Niki, Tomohiro Arikawa, Souichi Oomizu, Takeshi Kadowaki
  • GALECTIN-9-SECRETING CELL, AND PRODUCTION METHOD AND USE OF THE SAME
    Publication number: 20150093366
    Abstract: The object of the present invention is to provide a cell that can exhibit physiological activity based on galectin-9, a method for producing the cell, and use of the cell. In order to achieve the above object, the cell of the present invention contains galectin-9, and the galectin-9 is expressed on a cell surface.
    Type: Application
    Filed: September 29, 2014
    Publication date: April 2, 2015
    Inventors: Mitsuomi HIRASHIMA, Toshiro NIKI, Tomohiro ARIKAWA, Souichi OOMIZU, Takeshi KADOWAKI
  • GALECTIN-9-SECRETING CELL, AND PRODUCTION METHOD AND USE OF THE SAME
    Publication number: 20130323176
    Abstract: The object of the present invention is to provide a cell that can exhibit physiological activity based on galectin-9, a method for producing the cell, and use of the cell. In order to achieve the above object, the cell of the present invention contains galectin-9, and the galectin-9 is expressed on a cell surface.
    Type: Application
    Filed: December 9, 2011
    Publication date: December 5, 2013
    Inventors: Mitsuomi Hirashima, Toshiro Niki, Tomohiro Arikawa, Souichi Oomizu, Takeshi Kadowaki
  • Anti-fibrotic medicament
    Patent number: 5993845
    Abstract: Compounds of submicromolar concentrations of a histone deacetylase inhibitor, useful as anti-fibrotic agents. The compounds strongly inhibit three main features of myofibroblastic differentiation of cultured hepatic stellate cells and of skin fibroblasts: (1) synthesis of collagens type I and III, the predominant collagens in fibrosis of liver and other organs; (2) cellular proliferation; and (3) expression of smooth muscle .alpha.-actin, a marker for activated myofibroblasts. Preferred compounds include trichostatin A or a pharmaceutically acceptable salt thereof, and sodium butyrate.
    Type: Grant
    Filed: September 3, 1997
    Date of Patent: November 30, 1999
    Assignee: Vrije Universiteit Brussel
    Inventors: Albert Emmanuel Corneille Geerts, Toshiro Niki