Abstract: Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 ?m; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 ?m and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.

Abstract: Microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 ?m; microcrystals of (E)-8-(3,4-dimethoxystyryl)-1,3-diethyl-7-methyl-3,7-dihydro-1H-purine-2,6-dione having an average particle size of less than 50 ?m and a crystallinity of 20% or more or the like, which possess excellent solubility, stability, bioavailability, dispersing property in a pharmaceutical formulation; and the like are provided. A solid pharmaceutical formulation which is characterized by comprising the same is also provided.

Abstract: The present invention provides a method for producing erythritol comprising cultivating microorganisms, which produce erythritol, belonging to Trichosporonoides megachiliensis in a culture medium having a high saccharide concentration and then recovering the erythritol accumulated in the culture medium. According to the present invention, cultivation period for producing erythritol can be shortened remarkably, and saccharide-based erythritol yield is excellent. Moreover, a large amount of erythritol can be produced efficiently, without much cost, since the same effect can be confirmed in case of using a culture medium at high saccharide concentration.

Abstract: A method for producing erythritol comprising cultivating a strain of Trichosporonoides oedocephalis in a culture medium containing 20 to 50 w/v % of saccharides and then recovering the erythritol accumulated in the culture medium. A commercial large scale production of erythritol can be efficiently carried out by following this method.

Abstract: A mutant strain of Trichosporonoides oedocephalis whose saccharide-based erythritol yield, at a saccharide concentration of 30 w/v % or higher, but less than 60 w/v %, is higher than that in its parent strain and whose cell biomass cultured is less than that of its parent strain.