Patents by Inventor Toshiro Sakai

Toshiro Sakai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210346392
    Abstract: In a pharmaceutical composition for oral administration comprising 6-(4,4-dimethylcyclohexyl)-4-[(1,1-dioxo-1?6-thiomorpholin-4-yl)methyl]-2-methylthieno[2,3-d]pyrimidine or a pharmaceutically acceptable salt thereof, a stable pharmaceutical composition for oral administration with rapid drug dissolution properties is provided. The pharmaceutical composition for oral administration contains a water-swellable substance, which is a polymer compound obtained by condensation polymerization of ?-glucose, a polymer compound obtained by condensation polymerization of ?-glucose, or a polymer compound having a pyrrolidone functional group.
    Type: Application
    Filed: August 30, 2019
    Publication date: November 11, 2021
    Applicant: ASTELLAS PHARMA INC.
    Inventors: Ryo KOJIMA, Toshiro SAKAI, Ryota AZUMA, Marina TANAKA
  • Publication number: 20200321719
    Abstract: Provided is a terminal fitting comprising a substrate of an aluminum alloy having excellent strength and workability. A terminal fitting 10 comprises a substrate of an aluminum alloy containing 4.0 to 6.0 mass % of Mg and having 0.2% yield strength at 290 to 330 MPa. Preferably the breaking elongation of the aluminum alloy is 10% or greater and the average crystal particle diameter of the aluminum alloy is 10 ?m or smaller. Preferably the aluminum alloy further contains 0.4 to 1.8 mass % of Mn.
    Type: Application
    Filed: December 6, 2018
    Publication date: October 8, 2020
    Inventors: Toshiro SAKAI, Shigeru OGIHARA
  • Publication number: 20200146977
    Abstract: Provided is a pharmaceutical composition for oral administration in which the solubility and/or dissolution properties of enzalutamide are improved and supersaturation is maintained. Also provided is a pharmaceutical composition for oral administration in which the oral absorbability of enzalutamide is improved. The pharmaceutical composition for oral administration comprises enzalutamide and polyvinyl alcohol.
    Type: Application
    Filed: April 27, 2018
    Publication date: May 14, 2020
    Inventors: Yoshiaki Umemoto, Takatsune Yoshida, Sachie Namiki, Akira Takagi, Ryo Kojima, Toshiro Sakai, Shinsuke Oba, Hajime Aoki
  • Patent number: 10583087
    Abstract: Disclosed is a pharmaceutical composition for oral administration, comprising 1-{5-[(5-{[(2R)-2-ethylpyrrolidin-1-yl]methyl}-4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl)carbamoyl]pyrazin-2-yl}pyperidine-4-carboxylic acid, which is a compound having pH-dependent solubility, or a pharmaceutically acceptable salt thereof, and a cellulose derivative. In the pharmaceutical composition for oral administration, the solubility and absorbability of the drug are improved.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: March 10, 2020
    Assignee: ASTELLAS PHARMA INC.
    Inventors: Yumiko Suda, Toshiro Sakai, Ryo Kojima, Dal Oyama, Koji Nishimura, Kumi Naiki
  • Publication number: 20200060976
    Abstract: This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.
    Type: Application
    Filed: April 1, 2019
    Publication date: February 27, 2020
    Inventors: Douglas Alan Lorenz, Sanjay Konagurthu, Randy J. Wald, Jason A. Everett, Sheila Matz, Yuuki Takaishi, Toshiro Sakai, Ryousuke Irie, Shinsuke Oba, Hiroyasu Toyota, Koji Nishimura, Atsushi Kanbayashi
  • Patent number: 10548845
    Abstract: Disclosed is a pharmaceutical composition for oral administration, comprising 1-{5-[(5-{[(2R)-2-ethylpyrrolidin-1-yl]methyl}-4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl)carbamoyl]pyrazin-2-yl}pyperidine-4-carboxylic acid, which is a compound having pH-dependent solubility, or a pharmaceutically acceptable salt thereof, and a cellulose derivative. In the pharmaceutical composition for oral administration, the solubility and absorbability of the drug are improved.
    Type: Grant
    Filed: April 27, 2016
    Date of Patent: February 4, 2020
    Assignee: ASTELLAS PHARMA INC.
    Inventors: Yumiko Suda, Toshiro Sakai, Ryo Kojima, Dal Oyama, Koji Nishimura, Kumi Naiki
  • Publication number: 20190209476
    Abstract: This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.
    Type: Application
    Filed: July 24, 2018
    Publication date: July 11, 2019
    Inventors: Douglas Alan Lorenz, Sanjay Konagurthu, Randy J. Wald, Jason A. Everett, Sheila Matz, Yuuki Takaishi, Toshiro Sakai, Ryousuke Irie, Shinsuke Oba, Hiroyasu Toyota, Koji Nishimura, Atsushi Kanbayashi
  • Patent number: 10058536
    Abstract: To provide: (1) a modified release liquid (suspension) containing mirabegron, (2) a ready-to-suspend pharmaceutical composition containing mirabegron, and (3) a mirabegron-containing pharmaceutical composition that does not generate undissolved lumps, even when it is suspended at the time of use. The present invention relates to a pharmaceutical composition containing a complex of mirabegron or a pharmaceutically acceptable salt thereof with sodium polystyrene sulfonate.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: August 28, 2018
    Assignee: ASTELLAS PHARMA INC.
    Inventors: Seiji Takae, Toshiro Sakai, Yuki Kasashima, Yurina Ansei, Tsuyoshi Kiyota
  • Publication number: 20180116965
    Abstract: Disclosed is a pharmaceutical composition for oral administration, comprising 1-{5-[(5-{[(2R)-2-ethylpyrrolidin-1-yl]methyl}-4-[4-methoxy-3-(trifluoromethyl)phenyl]-1,3-thiazol-2-yl)carbamoyl]pyrazin-2-yl}pyperidine-4-carboxylic acid, which is a compound having pH-dependent solubility, or a pharmaceutically acceptable salt thereof, and a cellulose derivative. In the pharmaceutical composition for oral administration, the solubility and absorbability of the drug are improved.
    Type: Application
    Filed: April 27, 2016
    Publication date: May 3, 2018
    Applicant: ASTELLAS PHARMA INC.
    Inventors: Yumiko SUDA, Toshiro SAKAI, Ryo KOJIMA, Dal OYAMA, Koji NISHIMURA, Kumi NAIKI
  • Publication number: 20180036288
    Abstract: To provide: (1) a modified release liquid (suspension) containing mirabegron, (2) a ready-to-suspend pharmaceutical composition containing mirabegron, and (3) a mirabegron-containing pharmaceutical composition that does not generate undissolved lumps, even when it is suspended at the time of use. The present invention relates to a pharmaceutical composition containing a complex of mirabegron or a pharmaceutically acceptable salt thereof with sodium polystyrene sulfonate.
    Type: Application
    Filed: March 31, 2016
    Publication date: February 8, 2018
    Applicant: ASTELLAS PHARMA INC.
    Inventors: SEIJI TAKAE, TOSHIRO SAKAI, YUKI KASASHIMA, YURINA ANSEI, TSUYOSHI KIYOTA
  • Publication number: 20170224624
    Abstract: This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.
    Type: Application
    Filed: September 16, 2016
    Publication date: August 10, 2017
    Inventors: Douglas Alan Lorenz, Sanjay Konagurthu, Randy J. Wald, Jason A. Everett, Sheila Matz, Yuuki Takaishi, Toshiro Sakai, Ryousuke Irie, Shinsuke Oba, Hiroyasu Toyota, Koji Nishimura, Atsushi Kanbayashi
  • Publication number: 20170027910
    Abstract: This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.
    Type: Application
    Filed: February 8, 2016
    Publication date: February 2, 2017
    Inventors: Douglas Alan Lorenz, Sanjay Konagurthu, Randy J. Wald, Jason A. Everett, Sheila Matz, Yuuki Takaishi, Toshiro Sakai, Ryousuke Irie, Shinsuke Oba, Hiroyasu Toyota, Koji Nishimura, Atsushi Kanbayashi
  • Patent number: 9520107
    Abstract: Provided is a keyboard musical instrument such as an acoustic piano or an electronic piano having an appearance and design similar to an acoustic piano, in which a fall board is made of a resin plate-shaped body, and hollow portions are provided inside the plate-shaped body. In addition, the plate-shaped body includes a plate-shaped resin foamed plate portion, and the hollow portions are made of plural air bubbles contained inside the resin foamed plate portion.
    Type: Grant
    Filed: September 8, 2014
    Date of Patent: December 13, 2016
    Assignee: Yamaha Corporation
    Inventors: Tadaharu Kato, Toshiro Sakai
  • Publication number: 20150068382
    Abstract: Provided is a keyboard musical instrument such as an acoustic piano or an electronic piano having an appearance and design similar to an acoustic piano, in which a fall board is made of a resin plate-shaped body, and hollow portions are provided inside the plate-shaped body. In addition, the plate-shaped body includes a plate-shaped resin foamed plate portion, and the hollow portions are made of plural air bubbles contained inside the resin foamed plate portion.
    Type: Application
    Filed: September 8, 2014
    Publication date: March 12, 2015
    Inventors: TADAHARU KATO, Toshiro Sakai
  • Publication number: 20140378517
    Abstract: This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.
    Type: Application
    Filed: September 10, 2014
    Publication date: December 25, 2014
    Inventors: Douglas Alan Lorenz, Sanjay Konagurthu, Randy J. Wald, Jason A. Everett, Sheila Matz, Yuuki Takaishi, Toshiro Sakai, Ryousuke Irie, Shinsuke Oba, Hiroyasu Toyota, Koji Nishimura, Atsushi Kanbayashi
  • Publication number: 20140179749
    Abstract: This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.
    Type: Application
    Filed: September 11, 2013
    Publication date: June 26, 2014
    Applicants: BEND RESEARCH, ASTELLAS PHARMA INC., MEDIVATION PROSTATE THERAPEUTICS, INC.
    Inventors: Douglas Alan Lorenz, Sanjay Konagurthu, Randy J. Wald, Jason A. Everett, Sheila Matz, Yuuki Takaishi, Toshiro Sakai, Ryousuke Irie, Shinsuke Oba, Hiroyasu Toyota, Koji Nishimura, Atsushi Kanbayashi
  • Publication number: 20140100256
    Abstract: This disclosure provides formulations of enzalutamide and their use for treating hyperproliferative disorders.
    Type: Application
    Filed: September 11, 2013
    Publication date: April 10, 2014
    Applicants: BEND RESEARCH, ASTELLAS PHARMA INC., MEDIVATION PROSTATE THERAPEUTICS, INC.
    Inventors: Douglas Alan Lorenz, Sanjay Konagurthu, Randy J. Wald, Jason A. Everett, Sheila Matz, Yuuki Takaishi, Toshiro Sakai, Ryousuke Irie, Shinsuke Oba, Hiroyasu Toyota, Koji Nishimura, Atsushi Kanbayashi
  • Patent number: 8462910
    Abstract: A neutron reactor includes a neutron shield which is disposed outside a nuclear reactor core and adapted to absorb neutrons leaking from the core. The neutron shield includes a plurality of containers each of which contains a powdered neutron absorbing material and which are stacked with one another in a vertical direction, and a cladding tube which houses the containers. The neutron absorbing material is composed of B4C powder.
    Type: Grant
    Filed: July 13, 2009
    Date of Patent: June 11, 2013
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Takanari Inatomi, Toshiyuki Suzuki, Hiroshi Nakamura, Toshiro Sakai
  • Publication number: 20130137739
    Abstract: A solid dispersion comprising a poorly soluble pharmaceutical compound, such as 3-methoxy-1,5-bis(4-methoxyphenyl)-1H-1,2,4-triazole, which has excellent ease of handling and stability is provided. The solid dispersion comprises a polymeric carrier (for example, a polymer selected from a group consisting of polyvinylpyrrolidone and copolyvidone) and further comprising hydroxypropyl methylcellulose as desired.
    Type: Application
    Filed: May 27, 2011
    Publication date: May 30, 2013
    Inventors: Atsushi Sakurai, Kazuhiro Sako, Toshiro Sakai
  • Patent number: 8295425
    Abstract: A fast reactor having a reactivity control reflector has a reactor vessel in which a coolant is accommodated, a reactor core which is installed in the reactor vessel and dipped with the coolant, and a reflector installed outside of the reactor core so as to be movable in a vertical direction for controlling the reactivity of the reactor core. The reflector of the fast reactor has a lower neutron reflecting portion having a neutron reflection capability higher than that of the coolant and an upper cavity portion located above the neutron reflecting portion and having a neutron reflection capability lower than that of the coolant. The cavity portion is composed of a plurality of cylindrical hermetically-sealed vessels.
    Type: Grant
    Filed: May 15, 2008
    Date of Patent: October 23, 2012
    Assignee: Kabushiki Kaisha Toshiba
    Inventors: Toshiro Sakai, Takanari Inatomi, Hiroshi Nakamura, Kenjiro Fukamichi, Toshiyuki Suzuki, Katsushi Hasegawa, Yasushi Tsuboi, Makoto Kuramochi