Abstract: The invention provides a choleretic composition, a bile acid secretion-promoting composition and a therapeutic composition for cholestasis each comprising insulin-like growth factor I or an analog thereof as well as a method of promoting secretion of bile which comprises administering insulin-like growth factor I or an analog thereof, a method of promoting secretion of bile acids, and a method for therapy of cholestasis in mammals.

Abstract: A vascular permeability suppressant includes an oxaspirooctane derivative of the general formula (I): [wherein, R1 represents, for example, lower alkylcarbamoyl group or protected carbamoyl group, R2 represents lower alkoxyl group, and R3 represents the formula: or a pharmaceutically acceptable salt thereof, together with a pharmaceutically acceptable carrier. Particularly, for example, an agent that can prevent retention of carcinomatous pleural effusion or carcinomatous ascites.

Abstract: Novel clavulone derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 combine together to form a keto group or either one of R.sup.1 and R.sup.2 is hydrogen atom and another one of them is hydroxy or acetoxy group, R.sup.3 and R.sup.4 are the same or different and are each hydrogen atom or acetoxy group, n is 0 or 1, provided that when the C--C bond between 8 and 12 positions is double bond, n is 0, a, b, c, d and e are each an integer of 1 or 2, and the dotted line means that the C--C bond is a single bond or double bond, or a salt thereof, which have excellent anti-inflammatory activity and anti-tumor activity and hence are useful as an anti-inflammatory agent or anti-tumor agent.