Patents by Inventor Toshitaka Sato

Toshitaka Sato has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240218035
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Application
    Filed: February 1, 2024
    Publication date: July 4, 2024
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Patent number: 11548926
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: January 10, 2023
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Patent number: 11466065
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: October 11, 2022
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Publication number: 20220267393
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Application
    Filed: May 5, 2022
    Publication date: August 25, 2022
    Applicant: Eisai R&D Management Co., Ltd.
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Patent number: 11325960
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: May 10, 2022
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Patent number: 11168123
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: November 9, 2021
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Publication number: 20190062390
    Abstract: The present invention provides a method for producing active hepatocyte growth factor activator (HGFA) and active hepatocyte growth factor (HGF) without using animal serum. The present invention relates to a method for producing active HGFA without using animal serum. The method is characterized in that it comprises a step of obtaining a culture supernatant comprising pro-HGFA by culturing mammalian cells expressing inactive hepatocyte growth factor activator (pro-HGFA) in a medium without serum, and a step of adjusting the culture supernatant comprising pro-HGFA obtained in the above step to weakly acidic to convert pro-HGFA into active HGFA. The present invention also relates to a method for producing active HGF with HGFA produced by said method.
    Type: Application
    Filed: March 15, 2017
    Publication date: February 28, 2019
    Inventors: Masashi Shimizu, Toshitaka Sato, Yoshihisa Arita
  • Patent number: 8655973
    Abstract: A first unit and a second unit manage a plurality of devices (a first device), respectively. In addition, the first and second units, repeat to transmit a keep-alive packet and to confirm a response each other, and thus detect each other's malfunction. When the second unit malfunctions, the first unit detects the malfunction of the second unit and transmits a connection command to the connection unit. The connection unit connects a lower net Nia and a lower net Nib when receiving the connection command. Then, the first unit communicates with the first device as heretofore, and further communicates with a second device via the connection unit. Thus, even if a master unit malfunctions, the device management system can maintain to manage without stopping a management of a slave unit which had been managed by the master unit until then.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: February 18, 2014
    Assignee: Panasonic Corporation
    Inventors: Toshitaka Sato, Yuuki Kasai, Masayuki Amano, Tadashi Matsumoto
  • Patent number: 8493838
    Abstract: When the alternate unit detects the failure of the area unit, the alternate unit obtains the program corresponding to the program type of the area unit having the failure. The alternate unit sets the IP address of the area unit, and obtains the setting information from the management unit belonging to the area same as the area including the area unit having the failure. Then, the alternate unit collects the data from the units which previously communicate with the area unit having a failure and previously communicating with the area unit. The alternate unit performs the initialization and starts the management of the unit. Consequently, it is possible to continuously manage the sub unit being previously managed by the main unit, now having a failure, without stopping the management of the sub unit, even if the main unit is failed.
    Type: Grant
    Filed: April 24, 2009
    Date of Patent: July 23, 2013
    Assignee: Panasonic Corporation
    Inventors: Toshitaka Sato, Yuuki Kasai, Hideki Fujimura
  • Patent number: 8484329
    Abstract: A device management system has lighting device controlling units and measurement management units, each of which is disposed in each sub area. In addition, the lighting device controlling units and the measurement management units are configured to communicate with an area unit which is disposed in each sub area. The area unit is configured to communicate with the lighting device controlling units and the measurement management units via a communication packet. The area unit further has a router which is configured to prevent the communication packet from leaking to the communication network having an upper management device in the high hierarchy level. The area unit is configured to communicate with the upper management device through the router.
    Type: Grant
    Filed: August 6, 2008
    Date of Patent: July 9, 2013
    Assignee: Panasonic Corporation
    Inventors: Toshitaka Sato, Hideki Fujimura, Masayuki Amano, Yuuki Kasai
  • Publication number: 20120004739
    Abstract: A device management system has lighting device controlling units and measurement management units, each of which is disposed in each sub area. In addition, the lighting device controlling units and the measurement management units are configured to communicate with an area unit which is disposed in each sub area. The area unit is configured to communicate with the lighting device controlling units and the measurement management units via a communication packet. The area unit further has a router which is configured to prevent the communication packet from leaking to the communication network having an upper management device in the high hierarchy level. The area unit is configured to communicate with the upper management device through the router.
    Type: Application
    Filed: August 6, 2008
    Publication date: January 5, 2012
    Inventors: Toshitaka Sato, Hideki Fujimura, Masayuki Amano, Yuuki Kasai
  • Publication number: 20110047259
    Abstract: When the alternate unit detects the failure of the area unit, the alternate unit obtains the program corresponding to the program type of the area unit having the failure. The alternate unit sets the IP address of the area unit, and obtains the setting information from the management unit belonging to the area same as the area including the area unit having the failure. Then, the alternate unit collects the data from the units which previously communicate with the area unit having a failure and previously communicating with the area unit. The alternate unit performs the initialization and starts the management of the unit. Consequently, it is possible to continuously manage the sub unit being previously managed by the main unit, now having a failure, without stopping the management of the sub unit, even if the main unit is failed.
    Type: Application
    Filed: April 24, 2009
    Publication date: February 24, 2011
    Inventors: Toshitaka Sato, Yuuki Kasai, Hideki Fujimura
  • Publication number: 20110040847
    Abstract: A first unit 2A and a second unit 2B manage a plurality of devices (a first device 8a, 8b), respectively. In addition, the first and second units 2A, 2B repeat to transmit a keep-alive packet and to confirm a response each other, and thus detect each other's malfunction. When the second unit 2B malfunctions, the first unit 2A detects the malfunction of the second unit 2B and transmits a connection command to the connection unit 5. The connection unit 5 connects a lower net Nia and a lower net Nib when receiving the connection command. Then, the first unit 2A communicates with the first device 8a as heretofore, and further communicates with a second device 8b via the connection unit 5. Thus, even if a master unit malfunctions, the device management system can maintain to manage without stopping a management of a slave unit which had been managed by the master unit until then.
    Type: Application
    Filed: April 24, 2009
    Publication date: February 17, 2011
    Inventors: Toshitaka Sato, Yuuki Kasai, Masayuki Amano, Tadashi Matsumoto