Abstract: A multi-piece solid golf ball which comprises a core consisting of an inner layer core and an outer layer core and a cover layer for covering the core, wherein the diameter of the inner layer core is 20 to 35 mm, the thickness of the outer layer core is 2 to 11 mm, the Shore D hardness (A) of the surface of the inner layer core and the Shore D hardness (B) of the surface of the outer layer core satisfy relational expressions, 15≦(A)≦50, 35≦(B)≦70 and (A)≦(B), and the cover layer is made from a resin composition comprising 50 to 90 parts by weight of an ionomer resin and 50 to 10 parts by weight of diene-based rubber. This multi-piece solid golf ball is excellent in impact resilience, flying performance, shot feeling and durability.