Patents by Inventor Toshiya Hirayama
Toshiya Hirayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8609607Abstract: This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. Compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. Methods are provided for modulating an antimicrobial activity and for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.Type: GrantFiled: January 5, 2012Date of Patent: December 17, 2013Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Joel Moss, Rodney L. Levine, Akihiro Wada, Toshiya Hirayama, Gregorino Paone
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Publication number: 20120107336Abstract: This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. Compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. Methods are provided for modulating an antimicrobial activity and for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.Type: ApplicationFiled: January 5, 2012Publication date: May 3, 2012Inventors: Joel Moss, Rodney L. Levine, Akihiro Wada, Toshiya Hirayama, Gregorino Paone
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Patent number: 8106006Abstract: This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. Compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. Methods are provided for modulating an antimicrobial activity and for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.Type: GrantFiled: February 18, 2009Date of Patent: January 31, 2012Assignee: The United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Joel Moss, Rodney L. Levine, Akihiro Wada, Toshiya Hirayama, Gregorino Paone
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Publication number: 20090155293Abstract: This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. In one embodiment, compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. In one embodiment, a method is provided for modulating an antimicrobial activity. In another embodiment, a method if provided for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.Type: ApplicationFiled: February 18, 2009Publication date: June 18, 2009Inventors: Joel Moss, Rodney L. Levine, Akihiro Wada, Toshiya Hirayama, Gregorino Paone
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Patent number: 7511015Abstract: This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. In one embodiment, compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. In one embodiment, a method is provided for modulating an antimicrobial activity. In another embodiment, a method is provided for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.Type: GrantFiled: February 18, 2003Date of Patent: March 31, 2009Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Joel Moss, Rodney L. Levine, Akihiro Wada, Toshiya Hirayama, Gregorino Paone
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Publication number: 20080275109Abstract: A drug, quasi drug, food or drink product containing a proanthocyanidine derived from hop, hop bract or apple has the effect of neutralizing or attenuating a vacuolacting toxin produced by Helicobacter pylori, thus preventing, preventing recurrence or treating digestive diseases in which Helicobacter pylori participates, as well as killing Helicobacter pylori, while providing few side effects and being free of risk of the occurrence of a tolerant strain.Type: ApplicationFiled: March 3, 2008Publication date: November 6, 2008Applicants: Asahi Breweries, Ltd., Toshiya HIRAYAMA, Masatoshi NODAInventors: Kinnosuke YAHIRO, Motoyuki Tagashira, Toshiya Hirayama, Masatoshi Noda
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Publication number: 20070009619Abstract: The present invention provides a drug, a quasi drug, a food or drink product having an effect of preventing, preventing recurrence or treating digestive diseases that Helicobacter pylori participates, as well as an effect of killing Helicobacter pylori while showing little side effects and being free from any risk of the occurrence of a tolerant strain. The present invention provides a drug, a quasi drug, a food or drink product containing an effective ingredient proanthocyanidines having an effect of neutralizing (attenuating) a vacuolating toxin produced by Helicobacter pylori, particularly and preferably proanthocyanidines originated from immature apple fruit or hop bracts.Type: ApplicationFiled: October 4, 2004Publication date: January 11, 2007Applicants: Asahi Breweries, Ltd., Toshiya Hirayama, Masatoshi NodaInventors: Kinnosuke Yahiro, Motoyuki Tagashira, Toshiya Hirayama, Masatoshi Noda
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Publication number: 20060036083Abstract: This disclosure provides modified antimicrobial agents, for example modified defensin polypeptides. In one embodiment, compositions including a modified arginine residue, such as an ADP-ribosylated and/or ribosylated alpha defensin polypeptide, are provided. Also provided are methods of modulating an immune response using the modified defensin polypeptides. In one embodiment, a method is provided for modulating an antimicrobial activity. In another embodiment, a method if provided for inhibiting a cytotoxic activity. Also disclosed are methods for treating diseases in a subject that are associated with an immune response, such as inflammatory and pulmonary diseases, using the disclosed modified defensin polypeptides.Type: ApplicationFiled: February 18, 2003Publication date: February 16, 2006Inventors: Joel Moss, Rodney Levine, Akihiro Wada, Toshiya Hirayama, Gregorino Paone