Abstract: The cost for shot-peening is intended to be reduced. The method for shot-peening of the present invention comprises a first step for processing a work by shot-peening by projecting shots onto the work, and a second step for processing the work by shot-peening by projecting the shots onto the work at a speed for projecting the shots that is slower than the speed in the first step, wherein the second step uses the same shot-peening machine and same shots that have been used in the first step. By this method, an intended distribution of compressive residual stresses is obtained by the processes in the first and second steps and the surface roughness of the work is decreased by the process in the second step wherein the shots are projected at the speed that is slower than that in the first step. Further, no removal or supply of the shots and no re-setting of the conditions for the process that are related to the removal and supply of the shots are required.

Abstract: Provided herein are methods for treating or preventing chronic lymphocytic leukemia, comprising administering an effective amount of a Dihydropyrazino-Pyrazine Compound to a patient having chronic lymphocytic leukemia.

Abstract: Provided herein are methods for treating or preventing head and neck squamous cell carcinoma characterized by deletion of chromosome 11q22 or loss of ataxia telangiectasia mutated expression, comprising administering an effective amount of a dihydropyrazino-pyrazine to a patient having head and neck squamous cell carcinoma characterized by deletion of chromosome 11q22 or loss of ataxia telangiectasia mutated expression.

Abstract: Provided herein are methods for treating or preventing a cancer, comprising administering an effective amount of a Dihydropyrazino-Pyrazine Compound and an effective amount of an androgen receptor antagonist to a patient having a cancer.

Abstract: Provided herein are methods for treating or preventing prostate cancer, comprising administering an effective amount of a TOR kinase inhibitor to a patient having prostate cancer.

Abstract: Provided herein are methods for treating or preventing ETS overexpressing castration-resistant prostate cancer, comprising administering an effective amount of a TOR kinase inhibitor to a patient having ETS overexpressing castration-resistant prostate cancer.

Abstract: The present invention is to provide a method for shot peening for producing a compressive residual stress that exceeds 60% of the yield strength at 0.2% offset without using stress shot peening. Shot media are peened onto a processed steel that has an amount of retained austenite in a range between 5 to 30%, and any change in the amount of retained austenite is controlled to be in a range of 2 to 30% before and after shot peening to produce the compressive residual stress in the processed steel.

Abstract: The cost for shot-peening is intended to be reduced. The method for shot-peening of the present invention comprises a first step for processing a work by shot-peening by projecting shots onto the work, and a second step for processing the work by shot-peening by projecting the shots onto the work at a speed for projecting the shots that is slower than the speed in the first step, wherein the second step uses the same shot-peening machine and same shots that have been used in the first step. By this method, an intended distribution of compressive residual stresses is obtained by the processes in the first and second steps and the surface roughness of the work is decreased by the process in the second step wherein the shots are projected at the speed that is slower than that in the first step. Further, no removal or supply of the shots and no re-setting of the conditions for the process that are related to the removal and supply of the shots are required.

Abstract: The present invention is to provide a method for shot peening for producing a high compressive residual stress in a gas carburized steel that has a soft layer. In this method, a depth where the maximum compressive residual stress is generated is estimated and the hardness on the surface or near the surface is not used. The depth where the maximum compressive residual stress is generated is estimated by multiplying the depth where the maximum stress is generated under contact stresses caused by the collision of shot media by the constant K. A processed steel that comprises a gas carburized steel and that has a hardness at that depth that exceeds 750 HV is used. Shot media that have a hardness that is greater than that of the processed steels at that depth by 50 HV or more are shot onto the processed steels to produce a high compressive residual stress in the processed steels.

Abstract: The purposes of the present inventions are to provide a raw material for shot-peening materials wherein breaking a wire is prevented in obtaining a finished wire to improve the productivity, to provide a finished wire and a method of manufacturing shot-peening materials by which productivity is improved, and to provide shot-peening materials that are manufactured by that method. The finished wire, of which the area of carbides with a particle size of 2 ?m or less is 80% or more of the total area, is manufactured by the steps of wiredrawing a raw material to obtain a wire, and repeatedly annealing and cold-drawing the wire. The raw material for the shot-peening materials comprises, by mass %, 0.95-1.10% carbon, 0.15-0.30% silicon, 0.40% or less manganese, 0.020% or less phosphorus, 0.010% or less sulfur, 1.40-1.60% chromium, 0.0015% or less oxygen, and the remaining materials of iron and unavoidable impurities. The method of manufacturing the shot-peening materials uses that raw material.

Abstract: The genes the expression of which is reduced or disappeared in immortal cells including cancer cells are isolated, their DNA sequences are determined, the genes are expressed to produce cell proliferation inhibitory proteins, and the genes and the proteins are utilized as agents for diagnosis or treatment, including the genetic diagnosis of or the gene therapy of diseases such as cancer.

Abstract: The genes the expression of which is reduced or disappeared in immortal cells including cancer cells are isolated, their DNA sequences are determined, the genes are expressed to produce cell proliferation inhibitory proteins, and the genes and the proteins are utilized as agents for diagnosis or treatment, including the genetic diagnosis of or the gene therapy of diseases such as cancer.

Abstract: In order to facilitate communications in a cellular communication system wherein control signal contamination renders communication with the closest cell impossible, the transmission power of the closest cell is reduced to the point wherein communication between the mobile unit and a cell adjacent the closest one, is enabled.

Abstract: A method of selecting a radio base station (BS) in a mobile communication system adapting a plurality of voice coding methods is provided. This method reduces a probability of failure in allocating speech channel at the BS after having been selected. Each BS broadcasts the usage rate of the speech channel for each method through a control channel, in connection with speech channel groups which can be allocated. The MS selects a BS as a candidate to be connected, which is optimum in view of receiving state of the control channel and the usage rate of the speech channel, at the time of waiting state after having power put on or during hand-over operation.

Abstract: A system is provided for processing synchronization signals. A plurality of synchronization signals are received having different periods and different degrees of priority, and are used to generate a regenerated synchronization signal in response to clock pulses. A selector is used for selecting a selected synchronization signal, from among those received synchronization signals having a correct period. The selected synchronization signal is chosen based upon the different degrees of priority. A nonvolatile memory stores memorized synchronization signal and an allowable phase range. An address counter, which receives as an input a controllable initial value, counts the clock pulses to produce a clock count over a period of time, and to cause the nonvolatile memory to output the stored synchronization signal as a read-out synchronization signal and to output the stored allowable phase range as a read-out range, in response to the clock count.

Abstract: A system for use in a local switching center is provided for processing synchronization signals. A transmission sync signal is generated at the local switching center for transmission to a switching center of a higher hierarchy for looping back to the local switching center. The looped back sync signal has a propagation delay time with respect to the transmission sync signal. A time division switch produces clock pulses. A stored pattern is read out of a non-volatile memory according to an address value provided by an address counter which counts the clock pulses of the time division switch. A delay time is also read out of the non-volatile memory according to the same address value. A phase difference signal is produced by comparing the length of the propagation delay time with the delay time read out of the non-volatile memory.

Abstract: A mobile communication system provides different types of radio communications using a same mobile terminal service. One service area is provided by conventional base stations by which the mobile communication network is carried out, and another service area is provided by a fixed network terminal device, such as a cordless home phone connected in a public fixed communication network, and the mobile terminal device can be used in both service areas by switching over internal call circuit appropriately. On the other hand, a call directed to the mobile terminal device is suitably routed to the mobile terminal device in either of the service areas by a terminal device switching circuit in the mobile communication systems having a database on which location information of the mobile terminal device are registered.

Abstract: For synchronization signals of zeroth and first series, a synchronization signal processing system comprises synchronization trunk device of the zeroth and the first series (77(0), 77(1)) for producing particular signals of the zeroth and the first series, respectively, and being exclusively operable in master and slave states.