Patents by Inventor Toshiyasu Imai

Toshiyasu Imai has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210205326
    Abstract: The present invention relates to a medicine for preventing or treating pain in nociceptive pain, inflammatory pain, or neuropathic pain, the medicine comprising, as an active ingredient, a compound having a P2X4 receptor antagonist action, a tautomer of the compound, a stereoisomer thereof, a pharmaceutically acceptable salt thereof, a hydrate thereof, or a solvate thereof. The medicine has no effect on driving or machine operation ability, has no effect on car driving ability, does not require any restriction to administration thereof to a patient engaging in operation of a dangerous machine including driving a car, or can be administered to a patient engaging in operation of a dangerous machine including driving a car.
    Type: Application
    Filed: September 3, 2019
    Publication date: July 8, 2021
    Applicant: NIPPON CHEMIPHAR CO., LTD.
    Inventor: Toshiyasu IMAI
  • Publication number: 20210121478
    Abstract: A medicament for preventive and/or therapeutic treatment of multiple sclerosis, especially a pain accompanying multiple sclerosis such as neuropathic pain, which contains a compound having a P2X4 receptor antagonist activity such as a compound represented by the general formula (IH), or a salt thereof, or a hydrate or solvate thereof as an active ingredient.
    Type: Application
    Filed: April 27, 2017
    Publication date: April 29, 2021
    Inventors: Toshiyasu IMAI, Toru KAWASAKI, Toru OGAWA, Kazuhide INOUE
  • Publication number: 20210000840
    Abstract: The present invention pertains to a medicament for preventing or treating cough, including, as an active ingredient, a compound having P2X4 receptor antagonistic action, a tautomer, stereoisomer, or pharmaceutically acceptable salt of the compound, or a hydrate or solvate thereof.
    Type: Application
    Filed: March 14, 2019
    Publication date: January 7, 2021
    Applicants: NIPPON CHEMIPHAR CO., LTD., HOSHI UNIVERSITY
    Inventors: Toshiyasu IMAI, Junzo KAMEI
  • Publication number: 20200223806
    Abstract: The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R1 and R2 represent hydrogen atom and the like, or R1 and R2 bind together to form a naphthalene ring and the like together with the benzene ring to which they bind, R3 and R4 represent hydrogen atom and the like, R5 represents hydrogen atom and the like, R6 and R7 represent hydrogen atom and the like, X represents C, CH or N, Y represents N, NH or C(?O), provided that when X is N, Y is not N or NH, and when X is C or CH, Y is not C(?O), Z represents oxygen atom or sulfur atom, A represents benzene ring and the like, B represents NHC(?O) and the like, D represents an atomic bond and the like, E represents an atomic bond and the like, G represents benzene which may be substituted and the like, and m represents an integer of 0 to 5) or a pharmacologically acceptable salt thereof, and a P2X4 receptor antagonist.
    Type: Application
    Filed: March 23, 2020
    Publication date: July 16, 2020
    Applicant: NIPPON CHEMIPHAR CO., LTD
    Inventors: Masatoshi USHIODA, Kunio KOBAYASHI, Daisuke SAITO, Shogo SAKUMA, Toshiyasu IMAI, Kazuhide INOUE
  • Patent number: 10633349
    Abstract: The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R1 and R2 represent hydrogen atom and the like, or R1 and R2 bind together to form a naphthalene ring and the like together with the benzene ring to which they bind, R3 and R4 represent hydrogen atom and the like, R5 represents hydrogen atom and the like, R6 and R7 represent hydrogen atom and the like, X represents C, CH or N, Y represents N, NH or C(?O), provided that when X is N, Y is not N or NH, and when X is C or CH, Y is not C(?O), Z represents oxygen atom or sulfur atom, A represents benzene ring and the like, B represents NHC(?O) and the like, D represents an atomic bond and the like, E represents an atomic bond and the like, G represents benzene which may be substituted and the like, and m represents an integer of 0 to 5) or a pharmacologically acceptable salt thereof, and a P2X4 receptor antagonist.
    Type: Grant
    Filed: March 16, 2018
    Date of Patent: April 28, 2020
    Assignee: NIPPON CHEMIPHAR CO., LTD
    Inventors: Masatoshi Ushioda, Kunio Kobayashi, Daisuke Saito, Shogo Sakuma, Toshiyasu Imai, Kazuhide Inoue
  • Patent number: 10472333
    Abstract: Compounds represented by the following general formula (I), which has a P2X4 receptor antagonistic activity (in the formula, R1, R2 and R3 represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, and the like, X represents C or N, Y represents N or C(?O), provided that when X is C, Y represents N, and when X is N, Y represents C(?O), the double line consisting of the solid line and the broken line represents a single bond or double bond, n represents an integer of 0 to 6, Z represents O, S, or an atomic bond, and A represents benzene ring, pyridine ring, and the like).
    Type: Grant
    Filed: July 19, 2018
    Date of Patent: November 12, 2019
    Assignees: NIPPON CHEMIPHAR CO., LTD., KYUSHU UNIVERSITY
    Inventors: Shogo Sakuma, Kunio Kobayashi, Masatoshi Ushioda, Toshiyasu Imai, Kazuhide Inoue
  • Publication number: 20190046539
    Abstract: A P2X4 receptor antagonist such as paroxetine, a diazepinedione derivative having the following formula (IX) is used as an agent for preventing or treating neuropathic pain associated with Guillain-Barré syndrome: wherein R1 is hydrogen, a C1-8 alkyl group, or the like; each of R2 and R3 is hydrogen, a C1-8 alkyl group, or the like; each of R4 and R5 is hydrogen or the like; and W is a five-membered or six-membered heterocyclic ring optionally having one or more substituents and comprising one to four nitrogen atoms as the members of the ring.
    Type: Application
    Filed: October 17, 2018
    Publication date: February 14, 2019
    Inventors: Toshiyasu IMAI, Toru KAWASAKI, Toru OGAWA, Kazuhide INOUE
  • Patent number: 10150744
    Abstract: The present invention relates to a compound represented by the following general formula (I), which has a P2X4 receptor antagonistic activity (in the formula, R1, R2 and R3 represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, and the like, X represents C or N, Y represents N or C(?O), provided that when X is C, Y represents N, and when X is N, Y represents C(?O), the double line consisting of the solid line and the broken line represents a single bond or double bond, n represents an integer of 0 to 6, Z represents O, S, or an atomic bond, and A represents benzene ring, pyridine ring, and the like).
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: December 11, 2018
    Assignees: NIPPON CHEMIPHAR CO., LTD, KYUSHU UNIVERSITY
    Inventors: Shogo Sakuma, Kunio Kobayashi, Masatoshi Ushioda, Toshiyasu Imai, Kazuhide Inoue
  • Publication number: 20180319752
    Abstract: Compounds represented by the following general formula (I), which has a P2X4 receptor antagonistic activity (in the formula, R1, R2 and R3 represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, and the like, X represents C or N, Y represents N or C(?O), provided that when X is C, Y represents N, and when X is N, Y represents C(?O), the double line consisting of the solid line and the broken line represents a single bond or double bond, n represents an integer of 0 to 6, Z represents O, S, or an atomic bond, and A represents benzene ring, pyridine ring, and the like).
    Type: Application
    Filed: July 19, 2018
    Publication date: November 8, 2018
    Applicants: NIPPON CHEMIPHAR CO., LTD., KYUSHU UNIVERSITY
    Inventors: Shogo SAKUMA, Kunio KOBAYASHI, Masatoshi USHIODA, Toshiyasu IMAI, Kazuhide INOUE
  • Publication number: 20180201587
    Abstract: The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R1 and R2 represent hydrogen atom and the like, or R1 and R2 bind together to form a naphthalene ring and the like together with the benzene ring to which they bind, R3 and R4 represent hydrogen atom and the like, R5 represents hydrogen atom and the like, R6 and R7 represent hydrogen atom and the like, X represents C, CH or N, Y represents N, NH or C(?O), provided that when X is N, Y is not N or NH, and when X is C or CH, Y is not C(?O), Z represents oxygen atom or sulfur atom, A represents benzene ring and the like, B represents NHC(?O) and the like, D represents an atomic bond and the like, E represents an atomic bond and the like, G represents benzene which may be substituted and the like, and m represents an integer of 0 to 5) or a pharmacologically acceptable salt thereof, and a P2X4 receptor antagonist.
    Type: Application
    Filed: March 16, 2018
    Publication date: July 19, 2018
    Applicant: NIPPON CHEMIPHAR CO., LTD
    Inventors: Masatoshi USHIODA, Kunio KOBAYASHI, Daisuke SAITO, Shogo SAKUMA, Toshiyasu IMAI, Kazuhide INOUE
  • Patent number: 9969700
    Abstract: The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R1 and R2 represent hydrogen atom and the like, or R1 and R2 bind together to form a naphthalene ring and the like together with the benzene ring to which they bind, R3 and R4 represent hydrogen atom and the like, R5 represents hydrogen atom and the like, R6 and R7 represent hydrogen atom and the like, X represents C, CH or N, Y represents N, NH or C(?O), provided that when X is N, Y is not N or NH, and when X is C or CH, Y is not C(?O), Z represents oxygen atom or sulfur atom, A represents benzene ring and the like, B represents NHC(?O) and the like, D represents an atomic bond and the like, E represents an atomic bond and the like, G represents benzene which may be substituted and the like, and m represents an integer of 0 to 5) or a pharmacologically acceptable salt thereof, and a P2X4 receptor antagonist.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: May 15, 2018
    Assignee: NIPPON CHEMIPHAR CO., LTD.
    Inventors: Masatoshi Ushioda, Kunio Kobayashi, Daisuke Saito, Shogo Sakuma, Toshiyasu Imai, Kazuhide Inoue
  • Patent number: 9873683
    Abstract: The present invention relates to a compound represented by the following general formula (II), wherein, in the formula, R1a to R6a represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, and the like, Xa represents C or N, Ya represents N or C(?O), provided that when Xa is C, Ya represents N, and when Xa is N, Ya represents C(?O), the double line consisting of the solid line and the broken line represents a single bond or double bond, Aa represents benzene ring, pyridine ring, and the like, Da represents tetrazole ring, imidazole ring, and the like, Ea represents —(CR9aR10a)p-Ta-, and Ga represents benzene ring, pyridine ring, and the like, which has a P2X4 receptor antagonistic activity.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: January 23, 2018
    Assignees: NIPPON CHEMIPHAR CO., LTD, KYUSHU UNIVERSITY
    Inventors: Shogo Sakuma, Kunio Kobayashi, Masatoshi Ushioda, Daisuke Saito, Toshiyasu Imai, Kazuhide Inoue
  • Patent number: 9840497
    Abstract: The present invention relates to a compound represented by the following general formula (II), wherein, in the formula, R1a to R6a represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, and the like, Xa represents C or N, Ya represents N or C(?O), provided that when Xa is C, Ya represents N, and when Xa is N, Ya represents C(?O), the double line consisting of the solid line and the broken line represents a single bond or double bond, Aa represents benzene ring, pyridine ring, and the like, Da represents tetrazole ring, imidazole ring, and the like, Ea represents —(CR9aR10a)p-Ta-, and Ga represents benzene ring, pyridine ring, and the like, which has a P2X4 receptor antagonistic activity.
    Type: Grant
    Filed: July 11, 2014
    Date of Patent: December 12, 2017
    Assignees: NIPPON CHEMIPHAR CO., LTD, KYUSHU UNIVERSITY
    Inventors: Shogo Sakuma, Kunio Kobayashi, Masatoshi Ushioda, Daisuke Saito, Toshiyasu Imai, Kazuhide Inoue
  • Publication number: 20170081294
    Abstract: The present invention relates to a compound represented by the following general formula (I), which has a P2X4 receptor antagonistic activity (in the formula, R1, R2 and R3 represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, an alkoxy group having 1 to 8 carbon atoms, a halogen atom, and the like, X represents C or N, Y represents N or C(?O), provided that when X is C, Y represents N, and when X is N, Y represents C(?O), the double line consisting of the solid line and the broken line represents a single bond or double bond, n represents an integer of 0 to 6, Z represents O, S, or an atomic bond, and A represents benzene ring, pyridine ring, and the like).
    Type: Application
    Filed: July 11, 2014
    Publication date: March 23, 2017
    Applicants: NIPPON CHEMIPHAR CO., LTD., KYUSHU UNIVERSITY
    Inventors: Shogo SAKUMA, Kunio KOBAYASHI, Masatoshi USHIODA, Toshiyasu IMAI, Kazuhide INOUE
  • Publication number: 20170065608
    Abstract: A P2X4 receptor antagonist such as paroxetine, a diazepinedione derivative having the following formula (IX) is used as an agent for preventing or treating neuropathic pain associated with Guillain-Barré syndrome: wherein R1 is hydrogen, a C1-8 alkyl group, or the like; each of R2 and R3 is hydrogen, a C1-8 alkyl group, or the like; each of R4 and R5 is hydrogen or the like; and W is a five-membered or six-membered heterocyclic ring optionally having one or more substituents and comprising one to four nitrogen atoms as the members of the ring.
    Type: Application
    Filed: October 28, 2016
    Publication date: March 9, 2017
    Inventors: Toshiyasu IMAI, Toru KAWASAKI, Toru OGAWA, Kazuhide INOUE
  • Publication number: 20160280667
    Abstract: The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R1 and R2 represent hydrogen atom and the like, or R1 and R2 bind together to form a naphthalene ring and the like together with the benzene ring to which they bind, R3 and R4 represent hydrogen atom and the like, R5 represents hydrogen atom and the like, R6 and R7 represent hydrogen atom and the like, X represents C, CH or N, Y represents N, NH or C(?O), provided that when X is N, Y is not N or NH, and when X is C or CH, Y is not C(?O), Z represents oxygen atom or sulfur atom, A represents benzene ring and the like, B represents NHC(?O) and the like, D represents an atomic bond and the like, E represents an atomic bond and the like, G represents benzene which may be substituted and the like, and m represents an integer of 0 to 5) or a pharmacologically acceptable salt thereof and a P2X4 receptor antagonist.
    Type: Application
    Filed: June 8, 2016
    Publication date: September 29, 2016
    Applicant: NIPPON CHEMIPHAR CO., LTD
    Inventors: Masatoshi USHIODA, Kunio KOBAYASHI, Daisuke SAITO, Shogo SAKUMA, Toshiyasu IMAI, Kazuhide INOUE
  • Publication number: 20160244434
    Abstract: The present invention relates to a compound represented by the following general formula (II), wherein, in the formula, R1a to R6a represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, and the like, Xa represents C or N, Ya represents N or C(?O), provided that when Xa is C, Ya represents N, and when Xa is N, Ya represents C(?O), the double line consisting of the solid line and the broken line represents a single bond or double bond, Aa represents benzene ring, pyridine ring, and the like, Da represents tetrazole ring, imidazole ring, and the like, Ea represents —(CR9aR10a)p-Ta-, and Ga represents benzene ring, pyridine ring, and the like, which has a P2X4 receptor antagonistic activity.
    Type: Application
    Filed: July 11, 2014
    Publication date: August 25, 2016
    Applicants: NIPPON CHEMIPHAR CO., LTD., KYUSHU UNIVERSITY
    Inventors: Shogo SAKUMA, Kunio KOBAYASHI, Masatoshi USHIODA, Daisuke SAITO, Toshiyasu IMAI, Kazuhide INOUE
  • Patent number: 9382236
    Abstract: The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R1 and R2 represent hydrogen atom and the like, or R1 and R2 bind together to form a naphthalene ring and the like together with the benzene ring to which they bind, R3 and R4 represent hydrogen atom and the like, R5 represents hydrogen atom and the like, R6 and R7 represent hydrogen atom and the like, X represents C, CH or N, Y represents N, NH or C(?O), provided that when X is N, Y is not N or NH, and when X is C or CH, Y is not C(?O), Z represents oxygen atom or sulfur atom, A represents benzene ring and the like, B represents NHC(?O) and the like, D represents an atomic bond and the like, E represents an atomic bond and the like, G represents benzene which may be substituted and the like, and m represents an integer of 0 to 5) or a pharmacologically acceptable salt thereof, and a P2X4 receptor antagonist.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: July 5, 2016
    Assignee: NIPPON CHEMIPHAR CO., LTD
    Inventors: Masatoshi Ushioda, Kunio Kobayashi, Daisuke Saito, Shogo Sakuma, Toshiyasu Imai, Kazuhide Inoue
  • Patent number: 8962613
    Abstract: A diazepine derivative having the following formula (III) or a pharmacologically acceptable salt thereof is used as A P2X4 receptor antagonist: wherein each of R21 and R22 is hydrogen, a C1-8 alkyl group or the like; R23 is hydrogen, a C1-8 alkyl group or the like; each of R24 and R25 is hydrogen, a C1-8 alkyl group or the like; R26 is hydrogen, a C1-8 alkyl group, a halogen atom, hydroxyl, nitro, cyano, phenyl optionally having one or more substituents, or a heterocyclic group optionally having one or more substituents or the like; and p is 0 or 1.
    Type: Grant
    Filed: July 13, 2011
    Date of Patent: February 24, 2015
    Assignee: Nippon Chemiphar Co., Ltd.
    Inventors: Shogo Sakuma, Masahiko Arai, Kunio Kobayashi, Yoshikazu Watanabe, Toshiyasu Imai, Kazuhide Inoue
  • Publication number: 20140357858
    Abstract: The present invention relates to a diazepine derivative represented by the following general formula (I) (in the formula, R1 and R2 represent hydrogen atom and the like, or R1 and R2 bind together to form a naphthalene ring and the like together with the benzene ring to which they bind, R3 and R4 represent hydrogen atom and the like, R5 represents hydrogen atom and the like, R6 and R7 represent hydrogen atom and the like, X represents C, CH or N, Y represents N, NH or C(?O), provided that when X is N, Y is not N or NH, and when X is C or CH, Y is not C(?O), Z represents oxygen atom or sulfur atom, A represents benzene ring and the like, B represents NHC(?O) and the like, D represents an atomic bond and the like, E represents an atomic bond and the like, G represents benzene which may be substituted and the like, and m represents an integer of 0 to 5) or a pharmacologically acceptable salt thereof, and a P2X4 receptor antagonist.
    Type: Application
    Filed: January 10, 2013
    Publication date: December 4, 2014
    Inventors: Masatoshi Ushioda, Kunio Kobayashi, Daisuke Saito, Shogo Sakuma, Toshiyasu Imai, Kazuhide Inoue