Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.2 is hydrogen or an aliphatic hydrocarbon residue which may be substituted with halogen, carboxy or esterified carboxy,R.sup.5 is carboxy or functionally modified carboxy and R.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, their preparation and their pharmaceutical uses.

Abstract: This invention relates particularly to a syn compound of the formula: ##STR1## wherein R.sup.2 is hydrogen or an aliphatic hydrocarbon residue which may be substituted with halogen, carboxy or esterified carboxy, R.sup.3 and R.sup.4 are each lower alkyl, R.sup.5 is carboxy or functionally modified carboxy and R.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, to pharmaceutical compositions containing the same and method of using the same for treating infectious disease.

Abstract: The invention relates particularly to syn compounds of the formula ##STR1## wherein R.sup.2 is C.sub.1 -C.sub.8 alkyl, R.sup.5 is carboxy or pharmaceutically acceptable esterified carboxy and R.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.

Abstract: 7-Substituted 3-cephem or cephem compounds characterized by the grouping, in the 7-position thereof, of the formula:R'--A--CONH--where R' is thiadiazolyl or amino thiazolyl, and a is methylene carrying oxyiimino, or R' is haloacetyl and A may also be methylene, their preparation, and pharmaceutical uses.

Abstract: The invention relates to new cephem compounds, of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl,R.sup.3 is halogen or lower alkoxy, andR.sup.4 is carboxy or protected carboxy,and a pharmaceutically acceptable salt thereof.

Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.2 is an aliphatic hydrocarbon residue substituted with halogen, carboxy or esterified carboxy,R.sup.4 is halogen or a group of the formula:--O--R.sup.7, in which R.sup.7 is lower alkyl,R.sup.5 is carboxy or functionally modified carboxy andR.sup.6 is amino or protected amino, and pharmaceutically acceptable salt thereof, processes for making the compounds, pharmaceutical compositions containing them and their use to treat infectious diseases.

Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.1 is thiadiazolyl,R.sup.2 is hydrogen or an aliphatic hydrocarbon residue which may be substituted with halogen, carboxy or esterified carboxy andR.sup.5 is carboxy or functionally modified carboxy, and pharmaceutically acceptable salt thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.

Abstract: A compound of the formula: ##STR1## wherein R.sup.2 is hydrogen or lower alkyl, R.sup.3 is carboxy or a protected carboxy group, X is --S-- or ##STR2## and the dotted line bridging the 2- to 4-positions of the formula indicates that the compound may be the 2- or 3-cephem derivative, and pharmaceutically acceptable salts thereof.

Abstract: The invention relates particularly to syn compounds of the formula: ##STR1## wherein R.sup.2 is hydrogen or an aliphatic hydrocarbon which may be substituted with halogen, carboxy or pharmaceutically acceptable esterified carboxy,R.sup.5 is carboxy or pharmaceutically acceptable esterified carboxy,R.sup.6 is amino or protected amino andR.sup.7 is lower alkanesulfonyl or arenesulfonyl and pharmaceutically acceptable salt thereof, processes for making them, pharmaceutical compositions containing them and their use in treating infectious diseases.

Abstract: This invention relates to novel cephem compounds of high antimicrobial activity, to processes for preparation of said compounds, and to pharmaceutical compositions containing said compounds, the cephem compounds being of the formula ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.2 is lower alkyl of from one to six carbon atoms substituted with aryl hydrocarbon of from 6 to 10 carbon atoms or substituted aryl hydrocarbon with at least one halogen, hydroxy, amino (lower) alkyl, amido (lower) alkyl, or lower alkyl substituent,R.sup.3 is carboxy or protected carboxy, andR.sup.4 is hydrogen,and its pharmaceutically acceptable salt.

Abstract: This invention relates to novel cepham compounds of antimicrobial activity, useful as intermediates in the preparation of antibiotics, said novel cepham compounds being of the formula: ##STR1## wherein R.sup.1 is phenyl (lower) alkanoylamino, phenoxy (lower) alkanoylamino or aminothiazolyl (lower) alkanoylamino substituted with a lower alkoxyimino group,R.sup.2 is carboxy or a protected carboxy group,R.sup.3 is formyl, hydroxymethyl or acyloxymethylene, andX is --S-- or --SO--, and its salt.

Abstract: A new process for preparing 3-methylenecepham compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group, andR.sup.2 is a carboxy or a protected carboxy group,or a salt thereof,which comprises reducing a compound of the formula: ##STR2## wherein R.sup.1 and R.sup.2 are each as defined above, andR.sup.3 is halogen or heterocyclicthio which may have suitable sutstituent, or a salt thereof, with a combination of a metal selected from the group consisting of zinc, tin and iron, and an ammonium salt of an acid selected from the group consisting of ammonium halide, ammonium carbonate and ammonium acetate, said 3-methylenecepham compounds being useful as intermediates for preparing antimicrobially active 3-cephem compounds.

Abstract: 3,7-disubstituted-3-cephem-4-carboxylic acid compounds having bacteriostatic properties and the following formula: ##STR1## in which R.sup.1 is thiadiazolyl or isothiazolyl, each of which may have suitable substituent(s), or thiazolyl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is carboxy or protected carboxy; R.sup.4 is hydrogen, acyloxy or a heterocyclicthio group which may have suitable substituent(s); and R.sup.5 is hydrogen or lower alkoxy, process for making same and treating infectious diseases therewith.

Abstract: In a continuous bulk polymerization process of a styrene type copolymer which is a copolymer consisting of 60 to 95% by weight of an aromatic vinyl monomer and 40 to 5% by weight of maleic anhydride, a continuous bulk polymerization process of a styrene type copolymer characterized in that at the first stage, continuous bulk polymerization is carried out using a vertical agitation system polymerization apparatus to a conversion of 30 to 60% by continuously feeding a mixed monomer of the aromatic vinyl monomer and maleic anhydride having a feed composition ratio corresponding to the copolymer, and at the second stage, and at the third stage, if necessary, continuous bulk polymerization is carried out to a conversion of 60 to 95% using a horizontal apparatus for processing highly viscous substances, equipped with one or two rotary shafts having agitation blade frames or agitation blades impaled thereon, by continuously and dividedly feeding maleic anhydride from plural feed ports disposed on said apparatus for

Abstract: The invention relates to new thiadiazolyl or thiazolyl-substituted cephem and cepham compounds, the pharmaceutically acceptable salts and bioprecursors thereof, of antimicrobial activity, processes for preparation thereof, intermediates for preparing the new compounds and to pharmaceutical compositions comprising the new compounds, and methods of using the compositions for treatment of infectious diseases.

Abstract: Novel 3-phosphonocephalosporanic acid derivatives and pharmaceutically acceptable salts thereof, which have antimicrobial activities; processes for the preparation thereof; pharmaceutical compositions comprising the same; and a method of using the same therapeutically for the treatment of infectious diseases in human beings or animals are disclosed.

Abstract: This invention relates to new cephem compounds. More particularly, it relates to new 7-substituted-3-cephem-4-carboxylic acid, its pharmaceutically acceptable salt and pharmaceutically acceptable bioprecursor thereof, which have antimicrobial activities, and processes for preparation thereof, to intermediate for preparing the same and processes for preparation thereof, and to pharmaceutical composition comprising the same and methods of using the same prophylactically and therapeutically for treatment of infectious diseases in human beings and animals.The cephem compounds of this invention include the compound represented by the formula (I): ##STR1## wherein R.sup.1 is amino or protected amino,R.sup.

Abstract: 3,7-Disubstituted-3-cephem-4-carboxylic acid compounds having bacteriostatic properties and the following formula: ##STR1## in which R.sup.1 is thiadiazolyl or isothiazolyl, each of which may have suitable substituent(s), or thiazolyl; R.sup.2 is hydrogen or lower alkyl; R.sup.3 is carboxy or protected carboxy; R.sup.4 is hydrogen, acyloxy or a heterocyclicthio group which may have suitable substituent(s); and R.sup.5 is hydrogen or lower alkoxy, process for making same and treating infectious diseases therewith.