Patents by Inventor Toshiyuki Isoe

Toshiyuki Isoe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of macrophage colony stimulating factor receptor
    Patent number: 7598258
    Abstract: An objective of the present invention is to provide compounds which have inhibitory activity against autophosphorylation of macrophage colony-stimulating factor receptors. The compounds of the present invention are represented by formula (I) and salt and solvate thereof: wherein X represents CH or N; Z represents O or S; R1, R2, and R3 represent H, optionally substituted alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkyl, alkoxy, trifluoromethyl or the like; R9 and R10 represent H, alkyl or the like; and any one of R11 and R12 represents H with the other representing alkyl and R13 represents an optionally substituted carbocyclic or heterocyclic ring or the like, or R11 represents H and R12 and R13 combine together to form a bicyclic carbocyclic ring.
    Type: Grant
    Filed: May 1, 2003
    Date of Patent: October 6, 2009
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Kazuo Kubo, Hiroaki Ohno, Toshiyuki Isoe, Tuyoshi Nishitoba
  • Quinoline derivatives and quinazoline derivatives having azolyl group
    Patent number: 7211587
    Abstract: An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein X and Z represent CH or N; Y represents O or S; R1, R2, and R3 represent H, alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkoxy or the like; R9 and R10 represent H, alkyl or the like; and R11 represents optionally substituted azolyl.
    Type: Grant
    Filed: June 7, 2004
    Date of Patent: May 1, 2007
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Kazuo Kubo, Teruyuki Sakai, Rika Nagao, Yasunari Fujiwara, Toshiyuki Isoe, Kazumasa Hasegawa
  • Quinoline derivatives and quinazoline derivatives
    Publication number: 20070027318
    Abstract: An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.
    Type: Application
    Filed: September 26, 2006
    Publication date: February 1, 2007
    Applicant: KIRIN BEER KABUSHIKI KAISHA
    Inventors: Kazuo Kubo, Yasunari Fujiwara, Toshiyuki Isoe
  • Quinoline derivatives and quinazoline derivatives
    Patent number: 7169789
    Abstract: An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.
    Type: Grant
    Filed: May 10, 2004
    Date of Patent: January 30, 2007
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Kazuo Kubo, Yasunari Fujiwara, Toshiyuki Isoe
  • Quinoline derivatives and quinazoline derivatives inhibiting autophosphorylation of macrophage colony stimulating factor receptor
    Publication number: 20060235033
    Abstract: An objective of the present invention is to provide compounds which have inhibitory activity against autophosphorylation of macrophage colony-stimulating factor receptors. The compounds of the present invention are represented by formula (I) and salt and solvate thereof: wherein X represents CH or N; Z represents O or S; R1, R2, and R3 represent H, optionally substituted alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkyl, alkoxy, trifluoromethyl or the like; R9 and R10 represent H, alkyl or the like; and any one of R11 and R12 represents H with the other representing alkyl and R13 represents an optionally substituted carbocyclic or heterocyclic ring or the like, or R11 represents H and R12 and R13 combine together to form a bicyclic carbocyclic ring.
    Type: Application
    Filed: May 1, 2003
    Publication date: October 19, 2006
    Inventors: Kazuo Kubo, Hiroaki Ohno, Toshiyuki Isoe, Tsuyoshi Nishitoba
  • Quinoline derivatives and quinazoline derivatives having azolyl group
    Patent number: 6821987
    Abstract: An object of the present invention is to provide compounds having potent antitumor activity. The compounds according to the present invention are compounds represented by formula (I) or pharmaceutically acceptable salts or solvates thereof: wherein X and Z represent CH or N; Y represents O or S; R1, R2, and R3 represent H, alkoxy or the like; R4 represents H; R5, R6, R7, and R8 represent H, halogen, alkoxy or the like; R9 and R10 represent H, alkyl or the like; and R11 represents optionally substituted azolyl.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: November 23, 2004
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Kazuo Kubo, Teruyuki Sakai, Rika Nagao, Yasunari Fujiwara, Toshiyuki Isoe, Kazumasa Hasegawa
  • Quinoline derivatives and quinazoline derivatives having azolyl group
    Publication number: 20040229876
    Abstract: An object of the present invention is to provide compounds having potent antitumor activity.
    Type: Application
    Filed: June 7, 2004
    Publication date: November 18, 2004
    Applicant: KIRIN BEER KABUSHIKI KAISHA
    Inventors: Kazuo Kubo, Teruyuki Sakai, Rika Nagao, Yasunari Fujiwara, Toshiyuki Isoe, Kazumasa Hasegawa
  • Quinoline derivatives and quinazoline derivatives
    Publication number: 20040209905
    Abstract: An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis.
    Type: Application
    Filed: May 10, 2004
    Publication date: October 21, 2004
    Applicant: KIRIN BEER KABUSHIKI KAISHA
    Inventors: Kazuo Kubo, Yasunari Fujiwara, Toshiyuki Isoe
  • Quinoline derivatives and quinazoline derivatives
    Patent number: 6797823
    Abstract: An object of the present invention is to provide compounds which have antitumor activity and do not change cytomorphosis. Disclosed are compounds represented by formula (I) and a pharmaceutically acceptable salts and solvates thereof and pharmaceutical compositions comprising said compounds: wherein X and Z each independently represent CH or N; R1 to R3 represent H, substituted alkoxy, unsubstituted alkoxy or the like; R4 represents H; R5 to R8 represent H, halogen, alkyl, alkoxy, alkylthio, nitro, or amino, provided that R5 to R8 do not simultaneously represent H; R9 and R10 represent H, alkyl, or alkylcarbonyl; and R11 represents alkyl, alkenyl, alkynyl, or aralkyl.
    Type: Grant
    Filed: July 23, 2001
    Date of Patent: September 28, 2004
    Assignee: Kirin Beer Kabushiki Kaisha
    Inventors: Kazuo Kubo, Yasunari Fujiwara, Toshiyuki Isoe
  • Quinoline derivatives and quinazoline derivatives having azolyl group
    Publication number: 20030087907
    Abstract: An object of the present invention is to provide compounds having potent antitumor activity.
    Type: Application
    Filed: April 26, 2002
    Publication date: May 8, 2003
    Applicant: KIRIN BEER KABUSHIKI KAISHA
    Inventors: Kazuo Kubo, Teruyuki Sakai, Rika Nagao, Yasunari Fujiwara, Toshiyuki Isoe, Kazumasa Hasegawa