Patents by Inventor Toshiyuki Matsudo

Toshiyuki Matsudo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190381300
    Abstract: A method for producing a microneedle device having a coating on the microneedles comprises a step A of drying a precursor composition containing a biologically active substance and a first solvent to obtain -a freeze-dried composition, a step B of mixing the freeze-dried composition with a second solvent to obtain a coating composition, and a step C of applying the coating composition to the microneedles and drying the same, wherein the precursor composition further contains a thickener, or a thickener is added when the freeze-dried composition and the second solvent are mixed.
    Type: Application
    Filed: February 20, 2018
    Publication date: December 19, 2019
    Inventors: Toru KOBAYASHI, Toshiyuki MATSUDO, Shinpei NISHIMURA, Seiji TOKUMOTO, Tetsuji KUWAHARA
  • Publication number: 20190015652
    Abstract: A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.
    Type: Application
    Filed: September 18, 2018
    Publication date: January 17, 2019
    Inventors: Kazuya KOMINAMI, Shinpei NISHIMURA, Seiji TOKUMOTO, Makoto OGURA, Toshiyuki MATSUDO, Naoki YAMAMOTO
  • Publication number: 20160107189
    Abstract: The present invention provides a system for manufacturing a therapeutic microneedle configured to regulate an air environment within a coating chamber for manufacturing a therapeutic microneedle by coating a microneedle with a coating liquid containing a drug, the system for manufacturing a therapeutic microneedle comprising an air compressor, a humidity regulator configured to regulate humidity of air supplied from the air compressor, and an air filter configured to eliminate microorganisms from air to be supplied to the inside of the coating chamber.
    Type: Application
    Filed: May 29, 2014
    Publication date: April 21, 2016
    Inventors: Eiji HASHIMOTO, Toshiyuki MATSUDO, Shinpei NISHIMURA, Seiji TOKUMOTO
  • Publication number: 20150157840
    Abstract: A microneedle sheet according to an embodiment comprises a plurality of microneedles formed on a sheet substantially along a principal surface of the sheet. The sheet is bent to raise the microneedles from the principal surface, and the raised microneedles pierce a skin.
    Type: Application
    Filed: June 11, 2013
    Publication date: June 11, 2015
    Inventors: Kazuya Kominami, Shinpei Nishimura, Seiji Tokumoto, Makoto Ogura, Toshiyuki Matsudo, Naoki Yamamoto
  • Patent number: 8771781
    Abstract: The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device (22) with a plurality of microneedles (21) is mounted on a table (23), while a mask plate (25) with a plurality of apertures (24) is fixed to a frame member (26), and a coating solution (27) is drawn in the direction of arrow A on the mask plate (25) using a spatula (28) to fill the apertures (24) with the coating solution. The microneedles (21) are inserted in the apertures (24) before or after the filling of the apertures (24) with the coating solution (27) to coat the microneedles (21).
    Type: Grant
    Filed: October 18, 2007
    Date of Patent: July 8, 2014
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Tetsuji Kuwahara
  • Publication number: 20130323293
    Abstract: A GLP-1 analogue composition for a microneedle device, including a GLP-1 analogue and at least one kind of solvent selected from the group consisting of water, glycerin, propylene glycol, ethylene glycol, 1,3-butylene glycol, and polyethylene glycol.
    Type: Application
    Filed: February 23, 2012
    Publication date: December 5, 2013
    Inventors: Takuya Umemoto, Toshiyuki Matsudo, Seiji Tokumoto
  • Patent number: 8419708
    Abstract: It is intended to provide a transdermal drug administration apparatus having microneedles, which is capable of piercing the skin by a simple procedure in the transdermal administration of a biologically active substance (drug) and allows rapid absorption of the biologically active substance. The present apparatus comprises a microneedle device (50) comprising a microneedle substrate (53) having a plurality of microneedles (51) capable of piercing the skin, an absorbent (11) disposed thereon, the absorbent (11) comprising a material capable of absorbing a liquid, and a dissolving solution reservoir (18) disposed on the absorbent (11), the dissolving solution reservoir (18) containing a dissolving solution (16) for dissolving a drug and being capable of disrupting a diaphragm (20) provided the dissolving solution reservoir (18) and the absorbent (11) by pressing. A coating containing a dry drug is disposed on the microneedles (51) and/or the microneedle substrate (53).
    Type: Grant
    Filed: February 7, 2007
    Date of Patent: April 16, 2013
    Assignee: Hisamitsu Pharmaceuticals Co., Inc.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Tetsuji Kuwahara
  • Publication number: 20130072874
    Abstract: An array 1 provided with microprotrusions comprises a base 2 and tapered microprotrusions 3 each disposed on the base 2 and tapering down toward the tip from the bottom. Letting a distance from the tip to the bottom on an arbitrary side of each microprotrusion 3 as a and letting the length of a second line segment prepared by projecting a first line segment representing the distance a onto the base 2 as b, a relationship of 1.0<(a/b)?7.5 holds.
    Type: Application
    Filed: May 25, 2011
    Publication date: March 21, 2013
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Shuji Ishitsuka
  • Publication number: 20130041330
    Abstract: The present invention provides a micro-needle device that includes a substrate, a micro-needle provided on the substrate, and a physiologically active composition deposited on the micro-needle and/or the substrate. In the micro-needle device, the physiologically active composition contains: at least one polyhydric alcohol selected from glycerin, ethylene glycol, propylene glycol and 1,3-butylene glycol; and a physiologically active substance, and contains substantially no water.
    Type: Application
    Filed: February 24, 2011
    Publication date: February 14, 2013
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Toshiyuki Matsudo, Shinpei Nishimura, Seiji Tokumoto, Kumi Morimoto
  • Publication number: 20120283642
    Abstract: A microneedle device having a coating including a high molecular weight pharmaceutical compound substantially uniformly is provided. A microneedle device (1) includes a plurality of microneedles (3) on a microneedle substrate (2), which are capable of piercing the skin. A portion of or entire surface of the microneedles (3) and/or the microneedle substrate (2) has a coating including a coating carrier in a solid state. The coating carrier includes a high molecular weight pharmaceutical compound and polysaccharides compatible with the high molecular weight pharmaceutical compound. Herein, as the polysaccharide, for example, pullulan or hydroxypropylcellulose can be used.
    Type: Application
    Filed: April 30, 2012
    Publication date: November 8, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Toshiyuki MATSUDO, Tetsuji KUWAHARA, Seiji TOKUMOTO
  • Publication number: 20120004626
    Abstract: The present invention aims to allow high molecular weight active ingredients to be contained in a coating agent substantially uniformly. For this purpose, a microneedle device 1 includes a microneedle base 2, and microneedles 3 capable of piercing a skin and being disposed on the microneedle base 2, wherein at least a part of a surface of the microneedles 3 and/or the microneedle base 2 is coated with a coating agent containing a high molecular weight active ingredient and a water-soluble polymer, and the content of the water-soluble polymer in the coating agent is 0.1 to 30% by weight, and the ratio of the content of the water-soluble polymer to the content of the high molecular weight active ingredient in the coating agent is 5:1 to 1:100.
    Type: Application
    Filed: January 25, 2010
    Publication date: January 5, 2012
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Tetsuji Kuwahara, Seiji Tokumoto, Toshiyuki Matsudo
  • Publication number: 20110288485
    Abstract: Provided is a microneedle device having a microneedle base and microneedles capable of piercing the skin and being from 300 ?m to 500 ?m in height disposed on the base, where at least a part of the surface of the microneedles and/or the microneedle base is coated with a coating agent containing an active ingredient and a coating carrier, and a blending ratio of the active ingredient and the coating carrier is 10:0.1 to 1:10. Also provided are methods for administering active ingredients efficiently and simply through the skin using the microneedle device.
    Type: Application
    Filed: December 25, 2009
    Publication date: November 24, 2011
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Tetsuji Kuwahara, Shuji Ishitsuka
  • Publication number: 20100280457
    Abstract: The present invention provides a method of coating microneedles by which the microneedles mounted on a microneedle device are coated accurately and easily in a mass-producible manner. In this method, a microneedle device (22) with a plurality of microneedles (21) is mounted on a table (23), while a mask plate (25) with a plurality of apertures (24) is fixed to a frame member (26), and a coating solution (27) is drawn in the direction of arrow A on the mask plate (25) using a spatula (28) to fill the apertures (24) with the coating solution. The microneedles (21) are inserted in the apertures (24) before or after the filling of the apertures (24) with the coating solution (27) to coat the microneedles (21).
    Type: Application
    Filed: October 18, 2007
    Publication date: November 4, 2010
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Tetsuji Kuwahara
  • Publication number: 20100221314
    Abstract: A microneedle device having a coating including a high molecular weight pharmaceutical compound substantially uniformly is provided. A microneedle device (1) includes a plurality of microneedles (3) on a microneedle substrate (2), which are capable of piercing the skin. A portion of or entire surface of the microneedles (3) and/or the microneedle substrate (2) has a coating including a coating carrier in a solid state. The coating carrier includes a high molecular weight pharmaceutical compound and polysaccharides compatible with the high molecular weight pharmaceutical compound. Herein, as the polysaccharide, for example, pullulan or hydroxypropylcellulose can be used.
    Type: Application
    Filed: October 15, 2008
    Publication date: September 2, 2010
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Toshiyuki Matsudo, Tetsuji Kuwahara, Seiji Tokumoto
  • Publication number: 20100047327
    Abstract: It is intended to provide a low molecular weight adjuvant which can be administered safely without inducing skin irritation or the like by transdermal or transmucosal administration and is for enhancing immunogenicity of an antigen efficiently. It can be achieved by an immunostimulant adjuvant containing at least one substance selected from the group consisting of aliphatic alcohols, free fatty acids and fatty acid derivatives but does not contain a substance represented by the following formula. (In the formula, R3 and R4 may be combined to form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.
    Type: Application
    Filed: January 31, 2008
    Publication date: February 25, 2010
    Inventors: Tetsuji Kuwahara, Seiji Tokumoto, Toshiyuki Matsudo
  • Publication number: 20100030100
    Abstract: There is provided an inexpensive microneedle device for diagnosis of an allergy, enabling one to perform a clear skin test with simple operation for a short period of time in the diagnosis of allergies. The microneedle device (1) comprises: a microneedle substrate (2), microneedles (3) formed on the substrate at a density of 100 to 10000 needles per 1 cm2, being capable of piercing the skin 50 ?m to 500 ?m deep, and allergen-holding means (4) formed on the microneedles, holding at least one allergen. The microneedles (3) can be prepared by the use of a non-metallic synthetic or natural resin material.
    Type: Application
    Filed: February 5, 2008
    Publication date: February 4, 2010
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Tetsuji Kuwahara
  • Publication number: 20090099502
    Abstract: The present invention provides a microneedle device having a coating, which is effective even with a low molecular weight active compound and can sustain the effect of the drug for a long period of time, and a transdermal drug administration apparatus with microneedles. The microneedle device (5) has, on a microneedle substrate (8), a plurality of microneedles (6) that can pierce the skin, wherein the surface of the microneedles (6) and/or the microneedle substrate (8) is partly or entirely coated in fixed state with a coating carrier containing polyvinyl alcohol. The polyvinyl alcohol preferably has a hydrolysis degree of 94.5 mol % or more. Furthermore, the coating carrier can contain a drug.
    Type: Application
    Filed: April 6, 2007
    Publication date: April 16, 2009
    Applicant: HISAMITSU PHARMACEUTICAL CO., INC.
    Inventors: Seiji Tokumoto, Toshiyuki Matsudo, Tetsuji Kuwahara
  • Patent number: D610690
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: February 23, 2010
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Seiji Tokumoto, Tetsuji Kuwahara, Toshiyuki Matsudo
  • Patent number: D617463
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: June 8, 2010
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Seiji Tokumoto, Tetsuji Kuwahara, Toshiyuki Matsudo
  • Patent number: D634017
    Type: Grant
    Filed: February 23, 2010
    Date of Patent: March 8, 2011
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Seiji Tokumoto, Tetsuji Kuwahara, Toshiyuki Matsudo