Abstract: A tool transfer system configured to transfer a tool between first and second tool holding devices by causing the first and second tool holding devices to be moved relative to each other. The first tool holding device includes a clamp sleeve forced in a direction toward the second tool holding device so as to be positioned in a clamping position. The second tool holding device includes: a hole defining member defining a receiving hole that is to receive the tool; and a movable engaging member that is movable between a working position and a non-working position depending on movement of the hole defining member. The movable engaging member is engageable with the clamp sleeve, while being positioned in the working position, such that the clamp sleeve can be moved, by engagement of the movable engaging member with the clamp sleeve, so as to be positioned in an unclamping position, during relative axial movement of the first and second tool holding devices toward each other.

Abstract: A tap with drill includes a drill portion including a plurality of chip discharge grooves and having drill blades for cutting a prepared hole. The tap further includes a tap portion for cutting the internal thread on an inner circumferential surface of the prepared hole formed by the drill blades, and oil holes. The tap with drill is applied for performing cutting work. The drill blades and thread cutting edges include three blades formed along chip discharge grooves, respectively. The oil holes are helically formed in three with the same leads as the chip discharge grooves and opened at relief surfaces of the drill blades, respectively. The chip discharge grooves straddle the drill portion and the tap portion in fixed groove sectional shapes and have negative lands swelled into grooves.

Abstract: A tool transfer system configured to transfer a tool between first and second tool holding devices by causing the first and second tool holding devices to be moved relative to each other. The first tool holding device includes a clamp sleeve forced in a direction toward the second tool holding device so as to be positioned in a clamping position. The second tool holding device includes: a hole defining member defining a receiving hole that is to receive the tool; and a movable engaging member that is movable between a working position and a non-working position depending on movement of the hole defining member. The movable engaging member is engageable with the clamp sleeve, while being positioned in the working position, such that the clamp sleeve can be moved, by engagement of the movable engaging member with the clamp sleeve, so as to be positioned in an unclamping position, during relative axial movement of the first and second tool holding devices toward each other.

Abstract: Carbapenem derivatives of formula (I): ##STR1## wherein (a) R.sub.1 is a hydrogen atom, an alkyl group of from 1 to 6 carbon atoms, a hydroxy-lower alkyl group or a protected hydroxy-lower alkyl group of from 1 to 6 carbon atoms in its alkyl moiety, (b) COOR.sub.2 is a carboxyl group, a carboxylate anion or a protected carboxyl group, (c) R.sub.3 is an alkyl group of from 1 to 6 carbon atoms and (d) R.sub.4 is a substituted or unsubstituted heterobicyclic group of formula (II): ##STR2## in which the partial structure ##STR3## is a 5- or 6-membered, saturated or unsaturated, nitrogen-containing heterocycle containing 1 to 4 hereto atoms each selected from the group consisting of oxygen, sulfur and nitrogen, at least one hetero atom being nitrogen, and is which R.sub.5 and R.sub.6 each is a hydrogen atom or an appropriate substituent, any isomeric form thereof, and pharmacologically acceptable salts thereof are potent and stable antimicrobial agents.

Abstract: Carbapenem derivatives which may be utilized as antibiotics and which show strong antibacterial activity against various bacterial strains including Pseudomonas aeruginosa. The compounds containing the derivatives are quite safe and are also stable against hydrolases such as dehyropeptidase (DHP).

Abstract: New derivatives of penem and pharmacutically acceptable salt thereof are herein disclosed; these compounds being useful as an antibacterial agent which has an extremely wide antibacterial spectrum, exhibits a high sensitivity to bacteria resistant to conventional penicillins and cephalosporin antibiotics and is excellent in its physico-chemical stability, solubility to water and biological stability, in particular, stability to decomposition by enzyme such as dehydropeptidase I in kidney, .beta.-lactamase; these derivatives of penem being able to be prepared by reacting 2-substituted sulfinyl derivative of penem with a thiol compound and then optionally removing protective group(s) and further alkylating the reaction product or vice versa.

Abstract: New derivatives of penem and pharmaceutically acceptable salt thereof are herein disclosed; these compounds being useful as an antibacterial agent which has an extremely wide antibacterial spectrum, exhibits a high sensitivity to bacteria resistant to conventional penicillins and cephalosporing antibiotics and is excellent in its physico-chemical stability, solubility to water and biological stability, in particular, stability to decomposition by enzyme such as dehydropeptidase I in kidney, .beta.-lactamase; these derivatives of penem being able to be prepared by reacting 2-substituted sulfinyl derivative of penem with a thiol compound and then optionally removing protective group(s) and further alkylating the reaction product or vice versa.