Patents by Inventor Tracey J. Brown

Tracey J. Brown has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20150265648
    Abstract: This application provides methods and compositions for the treatment of cancer. The application provides compositions comprising hyaluronic acid and a chemotherapeutic agent such as irinotecan that are useful in the treatment of cancer.
    Type: Application
    Filed: February 27, 2015
    Publication date: September 24, 2015
    Inventor: Tracey J. BROWN
  • Patent number: 9066919
    Abstract: This application provides methods and compositions for the treatment of cancer. The application provides compositions including hyaluronic acid and a chemotherapeutic agent such as irinotecan that are useful in the treatment of cancer.
    Type: Grant
    Filed: August 5, 2005
    Date of Patent: June 30, 2015
    Assignee: Alchemia Oncology Pty Limited
    Inventor: Tracey J. Brown
  • Publication number: 20150045289
    Abstract: The present invention relates to the method of pre-preparing pharmaceutical compositions for therapeutic uses, particularly pre-preparing medications for treating patients (e.g., cancer patients and the like) by intravenous infusion.
    Type: Application
    Filed: July 14, 2014
    Publication date: February 12, 2015
    Inventors: MICHAEL L. WEST, Tracey J. BROWN
  • Patent number: 8937052
    Abstract: The present invention relates generally to the field of therapeutics and in particular, chemotherapy. Even more particularly, the present invention provides therapeutic strategies which reduce the toxicity or enhance the efficacy of chemotherapeutic agents. Compositions and methods of treatment and prophylaxis are also contemplated by the present invention.
    Type: Grant
    Filed: July 27, 2006
    Date of Patent: January 20, 2015
    Assignee: Alchemia Oncology Pty Limited
    Inventor: Tracey J. Brown
  • Publication number: 20140328828
    Abstract: The present invention relates generally to treatment and prophylactic protocols for cellular disease or disorders, such as diseases and disorders associated with abnormal cellular proliferation. More particularly, the present invention provides uses of compositions comprising therapeutic antibodies and hyaluronan in the treatment or prophylaxis of cellular diseases and disorders.
    Type: Application
    Filed: December 4, 2013
    Publication date: November 6, 2014
    Applicant: ALCHEMIA ONCOLOGY PTY LIMITED
    Inventors: Tracey J. BROWN, Gary R. BROWNLEE
  • Patent number: 8741970
    Abstract: The present invention relates to the enhancement of the efficacy of drugs, and more particularly, with overcoming the resistance of cells or organisms to drugs. In particular, the present invention provides a method for enhancing the effectiveness of a cytotoxic or anti-neoplastic agent, comprising the step of co-administering said agent with hyaluronan, wherein co-administration with hyaluronan enhances the agent's cancer cell-killing potential.
    Type: Grant
    Filed: December 14, 2011
    Date of Patent: June 3, 2014
    Assignee: Alchemia Oncology Pty Limited
    Inventor: Tracey J. Brown
  • Patent number: 8623354
    Abstract: The present invention relates generally to treatment and prophylactic protocols for cellular diseases or disorders, such as diseases and disorders associated with abnormal cellular proliferation. More particularly, the present invention provides compositions comprising therapeutic antibodies and hyaluronan and their use in the treatment or prophylaxis of cellular diseases and disorders.
    Type: Grant
    Filed: September 4, 2006
    Date of Patent: January 7, 2014
    Assignee: Alchemia Oncology Pty Limited
    Inventors: Tracey J. Brown, Gary R. Brownlee
  • Publication number: 20130197103
    Abstract: The present invention relates to the enhancement of the efficacy of drugs, and more particularly, with overcoming the resistance of cells or organisms to drugs. In particular, the present invention provides a method for enhancing the effectiveness of a cytotoxic or anti-neoplastic agent, comprising the step of co-administering said agent with hyaluronan, wherein co-administration with hyaluronan enhances the agent's cancer cell-killing potential.
    Type: Application
    Filed: December 14, 2011
    Publication date: August 1, 2013
    Applicant: Alchemia Oncology Pty Limited
    Inventor: Tracey J. BROWN
  • Patent number: 8460658
    Abstract: The present invention relates generally to the modulation of hyaluronan (HA) synthesis and degradation. The present invention further contemplates modulation of cellular proliferation, useful in the prophylaxis and/or treatment of inflammatory disorders including hyperproliferative conditions, such as but not limited to, cancer and psoriasis. The present invention is directed to compounds, agents, pharmaceutically active agents, medicaments, therapeutics, actives, drugs and the like which specifically target a portion of HAS which is accessible to the extracellular environment in malignant or inflammatory or proliferative cells but which portion is not accessible to the external environment in “normal” cells. A “normal” cell in this instance is a non-malignant, inflammatory or proliferative cell.
    Type: Grant
    Filed: June 13, 2011
    Date of Patent: June 11, 2013
    Assignee: Alchemia Oncology Pty Limited
    Inventors: Tracey J. Brown, Gary R. Brownlee
  • Patent number: 8388993
    Abstract: The present invention relates to the enhancement of bioavailability of chemotherapeutic agents for the treatment of disease. In particular, the present invention relates to a method of enhancing the bioavailability of a chemotherapeutic agent comprising the step of administering to a subject in need thereof a therapeutically effective amount of hyaluronan.
    Type: Grant
    Filed: May 1, 2006
    Date of Patent: March 5, 2013
    Assignee: Alchemia Oncology Pty Limited
    Inventor: Tracey J. Brown
  • Patent number: 8287894
    Abstract: This application provides methods and compositions for the treatment of cancer. The application provides compositions comprising hyaluronic acid and a chemotherapeutic agent such as irinotecan that are useful in the treatment of cancer.
    Type: Grant
    Filed: July 27, 2005
    Date of Patent: October 16, 2012
    Assignee: Alchemia Oncology Pty Limited
    Inventors: Tracey J. Brown, Richard M. Fox
  • Publication number: 20120009193
    Abstract: The present invention relates generally to the modulation of hyaluronan (HA) synthesis and degradation. More particularly, the present invention provides compositions and methods for modulating the expression of genetic material encoding HA synthase (HAS) and other enzymes or receptors primarily involved in hyaluronan metabolism; or modulating the proteins that synthesise or degrade hyaluronan including HAS function or activity. The compositions include or comprise nucleic acid molecules and interactive molecules such as antibodies and small molecule inhibitors and HAS substrate analogs. The present invention further contemplates modulation of cellular proliferation, useful in the prophylaxis and/or treatment of inflammatory disorders including hyperproliferative conditions, such as but not limited to, cancer and psoriasis.
    Type: Application
    Filed: June 13, 2011
    Publication date: January 12, 2012
    Applicant: Alchemia Oncology Pty Limited
    Inventors: Tracey J. Brown, Gary R. Brownlee
  • Patent number: 7985844
    Abstract: Modulation of Hyaluronan (HA) synthesis and degradation is disclosed by compounds and compositions that are capable of reducing the level of hyaluronan synthase (HAS) or hyaluronidase (HYAL) or the function or activity of HAS or HYAL. The compounds and compositions can also inhibit the expression of genetic material encoding these enzymes. The compounds and compositions comprise nucleic acid molecules and interactive molecules such as antibodies, small molecule inhibitors and substrate analogs of HAS and HYAL. The compounds and compositions are useful in the prophylaxis and/or treatment of inflammatory disorders including hyperproliferative conditions, such as but not limited to, cancer and psoriasis.
    Type: Grant
    Filed: December 15, 2009
    Date of Patent: July 26, 2011
    Assignee: Alchemia Oncology Pty Limited
    Inventors: Tracey J. Brown, Gary R. Brownlee
  • Patent number: 7662929
    Abstract: Modulation of Hyaluronan (HA) synthesis and degradation is disclosed by compounds and compositions that are capable of reducing the level of hyaluronan synthase (HAS) or hyaluronidase (HYAL) or the function or activity of HAS or HYAL. The compounds and compositions can also inhibit the expression of genetic material encoding these enzymes. The compounds and compositions comprise nucleic acid molecules and interactive molecules such as antibodies, small molecule inhibitors and substrate analogs of HAS and HYAL. The compounds and compositions are useful in the prophylaxis and/or treatment of inflammatory disorders including hyperproliferative conditions, such as but not limited to, cancer and psoriasis.
    Type: Grant
    Filed: October 11, 2004
    Date of Patent: February 16, 2010
    Assignee: Alchemia Oncology Pty Limited
    Inventors: Tracey J. Brown, Gary R. Brownlee
  • Publication number: 20090220497
    Abstract: The present invention relates generally to treatment and prophylactic protocols for cellular diseases or disorders, such as diseases and disorders associated with abnormal cellular proliferation. More particularly, the present invention provides compositions comprising therapeutic antibodies and hyaluronan and their use in the treatment or prophylaxis of cellular diseases and disorders.
    Type: Application
    Filed: September 4, 2006
    Publication date: September 3, 2009
    Inventors: Tracey J. Brown, Gary Brownlee
  • Publication number: 20090068183
    Abstract: The present invention is directed to compounds, agents, pharmaceutically active agents, medicaments, therapeutics, actives, drugs and the like which specifically target a portion of the HAS molecule which is accessible to the extracellular environment in a first form of a cell but which is not accessible to the extracellular environment in another form of or in a transformed cell form the same or related cell. In particular, the present invention provides compounds which target a portion of HAS which is accessible to the extracellular environment in malignant or inflammatory or proliferative cells but which portion is not accessible to the external environment in “normal” cells. A “normal” cell in this instance is a non-malignant, inflammatory or proliferative cell.
    Type: Application
    Filed: March 23, 2007
    Publication date: March 12, 2009
    Applicant: Alchemia Oncology Limited
    Inventors: Tracey J. Brown, Gary Brownlee
  • Publication number: 20090054537
    Abstract: The present invention relates generally to the field of therapeutics and in particular, chemotherapy. Even more particularly, the present invention provides therapeutic strategies which reduce the toxicity or enhance the efficacy of chemotherapeutic agents. Compositions and methods of treatment and prophylaxis are also contemplated by the present invention.
    Type: Application
    Filed: July 27, 2006
    Publication date: February 26, 2009
    Applicant: Alchemia Oncoloogy Pty Limited
    Inventor: Tracey J. Brown