Abstract: The present invention relates to compositions and methods using for activating Peroxisomal Proliferator Activating Receptor (PPAR)-?/? and/or PPAR-?. In some embodiments, the present invention relates to compounds and methods of treating a disease or disorder associated with PPAR-?/? and/or PPAR-?. In some embodiments, present invention relates to compounds and methods of treating Alzheimer's disease, diabetes, and reduced cognition.

Abstract: The improved saddle structure of the invention comprises first and second opposed side panels, a plurality of resilient transverse arched rib members connecting the first and second opposed side panels, and a spine member extending longitudinally between the first and second side panels. The spine member is connected to each rib member at a central crown portion of the rib member. The spine member can comprise one or more elongate members or a plurality of connecting members joining the rib members at their crown portions, and the spine member is of sufficient flexibility to flex with the flexure of the spine of an animal on which the saddle structure is fitted. A saddle seat is secured to the spine member and/or rib members. The saddle structure of the invention provides a saddle structure for use on the back of an animal whereby localised load pressure points are reduced while allowing flexure of the animal's spine, and whereby load is distributed more evenly along the length of the saddle structure.

Abstract: The improved saddle structure of the invention comprises first and second opposed side panels, a plurality of resilient transverse arched rib members connecting the first and second opposed side panels, and a spine member extending longitudinally between the first and second side panels. The spine member is connected to each rib member at a central crown portion of the rib member. The spine member can comprise one or more elongate members or a plurality of connecting members joining the rib members at their crown portions, and the spine member is of sufficient flexibility to flex with the flexure of the spine of an animal on which the saddle structure is fitted. A saddle seat is secured to the spine member and/or rib members. The saddle structure of the invention provides a saddle structure for use on the back of an animal whereby localised load pressure points are reduced while allowing flexure of the animal's spine, and whereby load is distributed more evenly along the length of the saddle structure.