Patents by Inventor Traci Mansfield

Traci Mansfield has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of Treating Ovarian and Renal Cancer Using Antibodies Against T Cell Immunoglobulin Domain and Mucin Domain 1 (TIM-1) Antigen
    Publication number: 20170267750
    Abstract: The invention described herein is related to antibodies directed to the antigen TIM-1 and uses of such antibodies for the treatment of cancer (e.g., renal and ovarian cancer). In particular, there are provided fully human monoclonal antibodies directed to the antigen TIM-1. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3, are provided. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies are also provided.
    Type: Application
    Filed: March 22, 2017
    Publication date: September 21, 2017
    Inventors: Kam Fai Tse, Vincent A. Pollack, John MacDougall, Suresh G. Shenoy, Traci Mansfield, Henri Lichenstein, Michael E. Jeffers, William J. LaRochelle
  • Compositions and methods for hepatoprotection and treatment of cholestasis
    Patent number: 6987121
    Abstract: Methods for the treatment of cholestatic liver disease and reduction and prevention of hepatic injury resulting from cholestasis via administration of a FXR ligand are provided.
    Type: Grant
    Filed: April 25, 2002
    Date of Patent: January 17, 2006
    Assignee: SmithKline Beecham Corporation
    Inventors: Steven Anthony Kliewer, Timothy Mark Willson, Traci Mansfield
  • Methods of using farnesoid x receptor (frx) agonists
    Publication number: 20050107475
    Abstract: Treatment of human hepatocytes with farnesoid X receptor (FXR) agonists resulted in increased expression of FGF-19. Methods of using FXR agonists to alter cell metabolism, and in pharmaceutical weight loss methods, are described.
    Type: Application
    Filed: March 19, 2003
    Publication date: May 19, 2005
    Inventors: Stacey Jones, Steven Kliewer, Traci Mansfield
  • Tumor marker and methods of use
    Publication number: 20050064402
    Abstract: The use of the protein kinase “PBK” (PDZ-binding kinase) as a tumor marker in various tissue types is discussed. Methods of detecting overexpression of the protein, and kits useful therefore, are described.
    Type: Application
    Filed: October 1, 2001
    Publication date: March 24, 2005
    Inventors: Susan Goldsworthy, David Jensen, Traci Mansfield
  • Protein-protein complexes and methods of using same
    Patent number: 6753314
    Abstract: The invention provides complexes of at least two polypeptides, and methods of using the same. Purified complexes of two polypeptides are provided, including chimeric complexes, and chimeric polypeptides and complexes thereof are also provided, as are nucleic acids encoding chimeric polypeptides and vectors and cells containing the same. Also provided are methods of identifying agents that disrupt polypeptide complexes, methods of identifying complex or polypeptide in a sample, and for removing the same, methods of determining altered expression of a polypeptide in a subject, and methods of treating/preventing disorders involving altered levels of complex or polypeptide.
    Type: Grant
    Filed: March 29, 2000
    Date of Patent: June 22, 2004
    Assignee: CuraGen Corporation
    Inventors: Loic Giot, Traci A. Mansfield