Abstract: The present disclosure provides therapeutic methods of treating a cancer patient with TGO2 and a second therapeutic agent, e.g., TGO2 and an immune checkpoint inhibitor, TGO2 and a COX-2 inhibitor, or TGO2 and an immune checkpoint inhibitor and a COX-2 inhibitor.

Abstract: Receiving information associated with a health care service provided to a patient; distributing a plurality of rules for determining responsibility for payment for the health care service across a plurality of hierarchical computer-implemented auditing systems including a primary auditing system and a secondary auditing system; generating, using the primary auditing system, a first payment recommendation for the health care service based on a first subset of the plurality of rules and the information associated with the health care service; communicating the information associated with the health care service to the secondary auditing system; generating, using the secondary auditing system, a second payment recommendation for the health care service based on a second subset of the plurality of rules and the information associated with the health care service; and merging the first payment recommendation with the second payment recommendation to generate a final payment recommendation for the health care servi

Abstract: A method includes receiving information associated with a health care service provided to a patient; distributing a plurality of rules for determining responsibility for payment for the health care service across a plurality of hierarchical auditing systems including a primary auditing system and a secondary auditing system; generating, using the primary auditing system, a first payment recommendation for the health care service based on a first subset of the plurality of rules and the information associated with the health care service; communicating the information associated with the health care service to the secondary auditing system; generating, using the secondary auditing system, a second payment recommendation for the health care service based on a second subset of the plurality of rules and the information associated with the health care service; and merging the first payment recommendation with the second payment recommendation to generate a final payment recommendation for the health care service.

Abstract: A method to verify the validity of an address to be used in the generation of an indicium by an IBIP open metering system includes entering an address into the metering system; verifying that an address record corresponding to the address exists in an address record database for the metering system; determining from information stored in the address record that the address record is valid; and generating indicium using at least some of said information form the address record and printing said indicium. In determining the freshness of the address record, the method verifies that a postal code exists, that the last cleansing of the address record was later than the last modification of the address record; the validity of a validation field in the address record; and that the time of the last cleansing of the address record is fresh.

Abstract: The subject invention relates to the generation, transmission, reception and/or use electronically, of parcel manifest and inquiry data over a carrier management or shipping system that utilizes electronic data interchange or EDI. This generation, transmission, reception and/or use of EDI will replace or reduce the current methods of using paper manifests and manual phone inquiries associated with carrier management and shipping systems.