Patents by Inventor Trai-Ming Yeh

Trai-Ming Yeh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Composition of subunit dengue vaccine
    Patent number: 11786587
    Abstract: The present invention relates to a composition of subunit dengue vaccine comprising a fusion protein of conjugating or connecting delta C nonstructural protein 1 (NS1?C or truncated NS1?C) to at least one polypeptides of NS3c (or truncated NS3c) and/or consensus envelope protein domain III (cEDIII), thereby enhancing better protection against DENV challenge and alleviating associated pathological effects.
    Type: Grant
    Filed: June 19, 2020
    Date of Patent: October 17, 2023
    Assignee: NATIONAL CHENG KUNG UNIVERSITY
    Inventors: Yee-Shin Lin, Trai-Ming Yeh, Yung-Chun Chuang, Chia-Yi Yu, Hsin-Wei Chen, Shu-Wen Wan, Shu-Ying Wang, Tzong-Shiann Ho, Dar-Bin Shieh
  • Anti-dengue virus antibody, pharmaceutical composition comprising the same, and uses thereof
    Patent number: 11142567
    Abstract: Disclosed herein is an anti-DENV antibody, a pharmaceutical composition comprising the same, and uses thereof. According to embodiments of the present disclosure, the anti-DENV antibody comprises a heavy chain variable region and a light chain variable region, in which the heavy chain variable region comprises amino acid sequences of SEQ ID NOs: 1-3, and the light chain variable region comprises amino acid sequences of SEQ ID NOs: 5-7.
    Type: Grant
    Filed: May 22, 2018
    Date of Patent: October 12, 2021
    Assignees: NATIONAL CHENG KUNG UNIVERSITY, DCB-USA LLC
    Inventors: Trai-Ming Yeh, Yung-Chun Chuang, Yen-Chung Lai
  • COMPOSITION OF SUBUNIT DENGUE VACCINE
    Publication number: 20200397884
    Abstract: The present invention relates to a composition of subunit dengue vaccine comprising a fusion protein of conjugating or connecting delta C nonstructural protein 1 (NS1?C or truncated NS1?C) to at least one polypeptides of NS3c (or truncated NS3c) and/or consensus envelope protein domain III (cEDIII), thereby enhancing better protection against DENV challenge and alleviating associated pathological effects.
    Type: Application
    Filed: June 19, 2020
    Publication date: December 24, 2020
    Inventors: Yee-Shin Lin, Trai-Ming Yeh, Yung-Chun Chuang, Chia-Yi Yu, Hsin-Wei Chen, Shu-Wen Wan, Shu-Ying Wang, Tzong-Shiann Ho, Dar-Bin Shieh
  • ANTI-DENGUE VIRUS ANTIBODY, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AND USES THEREOF
    Publication number: 20200087383
    Abstract: Disclosed herein is an anti-DENV antibody, a pharmaceutical composition comprising the same, and uses thereof. According to embodiments of the present disclosure, the anti-DENV antibody comprises a heavy chain variable region and a light chain variable region, in which the heavy chain variable region comprises amino acid sequences of SEQ ID NOs: 1-3, and the light chain variable region comprises amino acid sequences of SEQ ID NOs: 5-7.
    Type: Application
    Filed: May 22, 2018
    Publication date: March 19, 2020
    Applicants: NATIONAL CHENG KUNG UNIVERSITY, DCB-USA LLC
    Inventors: Trai-Ming YEH, Yung-Chun CHUANG, Yen-Chung LAI
  • Plasminogen-activating antibody, use and producing method thereof and agent including the same
    Patent number: 8784820
    Abstract: An antibody for activating plasminogen is provided. The antibody is produced from a hybridoma cell line deposited on Nov. 24, 2011 under accession number BCRC 960433 at Food Industry Research and Development Institute, 331 Shih-Pin Road, Hsinchu 300, Taiwan. The uses and producing method of the antibody, and an agent including the antibody used for treating stroke, myocardial infarction or syndromes cause by thrombus are also disclosed.
    Type: Grant
    Filed: November 2, 2012
    Date of Patent: July 22, 2014
    Inventors: Trai-Ming Yeh, Yung-Chun Chuang