Patents by Inventor Travis Besanger

Travis Besanger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SYNTHESIS AND USE OF RADIOLABELLED INSULIN ANALOGUES
    Publication number: 20120100071
    Abstract: A radiolabelled insulin analogue is provided. The analogue comprises a radiolabel linked to an insulin analogue at an amino acid at the terminal end of the B chain of the insulin analogue.
    Type: Application
    Filed: June 7, 2010
    Publication date: April 26, 2012
    Inventors: John Valliant, Chitra Sundararajan, Katharina Guenther, Travis Besanger
  • METHOD OF IMMOBILIZING MEMBRANE-ASSOCIATED MOLECULES
    Publication number: 20080261825
    Abstract: The present invention relates to methods of immobilizing membrane-associated molecules within a sol-gel matrix. The membrane-associated molecule is embedded in the bilayer of a liposome. The molecule-liposome assembly remains functionally intact when it is immobilized within a protein and membrane-compatible sol-gel derived from polyol silane precursors or sodium silicate. The activity and stability of the entrapped membrane-associated molecule was significantly improved in macroporous silica.
    Type: Application
    Filed: June 27, 2008
    Publication date: October 23, 2008
    Inventors: John D. Brennan, Michael A. Brook, Travis Besanger
  • Methods for substrate and modulator screening using enzyme-reactor chromatography/tandem mass spectrometry
    Publication number: 20060226082
    Abstract: The present invention relates to a method of screening compounds for modulation and binding to proteins, in particular proteins that have been immobilized in a monolithic chromatographic stationary phase. The method involves observing the conversion of a substrate to product by the protein and determining a product to substrate ratio. Changes in this ratio in the presence of another compound indicates that the other compound is a modulator of the enzyme. Various applications of this method to compound screening, including high throughput screening formats, are described.
    Type: Application
    Filed: March 15, 2006
    Publication date: October 12, 2006
    Applicant: McMaster University
    Inventors: Michael Brook, John Brennan, Richard Hodgson, Travis Besanger
  • Method of immobilizing membrane-associated molecules
    Publication number: 20050032246
    Abstract: The present invention relates to methods of immobilizing membrane-associated molecules within a sol-gel matrix. The membrane-associated molecule is embedded in the bilayer of a liposome. The molecule-liposome assembly remains functionally intact when it is immobilized within a protein and membrane-compatible sol-gel derived from polyol silane precursors or sodium silicate. The activity and stability of the entrapped membrane-associated molecule was significantly improved in macroporous silica.
    Type: Application
    Filed: April 2, 2004
    Publication date: February 10, 2005
    Applicant: McMaster University
    Inventors: John Brennan, Michael Brook, Travis Besanger
  • Method of immobilizing membrane-associated molecules
    Publication number: 20040166592
    Abstract: The present invention relates to methods of immobilizing membrane-associated molecules within a sol-gel matrix. The membrane-associated molecule is embedded in the bilayer of a liposome. The molecule-liposome assembly remains functionally intact when it is immobilized within a protein and membrane-compatible sol-gel derived from polyol silane precursors or sodium silicate.
    Type: Application
    Filed: November 14, 2003
    Publication date: August 26, 2004
    Applicant: McMaster University
    Inventors: John D. Brennan, Michael A. Brook, Travis Besanger