Abstract: Systems and methods for treatment planning are provided. In some embodiments, a method includes: receiving a plurality of digital representations of a plurality of intermediate tooth arrangements configured to adjust a patient's teeth from an initial tooth arrangement toward a target tooth arrangement, where the target tooth arrangement comprises a change in mass of at least one tooth relative to the initial tooth arrangement; outputting a first heatmap showing a difference in tooth mass between a first intermediate tooth arrangement and the target tooth arrangement; outputting a second heatmap showing a difference in tooth mass between a second intermediate tooth arrangement and the target tooth arrangement; and receiving a user input selecting the first intermediate tooth arrangement or the second intermediate tooth arrangement for use in a treatment plan based on a comparison between the first heatmap and the second heatmap.

Abstract: Systems and methods for planning a treatment for a patient's teeth are provided. In some embodiments, a method includes receiving input data representing an initial tooth arrangement of a patient's teeth. The method can include determining a target tooth arrangement for the patient's teeth, the target tooth arrangement including a change in mass of at least one tooth. The method can also include generating a plurality of intermediate tooth arrangements configured to adjust the patient's teeth from the initial tooth arrangement toward the target tooth arrangement. The method can further include generating instructions to output a visualization showing a difference in tooth mass between at least one intermediate tooth arrangement of the plurality of intermediate tooth arrangements and the target tooth arrangement.

Abstract: Systems and methods for planning a treatment for a patient's teeth are provided. In some embodiments, a method includes receiving a treatment plan including a target tooth arrangement including a change in mass of at least one tooth. The method can also include outputting a graphical user interface including a visualization of the treatment plan. The visualization can include a plurality of digital models, each digital model representing an intermediate tooth arrangement configured to adjust the patient's teeth toward the target tooth arrangement. The visualization can also include a heatmap overlaid onto at least one digital model of the plurality of digital models. The heatmap can show a difference in tooth mass between the target tooth arrangement and the corresponding at least one intermediate tooth arrangement of the at least one digital model.

Abstract: Systems and methods for planning a treatment for a patient’s teeth are provided. In some embodiments, a method includes receiving input data representing an initial tooth arrangement of a patient’s teeth. The method can include determining a target tooth arrangement for the patient’s teeth, the target tooth arrangement including a change in mass of at least one tooth. The method can also include generating a plurality of intermediate tooth arrangements configured to adjust the patient’s teeth from the initial tooth arrangement toward the target tooth arrangement. The method can further include generating instructions to output a visualization showing a difference in tooth mass between at least one intermediate tooth arrangement of the plurality of intermediate tooth arrangements and the target tooth arrangement.

Abstract: Materials, systems and methods are provided for qualitative assessment of exposure of a person to ionizing radiation by measuring amounts of the biomarkers, wherein a change compared with corresponding un-irradiated control reference ranges of the biomarkers, provides the assessment, wherein the biomarkers include (i) alpha-1-Antichymotrypsin (ACT), (ii) Fms-related tyrosine kinase 3 ligand (Flt3L), and (iii) one or more additional proteins.

Abstract: Materials, systems and methods are provided for qualitative assessment of exposure of a person to ionizing radiation by measuring amounts of the biomarkers, wherein a change compared with corresponding un-irradiated control reference ranges of the biomarkers, provides the assessment, wherein the biomarkers include (i) alpha-1-Antichymotrypsin (ACT), (ii) Fms-related tyrosine kinase 3 ligand (Flt3L), and (iii) one or more additional proteins.

Abstract: Materials, systems and methods are provided for qualitative assessment of exposure of a person to ionizing radiation by measuring amounts of the biomarkers, wherein a change compared with corresponding un-irradiated control reference ranges of the biomarkers, provides the assessment, wherein the biomarkers include (i) alpha-1-Antichymotrypsin (ACT), (ii) Fms-related tyrosine kinase 3 ligand (Flt3L), and (iii) one or more additional proteins.

Abstract: The present invention is directed to methods and pharmaceutical compositions for treating a mammal suffering from malaria or the sequelae of malarial infection, or for preventing a malarial infection, or for ameliorating the symptoms associated with a malarial infection using a therapeutically effective amount of an agent that down regulates G protein mediated functions. Also contemplated are methods for screening for novel compounds that down regulate G protein receptors, and the use of these compounds for treating mammals having malaria.