Abstract: Modifications to both hardware and enzymatic reactions used in single cell analyses such as but not limited to Seq-well that enable significant increases in the yield of transcripts per cell, portability and ease of use, increased scalability of the assay, and linkage of transcript information to other measurements made in the picowell arrays are disclosed.

Abstract: Techniques for predicting the immunosuppression status of an individual patient in a computing environment are disclosed. In one particular embodiment, the techniques may be realized as a method comprising receiving a set of medical records associated with a patient, extracting a set of immunosuppression features based on the set of medical records, estimating, a likelihood of immunosuppression of the patient based on the set of immunosuppression features, generating an immunosuppression output comprising one or more features among the set of immunosuppression features and an immunosuppression classification based on the likelihood of immunosuppression of the patient, and displaying the immunosuppression output through at least one interface.

Abstract: Methods and compositions for treating or preventing a disease by modulating a microenvironment of a cell or cell mass in a subject, the method comprising administrating an effective amount of one or more modulating agents that modulate mast cells, plasma cells, Th1-Th17 cells, and/or CD8+ T cells in the subject.

Abstract: The present invention relates to functionalized solid supports and methods of making functionalized solid supports. Methods for preparing a population of high quality functionalized solid supports for use in various nucleic acid analysis methods are provided. The invention also provides methods for validation and quality control of the functionalization steps.

Abstract: This disclosure describes improvements to both hardware and enzymatic reactions used in single cell analyses such as but not limited to Seq-well that enable significant increases in the yield of transcripts per cell, improved portability and ease of use, increased scalability of the assay, and linkage of transcript information to other measurements made in the picowell arrays.

Abstract: The present application provides a method of assembling a container for one or multiple parallel steps of biochemical analysis on one or more cells comprising performing molecular bonding of a porous membrane on an apical or basal surface of an array having a plurality of wells, wherein the molecular bonding substantially isolates each well from adjacent wells.

Abstract: Both a system and a method for converting two AGTAW welders into a AGMAW welder is provided. The system generally comprises a MIG weldhead for replacing the TIG weldhead of one of the AGTAW welders, a pulser multiplier circuit for increasing the frequency of the power supply output current from 10 to between 300 and 800 pulses per second, and a wire feed motor and motor control circuit capable of feeding weld wire at a rate compatible with a AGMAW welding operation. In the method of the invention, the control circuit assembly of one of the AGTAW welders is connected in parallel to the power supplies of both of the two AGTAW welders, and the outputs of these power supplies are likewise connected in parallel. The TIG weldhead of one of the AGTAW welders is replaced with the MIG weldhead, and the pulser multiplier circuit is selectively connected to the current pulser of the single control circuit assembly which controls both power supplies.