Abstract: Control methods for vapor compression systems and multiple-load vapor compression systems having one or more refrigeration loops include selecting a desired set-point temperature range for a load temperature at one or more load locations. The vapor compression system is then operated to transfer heat from the one or more load locations to a rejection location. While the vapor compression system is operating, a control apparatus continually adjusts various parameters. A capacity of an adjustable-capacity compressor is adjusted to maintain with respect to an evaporator load a maximum low-side pressure of the refrigeration loop as measured by a first sensor. An adjustable rejection capacity of a rejection apparatus is adjusted to maintain a minimum high-side pressure of the refrigeration loop as measured by a second sensor. An adjustable opening of an expansion valve is adjusted to maintain a load temperature measured by the third sensor within the desired set-point temperature range.