Patents by Inventor Travis Mickle

Travis Mickle has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stereoisomer Conjugates of Dextrorphan
    Publication number: 20260098013
    Abstract: The present technology provides a class of compounds which are amino acid ester conjugates of dextrorphan, wherein the amino acids are diestereomerically pure, which have improved bioavailability. The present technology further provides methods of manufacturing the same. The present technology still further provides pharmaceutical compositions comprising said compounds and methods of treating diseases or conditions using the same.
    Type: Application
    Filed: April 1, 2025
    Publication date: April 9, 2026
    Inventors: Sven Guenther, Travis Mickle, Sanjib Bera, Amarraj Chakraborty
  • Levorphanol prodrugs and processes for making and using them
    Patent number: 12590065
    Abstract: The presently described technology provides compositions of one or more of oxoacids, polyethylene glycols, and vitamin compounds chemically conjugated to levorphanol ((?)-17-methylmorphinan-3-ol) to form novel prodrugs and compositions of levorphanol.
    Type: Grant
    Filed: April 12, 2018
    Date of Patent: March 31, 2026
    Assignee: Zevra Therapeutics, Inc.
    Inventors: Travis Mickle, Sven Guenther, Sanjib Bera
  • USE OF ARIMOCLOMOL IN ACTIVATING CLEAR GENE EXPRESSION AS TREATMENT FOR LYSOSOMAL STORAGE DISORDERS
    Publication number: 20260000661
    Abstract: The present disclosure provides methods of treating lysosomal storage disorders such as Niemann-Pick Disease, Type-C, by administering a therapeutically effective amount of arimoclomol in combination with miglustat. The present disclosure further provides methods of removing lysosomal cholesterol by administering the same.
    Type: Application
    Filed: June 30, 2025
    Publication date: January 1, 2026
    Inventors: Sven Guenther, Travis Mickle, Thomas Kirkegaard Jensen
  • USE OF ARIMOCLOMOL IN ACTIVATING CLEAR GENE EXPRESSION AS TREATMENT FOR LYSOSOMAL STORAGE DISORDERS
    Publication number: 20260000662
    Abstract: The present disclosure provides methods of treating lysosomal storage disorders such as Niemann-Pick Disease, Type-C, by administering a therapeutically effective amount of arimoclomol. The present disclosure further provides methods of removing lysosomal cholesterol by administering the same.
    Type: Application
    Filed: June 30, 2025
    Publication date: January 1, 2026
    Inventors: Sven Guenther, Travis Mickle, Thomas Kirkegaard Jensen
  • SERDEXMETHYLPHENIDATE FOR TREATMENT OF IDIOPATHIC HYPERSOMNIA
    Publication number: 20250375436
    Abstract: The present technology relates to a method of treating sleep disorders in a patient, the method comprising: administering to the patient before bedtime a composition comprising a therapeutically effective amount of a conjugate of d-methylphenidate having a structure of Formula I or a pharmaceutically acceptable salt thereof, wherein the composition comprising the conjugate of d-methylphenidate is administered about 0-3 hours before the bedtime of the patient.
    Type: Application
    Filed: March 24, 2025
    Publication date: December 11, 2025
    Inventors: Sven Guenther, Travis Mickle, Rene Braeckman, Guochen Chi
  • GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM
    Publication number: 20250367299
    Abstract: Disclosed are one or more compounds comprising chemically modified gamma-hydroxybutyrate (GHB), 2-hydroxytetrahydrofuran, and/or 1,4-butanediol, and salts of such compounds (GHB delivering compounds and salts thereof). Also disclosed are compositions comprising at least one GHB delivering compound, or a salt thereof, methods of making such compounds, and methods of using such GHB delivering compounds and compositions. Methods of treatment using the compounds are also disclosed.
    Type: Application
    Filed: June 16, 2025
    Publication date: December 4, 2025
    Inventors: Sanjib BERA, Dibyendu DANA, Sven GUENTHER, Adam SMITH, Travis MICKLE
  • GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM
    Publication number: 20250186591
    Abstract: Disclosed are one or more compounds comprising chemically modified gamma-hydroxybutyrate (GHB), 2-hydroxytetrahydrofuran, and/or 1,4-butanediol, and salts of such compounds (GHB delivering compounds and salts thereof). Also disclosed are compositions comprising at least one GHB delivering compound, or a salt thereof, methods of making such compounds, and methods of using such GHB delivering compounds and compositions. Methods of treatment using the compounds are also disclosed.
    Type: Application
    Filed: February 13, 2025
    Publication date: June 12, 2025
    Inventors: Sanjib BERA, Sven GUENTHER, Adam SMITH, Travis MICKLE
  • Gamma-hydroxybutyrate delivering compounds and processes for making and using them
    Patent number: 12251445
    Abstract: Disclosed are one or more compounds comprising chemically modified gamma-hydroxybutyrate (GHB), 2-hydroxytetrahydrofuran, and/or 1,4-butanediol, and salts of such compounds (GHB delivering compounds and salts thereof). Also disclosed are compositions comprising at least one GHB delivering compound, or a salt thereof, methods of making such compounds, and methods of using such GHB delivering compounds and compositions. Methods of treatment using the compounds are also disclosed.
    Type: Grant
    Filed: April 19, 2023
    Date of Patent: March 18, 2025
    Inventors: Sanjib Bera, Sven Guenther, Adam Smith, Travis Mickle
  • LEVORPHANOL PRODRUGS AND PROCESSES FOR MAKING AND USING THEM
    Publication number: 20250032479
    Abstract: The presently described technology provides compositions of one or more of oxoacids, amino acids, polyethylene glycols, and/or vitamin compounds chemically conjugated to levorphanol ((-)-17-methylmorphinan-3-ol) to form novel prodrugs and compositions of levorphanol.
    Type: Application
    Filed: July 29, 2024
    Publication date: January 30, 2025
    Inventors: Travis Mickle, Sven Guenther, Sanjib Bera
  • DEXTRORPHAN PRODRUGS AND PROCESSES FOR MAKING AND USING THEM
    Publication number: 20240317688
    Abstract: The presently described technology provides compositions of one or more of oxoacids, polyethylene glycols, and vitamin compounds chemically conjugated to dextrorphan, (+)-17-methylmorphinan-3-ol), to form novel prodrugs and compositions of levorphanol.
    Type: Application
    Filed: May 6, 2024
    Publication date: September 26, 2024
    Inventors: Travis Mickle, Sven Guenther, Sanjib Bera
  • D-amphetamine compounds, compositions, and processes for making and using the same
    Patent number: 12091386
    Abstract: Disclosed are d-amphetamine compounds and compositions comprising at least one organic acid covalently bound to d-amphetamine, having the structure of a salt thereof, a derivative thereof, or a combination thereof. Methods of making and using the same are also disclosed.
    Type: Grant
    Filed: October 13, 2021
    Date of Patent: September 17, 2024
    Assignee: ZEVRA THERAPEUTICS, INC.
    Inventors: Sven Guenther, Guochen Chi, Travis Mickle
  • Levorphanol prodrugs and processes for making and using them
    Patent number: 12076316
    Abstract: The presently described technology provides compositions of one or more of oxoacids, amino acids, polyethylene glycols, and/or vitamin compounds chemically conjugated to levorphanol ((?)-17-methylmorphinan-3-ol) to form novel prodrugs and compositions of levorphanol.
    Type: Grant
    Filed: December 14, 2021
    Date of Patent: September 3, 2024
    Inventors: Travis Mickle, Sven Guenther, Sanjib Bera
  • D-AMPHETAMINE COMPOUNDS, COMPOSITIONS, AND PROCESSES FOR MAKING AND USING THE SAME
    Publication number: 20240199551
    Abstract: Discloses are d-amphetamine compounds and compositions comprising at least on organic acid covalently bound to d-amphetamine, having the structure of Formula I, a salt thereof, a derivative thereof, or a combination thereof. Methods of making and using the same are also disclosed.
    Type: Application
    Filed: February 5, 2024
    Publication date: June 20, 2024
    Inventors: Sven Guenther, Guochen Chi, Travis Mickle
  • Dextrorphan prodrugs and processes for making and using them
    Patent number: 12012384
    Abstract: The presently described technology provides compositions of one or more of oxoacids, polyethylene glycols, and/or vitamin compounds chemically conjugated to dextrorphan, (+)-17-methylmorphinan-3-ol), to form novel prodrugs and compositions of dextrorphan.
    Type: Grant
    Filed: November 29, 2021
    Date of Patent: June 18, 2024
    Assignee: ZEVRA THERAPEUTICS, INC.
    Inventors: Travis Mickle, Sven Guenther, Sanjib Bera
  • GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM
    Publication number: 20230382851
    Abstract: Disclosed are one or more compounds comprising chemically modified gamma-hydroxybutyrate (GHB), 2-hydroxytetrahydrofuran, and/or 1,4-butanediol, and salts of such compounds (GHB delivering compounds and salts thereof). Also disclosed are compositions comprising at least one GHB delivering compound, or a salt thereof, methods of making such compounds, and methods of using such GHB delivering compounds and compositions. Methods of treatment using the compounds are also disclosed.
    Type: Application
    Filed: April 19, 2023
    Publication date: November 30, 2023
    Inventors: Sanjib BERA, Dibyendu DANA, Sven GUENTHER, Adam SMITH, Travis MICKLE
  • GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM
    Publication number: 20230382881
    Abstract: Disclosed are one or more compounds comprising chemically modified gamma-hydroxybutyrate (GHB), 2-hydroxytetrahydrofuran, and/or 1,4-butanediol, and salts of such compounds (GHB delivering compounds and salts thereof). Also disclosed are compositions comprising at least one GHB delivering compound, or a salt thereof, methods of making such compounds, and methods of using such GHB delivering compounds and compositions. Methods of treatment using the compounds are also disclosed.
    Type: Application
    Filed: April 19, 2023
    Publication date: November 30, 2023
    Inventors: Sanjib BERA, Dibyendu DANA, Sven GUENTHER, Adam SMITH, Travis MICKLE
  • GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM
    Publication number: 20230382880
    Abstract: Disclosed are one or more compounds comprising chemically modified gamma-hydroxybutyrate (GHB), 2-hydroxytetrahydrofuran, and/or 1,4-butanediol, and salts of such compounds (GHB delivering compounds and salts thereof). Also disclosed are compositions comprising at least one GHB delivering compound, or a salt thereof, methods of making such compounds, and methods of using such GHB delivering compounds and compositions. Methods of treatment using the compounds are also disclosed.
    Type: Application
    Filed: April 19, 2023
    Publication date: November 30, 2023
    Inventors: Sanjib BERA, Sven GUENTHER, Adam SMITH, Travis MICKLE
  • KETAMINE COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM
    Publication number: 20230355550
    Abstract: Disclosed are compounds comprising ketamine (2-(2-chlorophenyl)-2-(methylamino)-cyclohexanone) chemically conjugated to one or more oxoacids, amino acids, polyethylene glycols (PEG or PEO), peptides, phosphates, and/or vitamin compounds, and salts of such compounds. Also disclosed are compositions comprising at least one ketamine compound, or a salt thereof, methods of making such compounds, and methods of using such ketamine compounds and compositions.
    Type: Application
    Filed: July 20, 2023
    Publication date: November 9, 2023
    Inventors: Guochen CHI, Sven GUENTHER, Travis MICKLE, Adam SMITH
  • GAMMA-HYDROXYBUTYRATE DELIVERING COMPOUNDS AND PROCESSES FOR MAKING AND USING THEM
    Publication number: 20230338543
    Abstract: Disclosed are compounds comprising chemically modified gamma-hydroxybutyrate (GHB), 2-hydroxytetrahydrofuran, and/or 1,4-butanediol, and salts of such compounds (GHB delivering compounds and salts thereof). Also disclosed are compositions comprising at least one GHB delivering compound, or a salt thereof, methods of making such compounds, and methods of using such GHB delivering compounds and compositions.
    Type: Application
    Filed: April 19, 2023
    Publication date: October 26, 2023
    Inventors: Sanjib BERA, Dibyendu DANA, Sven GUENTHER, Adam SMITH, Travis MICKLE
  • Ketamine compounds and processes for making and using them
    Patent number: 11753378
    Abstract: Disclosed are compounds comprising ketamine (2-(2-chlorophenyl)-2-(methylamino)-cyclohexanone) chemically conjugated to one or more oxoacids, amino acids, polyethylene glycols (PEG or PEO), peptides, phosphates, and/or vitamin compounds, and salts of such compounds. Also disclosed are compositions comprising at least one ketamine compound, or a salt thereof, methods of making such compounds, and methods of using such ketamine compounds and compositions.
    Type: Grant
    Filed: April 18, 2022
    Date of Patent: September 12, 2023
    Assignee: Zevra Therapeutics, Inc.
    Inventors: Guochen Chi, Sven Guenther, Travis Mickle, Adam Smith