Abstract: The present invention is related to the field of therapeutic delivery platforms. Such therapeutic delivery platforms are based upon the formation of proteinacous exovesicles that bind nucleic acid payloads (e.g., mRNA, siRNA, shRNA etc.). These nucleic acid payloads may hind to the proteinacous vesicle either directly or as an adduct of a linker molecule. As one example, the linker molecule may be an arc 3?UTR that is bound to an Arc protein exovesicle.

Abstract: A method of modeling the operation of a HEP system for an aircraft is provided. The HEP system includes a gas turbine engine and an electric motor. The method includes: modeling the operation of a HEP system using an engine model with a plurality of modules. Each module is configured with executable instructions to receive an input operational parameter and produce an output operational parameter. The input operational parameters include one or more of an input pressure, temperature, mass flow, or power, and the output operational parameters include one or more of an output pressure, temperature, mass flow, or power. The modeling includes providing a first output operational parameter from a first module to a second module as a first input operational parameter, and using the second module to produce a second output operational parameter using the first input operational parameter.

Abstract: The present invention is related to the field of therapeutic delivery platforms. Such therapeutic delivery platforms are based upon the formation of proteinacous exovesicles that bind nucleic acid payloads (e.g., mRNA, siRNA, shRNA etc.). These nucleic acid payloads may hind to the proteinacous vesicle either directly or as an adduct of a linker molecule. As one example, the linker molecule may be an arc 3?UTR that is bound to an Arc protein exovesicle.