Patents by Inventor Travis Wilson

Travis Wilson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination therapies using cyclosporine and aromatic cationic peptides
    Patent number: 10702577
    Abstract: The invention provides compositions and methods for preventing or treating an ischemia-reperfusion injury, such as occurs during acute myocardial infarction and organ transplant in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide or a pharmaceutically acceptable salt thereof, and one or more additional active agents such as cyclosporine.
    Type: Grant
    Filed: January 3, 2017
    Date of Patent: July 7, 2020
    Assignee: STEALTH BIOTHERAPEUTICS CORP
    Inventor: D. Travis Wilson
  • Pharmaceutically relevant aromatic-cationic peptides
    Patent number: 10696716
    Abstract: The present technology provides peptides, methods of generating the peptides, and pharmaceutically acceptable salts of the peptides. In some embodiments, the peptide is D-Arg-2?6?-Dmt-Lys-Phe-NH2.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: June 30, 2020
    Assignee: STEALTH BIOTHERAPEUTICS CORP
    Inventor: D. Travis Wilson
  • UTILITY VEHICLE HAVING COLLAPSIBLE GAME HANGER APPARATUS
    Publication number: 20200165110
    Abstract: A utility vehicle having a collapsible game hanger apparatus includes a cargo box, a hitch receiver disposed under the cargo box and included in a rear structure, a hoist structure, a winch device, and a winch mounting bracket. The hoist structure consists of a base bar detachably attached to the hitch receiver, a mast attached to an end portion of the base bar, and a boom attached to an upper end of the mast. The winch device consists essentially of a winch detachably attached to a winch mounting bracket and a pulley unit for guiding the winch cable.
    Type: Application
    Filed: November 27, 2018
    Publication date: May 28, 2020
    Applicant: KUBOTA CORPORATION
    Inventors: Travis WILSON, Aubrey JARVIS
  • Methods and compositions for the treatment of neuropathy and hyperalgesia
    Patent number: 10646539
    Abstract: The disclosure relates to methods for treating a subject suffering from hyperalgesia caused by drug-induced neuropathy by administering to the subject an effective amount of an aromatic-cationic peptide. The disclosure also relates to methods for protecting a subject from hyperalgesia caused by drug-induced neuropathy by administering an effective amount of an aromatic-cationic peptide to a subject at risk for developing the condition.
    Type: Grant
    Filed: April 22, 2019
    Date of Patent: May 12, 2020
    Assignee: STEALTH BIOTHERAPEUTICS CORP
    Inventor: D. Travis Wilson
  • Processes for preparing pharmaceutically relevant peptides
    Patent number: 10633415
    Abstract: The present technology provides methods of generating the peptides, and pharmaceutically acceptable salts of the peptides and intermediates thereof. In some embodiments, the peptide is D-Arg-2?6?-Dmt-Lys-Phe-NH2.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: April 28, 2020
    Assignee: STEALTH BIOTHERAPEUTICS CORP
    Inventors: Scott Duncan, D. Travis Wilson
  • Methods of identifying and monitoring mitochondrial dysfunction using monocyte screening
    Patent number: 10627392
    Abstract: The present technology provides methods for detecting and diagnosing diseases and conditions characterized by mitochondrial dysfunction using monocytes as an indicator of the dysfunction.
    Type: Grant
    Filed: June 17, 2015
    Date of Patent: April 21, 2020
    Assignee: Stealth Biotherapeutics Corp
    Inventor: D. Travis Wilson
  • METHODS AND COMPOSITIONS FOR REGULATING SRCA2A EXPRESSION LEVELS IN MYOCARDIAL INFARCTION
    Publication number: 20200113966
    Abstract: The disclosure provides methods and compositions for increasing SERCA2a expression levels in a mammalian subject in need thereof. The methods comprise administering to the subject a therapeutic amount of an aromatic-cationic peptide to subjects in need thereof. In some embodiments, the aromatic-cationic peptide is D-Arg-2?6?-Dmt-Lys-Phe-NH2, or a pharmaceutically acceptable salt thereof such as acetate or trifluoroacetate salt. In some embodiments, the subject has suffered a myocardial infarction.
    Type: Application
    Filed: June 11, 2019
    Publication date: April 16, 2020
    Applicant: Stealth BioTherapeutics Corp.
    Inventors: D. Travis Wilson, Robert A. Kloner
  • Therapeutic compositions including frataxin, lactoferrin, and mitochondrial energy generating enzymes, and uses thereof
    Patent number: 10576124
    Abstract: Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of a therapeutic biological molecule, and/or naturally or artificially occurring derivatives, analogues, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide). The present technology provides compositions related to aromatic-cationic peptides linked to a therapeutic biological molecule and uses of the same. In some embodiments, the aromatic-cationic peptide comprises 2?,6?-dimethyl-Tyr-D-Arg-Phe-Lys-NH2, Phe-D-Arg-Phe-Lys-NH2, or D-Arg-2?,6?-Dmt-Lys-Phe-NH2.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: March 3, 2020
    Assignee: STEALTH BIOTHERAPEUTICS CORP
    Inventor: D. Travis Wilson
  • PHARMACEUTICALLY RELEVANT AROMATIC-CATIONIC PEPTIDES
    Publication number: 20200024308
    Abstract: The present technology provides peptides, methods of generating the peptides, and pharmaceutically acceptable salts of the peptides. In some embodiments, the peptide is D-Arg-2?6?-Dmt-Lys-Phe-NH2.
    Type: Application
    Filed: February 28, 2019
    Publication date: January 23, 2020
    Applicant: STEALTH BIOTHERAPEUTICS CORP
    Inventor: D. Travis Wilson
  • METHODS AND COMPOSITIONS FOR DETECTING AND DIAGNOSING DISEASES AND CONDITIONS
    Publication number: 20200017911
    Abstract: The disclosure provides methods for detecting and diagnosing diseases and conditions associated with defects in cardiolipin remodeling. In some embodiments, the present technology relates to methods for detecting the presence or amount of cardiolipin isoforms and/or the presence or amount of enzymes involved in cardiolipin remodeling.
    Type: Application
    Filed: August 10, 2018
    Publication date: January 16, 2020
    Inventor: D. Travis Wilson
  • Methods for the regulation of matrix metalloproteinase expression
    Patent number: 10525098
    Abstract: The disclosure provides methods of reducing MMP-9 expression and/or MMP-9 activity in a mammalian subject. The disclosure also provides methods of increasing TIMP-1 expression and/or TIMP-1 activity in a mammalian subject. The methods comprise administering a therapeutically effective amount of an aromatic-cationic peptide to a subject in need thereof.
    Type: Grant
    Filed: January 29, 2018
    Date of Patent: January 7, 2020
    Assignee: STEALTH BIOTHERAPEUTICS CORP
    Inventors: D. Travis Wilson, Robert A. Kloner
  • METHODS FOR TREATMENT OF ATHEROSCLEROSIS
    Publication number: 20200000870
    Abstract: Disclosed herein are methods and compositions for preventing or treating atherosclerosis in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide and, in some applications, a second active agent, to subjects in need thereof. The present technology relates to the treatment or prevention of atherosclerosis in mammals through the administration of a therapeutically effective amount of aromatic cationic peptides and, in some embodiments, a second active agent.
    Type: Application
    Filed: February 8, 2019
    Publication date: January 2, 2020
    Inventors: D. Travis Wilson, Mark Bamberger, Brian Blakey
  • METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF FRIEDREICH'S ATAXIA
    Publication number: 20190388493
    Abstract: The disclosure provides methods of preventing or treating Friedreich's ataxia in a mammalian subject, reducing risk factors, signs and/or symptoms associated with Friedreich's ataxia, and/or reducing the likelihood or severity of Friedreich's ataxia. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to e.g., reduce oxidative stress, increase mitochondrial metabolism, or a combination thereof.
    Type: Application
    Filed: May 29, 2019
    Publication date: December 26, 2019
    Inventor: D. Travis Wilson
  • PEPTIDE THERAPEUTICS AND METHODS FOR USING SAME
    Publication number: 20190374596
    Abstract: Disclosed herein are methods and compositions for the treatment and/or prevention of diseases or conditions comprising administration of an MPP, and/or naturally or artificially occurring variants or analogues of an MPP, or pharmaceutically acceptable salts thereof, alone or in combination with one or more active agents (e.g., an aromatic-cationic peptide such as D-Arg-2?6?-Dmt-Lys-Phe-NH2).
    Type: Application
    Filed: May 14, 2019
    Publication date: December 12, 2019
    Applicant: STEALTH BIOTHERAPEUTICS CORP
    Inventor: D. Travis Wilson
  • METHODS FOR PERFORMING A CORONARY ARTERY BYPASS GRAFT PROCEDURE
    Publication number: 20190365845
    Abstract: The invention provides methods of treating an obstructive coronary artery disease in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to subjects in need thereof and performing a coronary artery bypass graft procedure on the subject.
    Type: Application
    Filed: October 23, 2018
    Publication date: December 5, 2019
    Inventors: Kenneth Borow, D. Travis Wilson
  • METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING LEBER'S HEREDITARY OPTIC NEUROPATHY
    Publication number: 20190365846
    Abstract: The disclosure generally describes methods of preventing or treating Lebers hereditary optic neuropathy (LHON). The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof.
    Type: Application
    Filed: November 2, 2018
    Publication date: December 5, 2019
    Applicant: Stealth BioTherapeutics Corp
    Inventor: D. Travis Wilson
  • METHODS FOR THE PREVENTION OR TREATMENT OF LEFT VENTRICLE REMODELING
    Publication number: 20190358286
    Abstract: The disclosure provides methods of preventing, treating, or ameliorating LV remodeling in a mammalian subject. The methods comprise administering to the subject a therapeutic amount of an aromatic-cationic peptide such as D-Arg-2,6-Dmt-Lys-Phe-NH2.
    Type: Application
    Filed: November 15, 2018
    Publication date: November 28, 2019
    Inventors: D. Travis Wilson, Robert A. Kloner
  • METHODS AND COMPOSITIONS FOR THE PREVENTION AND TREATMENT NEUROPATHY
    Publication number: 20190343913
    Abstract: The disclosure relates to methods for treating a subject suffering from hyperalgesia caused by drug-induced neuropathy by administering to the subject an effective amount of an aromatic-cationic peptide. The disclosure also relates to methods for protecting a subject from hyperalgesia caused by drug-induced neuropathy by administering an effective amount of an aromatic-cationic peptide to a subject at risk for developing the condition.
    Type: Application
    Filed: April 22, 2019
    Publication date: November 14, 2019
    Applicant: STEALTH BIOTHERAPEUTICS CORP
    Inventor: D. Travis Wilson
  • METHODS FOR THE PREVENTION OR TREATMENT OF VESSEL OCCLUSION INJURY
    Publication number: 20190336566
    Abstract: This invention provides methods of preventing or treating cardiac ischemia-reperfusion injury in a mammalian subject. The methods comprise administering to the subject an effective amount of an aromatic-cationic peptide to a subject in need thereof, wherein the peptide is D-Arg-2 6-Dmt-Lys-Phe-NH2 (SS-31).
    Type: Application
    Filed: December 5, 2018
    Publication date: November 7, 2019
    Inventors: Kenneth Borow, D. Travis Wilson
  • METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING DOMINANT OPTIC ATROPHY
    Publication number: 20190328822
    Abstract: The disclosure generally describes methods of preventing or treating dominant optic atrophy. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof. The present technology relates generally to the treatment or prevention of Leber's hereditary optic neuropathy (LHON) or dominant optic atrophy (DOA) in mammals through administration of therapeutically effective amounts of aromatic-cationic peptides to subjects in need thereof. In one aspect, the present disclosure provides a method of treating or preventing dominant optic atrophy in a mammalian subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a peptide.
    Type: Application
    Filed: November 28, 2018
    Publication date: October 31, 2019
    Applicant: STEALTH BIOTHERAPEUTICS CORP
    Inventor: D. Travis Wilson