Abstract: Novel methods and apparatus for sorting and enriching target cells of interest from a mixture.

Abstract: Provided are methods, systems, and kits for cell processing, e.g., for therapeutic use, such as for adoptive cell therapy. The provided methods include transduction methods, in which cells and virus are incubated under conditions that result in transduction of the cells with a viral vector. The incubation in some embodiments is carried out in an internal cavity of a generally rigid centrifugal chamber, such as a cylindrical chamber made of hard plastic, the cavity of which may have a variable volume. The methods include other processing steps, including those carried out in such a chamber, including washing, selection, isolation, culture, and formulation. In particular, the disclosure relates to method providing advantages over available processing methods, such as available methods for large-scale processing. Such advantages include, for example, reduced cost, streamlining, increased efficacy, increased safety, and increased reproducibility among different subjects and conditions.

Abstract: Provided are methods, systems, and kits for cell processing, e.g., for therapeutic use, such as for adoptive cell therapy. The provided methods include transduction methods, in which cells and virus are incubated under conditions that result in transduction of the cells with a viral vector. The incubation in some embodiments is carried out in an internal cavity of a generally rigid centrifugal chamber, such as a cylindrical chamber made of hard plastic, the cavity of which may have a variable volume. The methods include other processing steps, including those carried out in such a chamber, including washing, selection, isolation, culture, and formulation. In particular, the disclosure relates to method providing advantages over available processing methods, such as available methods for large-scale processing. Such advantages include, for example, reduced cost, streamlining, increased efficacy, increased safety, and increased reproducibility among different subjects and conditions.

Abstract: Novel methods and apparatus for sorting and enriching target cells of interest from a mixture.

Abstract: Provided are methods, systems, and kits for cell processing, e.g., for therapeutic use, such as for adoptive cell therapy. The provided methods include transduction methods, in which cells and virus are incubated under conditions that result in transduction of the cells with a viral vector. The incubation in some embodiments is carried out in an internal cavity of a generally rigid centrifugal chamber, such as a cylindrical chamber made of hard plastic, the cavity of which may have a variable volume. The methods include other processing steps, including those carried out in such a chamber, including washing, selection, isolation, culture, and formulation. In particular, the disclosure relates to method providing advantages over available processing methods, such as available methods for large-scale processing. Such advantages include, for example, reduced cost, streamlining, increased efficacy, increased safety, and increased reproducibility among different subjects and conditions.

Abstract: Provided are methods, systems, and kits for cell processing, e.g., for therapeutic use, such as for adoptive cell therapy. The provided methods include transduction methods, in which cells and virus are incubated under conditions that result in transduction of the cells with a viral vector. The incubation in some embodiments is carried out in an internal cavity of a generally rigid centrifugal chamber, such as a cylindrical chamber made of hard plastic, the cavity of which may have a variable volume. The methods include other processing steps, including those carried out in such a chamber, including washing, selection, isolation, culture, and formulation. In particular, the disclosure relates to method providing advantages over available processing methods, such as available methods for large-scale processing. Such advantages include, for example, reduced cost, streamlining, increased efficacy, increased safety, and increased reproducibility among different subjects and conditions.

Abstract: Provided are methods, systems, and kits for cell processing, e.g., for therapeutic use, such as for adoptive cell therapy. The provided methods include transduction methods, in which cells and virus are incubated under conditions that result in transduction of the cells with a viral vector. The incubation in some embodiments is carried out in an internal cavity of a generally rigid centrifugal chamber, such as a cylindrical chamber made of hard plastic, the cavity of which may have a variable volume. The methods include other processing steps, including those carried out in such a chamber, including washing, selection, isolation, culture, and formulation. In particular, the disclosure relates to method providing advantages over available processing methods, such as available methods for large-scale processing. Such advantages include, for example, reduced cost, streamlining, increased efficacy, increased safety, and increased reproducibility among different subjects and conditions.

Abstract: To help customers make purchasing decisions, metrics can be measured and displayed to a user. In one embodiment, the metrics displayed include at least a portion of a measured metric over a first period of time, at least a portion of a current metric, and at least a portion of a projected future metric over a second period of time. In one embodiment, a system receives information relating to a target audience or advertisement delivery preferences of an advertiser. The system can display to the user an interface comprising a chart showing at least some historical impressions over a first period of time, at least some current impressions, and at least some projected future proposed impressions over a second period of time. In one embodiment, the user can use the interface to purchase and/or to bid for advertisement placements.

Abstract: A system and method for facilitating take-off from or landing on aircraft on a short runway includes a linear array of individual linear induction motors placed along the short runway. A reaction plate mounted to the aircraft is either accelerated or decelerated by the individual linear induction motors. A control system associated with each individual linear induction motor senses the presence of the aircraft, determines its speed, and applies a predetermined amount of electrical energy to either accelerate or decelerate the aircraft.

Abstract: A system and method for improving the travel efficiency of a train that includes decoupling the last car from a moving train, guiding the last car onto an adjacent track and bringing the decoupled car to a stop. The system and method of the present invention may also be used to move a decoupled car from a stopped position to a primary track where the decoupled car may be coupled to a moving train.

Abstract: A system and method for facilitating take-off from or landing on aircraft on a short runway includes a linear array of individual linear induction motors placed along the short runway. A reaction plate mounted to the aircraft is either accelerated or decelerated by the individual linear induction motors. A control system associated with each individual linear induction motor senses the presence of the aircraft, determines its speed, and applies a predetermined amount of electrical energy to either accelerate or decelerate the aircraft.