Patents by Inventor Trever G. Bivona

Trever G. Bivona has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SHP2 INHIBITOR COMPOSITIONS FOR USE IN TREATING CANCER
    Publication number: 20220031695
    Abstract: The present disclosure provides methods of treating diseases or disorders using allosteric inhibitors of SHP2 and to methods and diagnostic tests for identifying subjects likely to respond to such allosteric inhibitors of SHP2. In particular, the present disclosure provides diagnostic and therapeutic uses related to certain Receptor Tyrosine Kinase (RTK) mutations that are indicative of sensitivity to allosteric SHP2 inhibitors.
    Type: Application
    Filed: April 6, 2021
    Publication date: February 3, 2022
    Inventors: Robert J. NICHOLS, Trever G. BIVONA, Dana NEEL
  • Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
    Patent number: 9895373
    Abstract: Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
    Type: Grant
    Filed: March 23, 2016
    Date of Patent: February 20, 2018
    Assignees: The Regents of the University of California, Icahn School of Medicine at Mount Sinai
    Inventors: Arvin C. Dar, Tirtha K. Das, Martin Sos, Trever G. Bivona, Kevan M. Shokat, Ross L. Cagan
  • SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES AND USES THEREOF
    Publication number: 20160354377
    Abstract: Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
    Type: Application
    Filed: March 23, 2016
    Publication date: December 8, 2016
    Inventors: Arvin C. Dar, Tirtha K. Das, Martin Sos, Trever G. Bivona, Kevan M. Shokat, Ross L. Cagan
  • Substituted pyrazolo[3,4-D]pyrimidines and uses thereof
    Patent number: 9321772
    Abstract: Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: April 26, 2016
    Assignees: The Regents of the University of California, Icahn School of Medicine at Mount Sinai
    Inventors: Arvin C. Dar, Tirtha K. Das, Martin Sos, Trever G. Bivona, Kevan M. Shokat, Ross L. Cagan
  • SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDINES AND USES THEREOF
    Publication number: 20140243357
    Abstract: Presented herein are novel therapeutic compounds and methods of using the same for the treatment of cancers.
    Type: Application
    Filed: February 25, 2014
    Publication date: August 28, 2014
    Applicants: Mount Sinai School of Medicine, The Regents of the University of California
    Inventors: Arvin C. Dar, Tirtha K. Das, Martin Sos, Trever G. Bivona, Kevan M. Shokat, Ross L. Cagan
  • METHODS OF DETECTING AXL AND GAS6 IN CANCER PATIENTS
    Publication number: 20140121126
    Abstract: Described herein, inter alia, are compositions and methods for detecting levels of AXL and GAS6.
    Type: Application
    Filed: October 25, 2013
    Publication date: May 1, 2014
    Applicants: Memorial Sloan-Kettering Cancer Center, The Regents of the University of California
    Inventors: Trever G. Bivona, Charles Sawyers
  • Prenyl-electrostatic switch, and methods of use
    Patent number: 7767417
    Abstract: The present invention relates to a method of identifying compounds as candidate drugs for treatment of cancer by providing a cell expressing a GTPase protein that is regulated by a prenyl-electrostatic switch, contacting the cell with compounds to be evaluated, and selecting compounds able to regulate charge at the prenyl-electrostatic switch in the GTPase protein as candidate drugs for treatment of cancer. Also disclosed are methods of treating cancer in a patient. An isolated antibody which binds to a phosphorylated prenyl-electrostatic switch on a K-Ras4B protein is also disclosed, as is a kit for detecting phosphorylation of a prenyl-electrostatic switch in a K-Ras4B protein which includes a labeled antibody and a device to detect the label. Also disclosed is a method of detecting phosphorylation of a prenyl-electrostatic switch on a K-Ras4B protein in a biological sample.
    Type: Grant
    Filed: April 19, 2005
    Date of Patent: August 3, 2010
    Assignee: New York University
    Inventors: Mark R. Philips, Trever G. Bivona