Patents by Inventor Trevor Gordon Page
Trevor Gordon Page has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10016340Abstract: A method for continuous production of tablets, including providing a contained module comprising at least two inlets, at least one mixing unit, at least one analytical sensor, a tablet press, and at least one outlet for tablets, feeding an active pharmaceutical ingredient (API) to one of the at least two inlets, feeding an excipient to the other of the at least two inlets, mixing the material stream comprising the API and the excipient in the at least one mixing unit, measuring parameters of the contents of the material stream with the at least one analytical sensor upstream of the tablet press, controlling the two inlets and/or the mixing unit in response to the parameters measured, continuously supplying the tablet press with the material stream, controlling the speed of the tablet press in response to the parameters measured upstream of the tablet press, and discharging tablets at the at least one outlet.Type: GrantFiled: July 7, 2016Date of Patent: July 10, 2018Assignee: GEA PROCESS ENGINEERING LIMITEDInventors: Jurgen Boeckx, Trevor Gordon Page, Michel Simon Waldron
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Patent number: 9713575Abstract: The contained module (1) comprises inlets for an active pharmaceutical ingredient (API) and for an excipient. The inlets are in fluid communication with at least one mixing unit (41,46), and the outlet of the tablet press (6) is in fluid communication with the releasable outlet port for tablets. The material stream comprising the API and the excipient is mixed in the mixing units. During operation parameters of the contents of the material stream are measured with one or more analytical sensors upstream of the tablet press. The speed of the tablet press is controlled in response to the parameters measured upstream of the tablet press. The finished tablets are discharged at an outlet of the tablet press (6).Type: GrantFiled: May 7, 2009Date of Patent: July 25, 2017Assignee: GEA PROCESS ENGINEERING LIMITEDInventors: Jurgen Boeckx, Trevor Gordon Page, Michel Simon Waldron
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Publication number: 20160310365Abstract: A method for continuous production of tablets, including providing a contained module comprising at least two inlets, at least one mixing unit, at least one analytical sensor, a tablet press, and at least one outlet for tablets, feeding an active pharmaceutical ingredient (API) to one of the at least two inlets, feeding an excipient to the other of the at least two inlets, mixing the material stream comprising the API and the excipient in the at least one mixing unit, measuring parameters of the contents of the material stream with the at least one analytical sensor upstream of the tablet press, controlling the two inlets and/or the mixing unit in response to the parameters measured, continuously supplying the tablet press with the material stream, controlling the speed of the tablet press in response to the parameters measured upstream of the tablet press, and discharging tablets at the at least one outlet.Type: ApplicationFiled: July 7, 2016Publication date: October 27, 2016Applicant: GEA Pharma Systems LimitedInventors: Jurgen BOECKX, Trevor Gordon PAGE, Michel Simon WALDRON
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Patent number: 8708551Abstract: A continuous granulator comprises a longitudinal granulation chamber having a first end with an inlet for powder material and a binder feed port and a second end with an outlet for granulated product. The granulation chamber comprises at least two parallel rotary shafts provided with granulating elements and forming an angle of from 0 to 70 degrees with the vertical. Each granulating element on a shaft comprises at least one lobe having limited extent in the circumferential direction of the shaft and interleaving with a lobe of a granulating element on another shaft. A plurality of such separate granulating elements are distributed from the inlet to the outlet, and successive granulating elements on a shaft are mutually angled.Type: GrantFiled: April 18, 2006Date of Patent: April 29, 2014Assignee: Collette NVInventors: Ove Emil Hansen, Trevor Gordon Page, Michel Simon Waldron
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Publication number: 20120061869Abstract: The contained module (1) comprises inlets for an active pharmaceutical ingredient (API) and for an excipient. The inlets are in fluid communication with at least one mixing unit (41,46), and the outlet of the tablet press (6) is in fluid communication with the releasable outlet port for tablets. The material stream comprising the API and the excipient is mixed in the mixing units. During operation parameters of the contents of the material stream are measured with one or more analytical sensors upstream of the tablet press. The speed of the tablet press is controlled in response to the parameters measured upstream of the tablet press. The finished tablets are discharged at an outlet of the tablet press (6).Type: ApplicationFiled: May 7, 2009Publication date: March 15, 2012Applicant: GEA Pharma Systems LimitedInventors: Jurgen Boeckx, Trevor Gordon Page, Michel Simon Waldron
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Publication number: 20110208436Abstract: In the method, a series of experiments is performed in order to explore a set of process parameter ranges and/or a set of ingredient ranges of a pharmaceutical processing system. The method comprises step 180, in which a set of process parameter ranges and/or a set of ingredient ranges is selected. In step 182 the series of experiments is run automatically in an integrated continuous pharmaceutical product processing system, in which the set of process parameter ranges and/or said set of ingredient ranges are explored. Measurement data is collected during the experiments taking into account the process dynamics in step 184. In step 186, a set of quality attributes is evaluated relative to at least one target attribute and/or quality attribute of a predetermined set of target attributes and/or quality attributes of a product, respectively. Finally, in step 188, the measurement data is stored.Type: ApplicationFiled: February 25, 2011Publication date: August 25, 2011Applicant: GEA PHARMA SYSTEMS NVInventor: Trevor Gordon PAGE
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Patent number: 7908765Abstract: A continuous granulating and drying apparatus comprises a granulator and a fluid bed dryer. The fluid bed dryer comprises at least two separate processing compartments forming part of a common vessel being provided with radially extending partition walls separating the processing compartments from each other. Each processing compartment has a product inlet and a product outlet. The fluid bed dryer comprises a granulated product supply conduit arranged rotatably to selectively communicate with the product inlet of each separate processing compartment, respectively, and a product discharge conduit arranged rotatably to selectively communicate with the product outlet of each separate processing compartment, respectively. The granulator and the fluid bed dryer are closely coupled.Type: GrantFiled: December 22, 2006Date of Patent: March 22, 2011Assignee: Collette NVInventors: Michel Simon Waldron, Trevor Gordon Page
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Patent number: 7883039Abstract: A continuous granulating and drying apparatus includes a granulator and a dryer. Measurement of product and process parameters is carried out by means of measurement units positioned at critical locations in the apparatus.Type: GrantFiled: February 27, 2007Date of Patent: February 8, 2011Assignee: Collette NVInventors: Michel Simon Waldron, Trevor Gordon Page, Tomas Vermeire
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Patent number: 7776241Abstract: The invention relates to a method and apparatus for producing substantially monodisperse micro particles mainly of heat sensible material using a carrier gas and a drying gas. Relatively dense micro particles with diameters in the range 1-120 ?m with a very narrow span can be obtained.Type: GrantFiled: September 16, 2004Date of Patent: August 17, 2010Assignee: NIRO A/SInventors: Ove Emil Hansen, Trevor Gordon Page
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Patent number: 7727484Abstract: A fluid bed apparatus module (1) comprises an outer wall enclosing a processing chamber (9) and has a lower flange connection (4) and an upper flange connection (5), the lower flange connection being adapted to connection with a flange connection (14) of a supply of fluidising gas, and the upper flange connection being adapted to connection with a flange connection (17) of a filter chamber (18) for gas discharge. At least one partition element (6) is arranged in the processing chamber, so that at least one elongated channel is formed in the processing chamber, thereby defining a plug-flow area, and at least one substantially continuous product inlet (10) and at least one substantially continuous product outlet (11) are arranged in the module. Furthermore, a method comprises changing a first module for a second module in a fluid bed apparatus.Type: GrantFiled: December 23, 2004Date of Patent: June 1, 2010Assignee: Collette NVInventors: Ove Emil Hansen, Trevor Gordon Page, Michel Simon Waldron
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Publication number: 20090100947Abstract: A measuring device (1) comprises a probe body (4) adapted for connection with a process vessel or conduit, so that a process opening (6) of the probe body communicates with the interior of the process vessel or conduit. A front valve (7) is arranged between the process opening and a washing chamber (5) in the probe body, and a probe piston (3) is arranged displaceably in the probe body between a retracted position, in which the probe piston is located behind the front valve (7), inside the washing chamber (5), and an extended position, in which the probe piston extends through the front valve and communicates with the process opening. A back valve (9) is arranged between the front valve and the washing chamber, and an intermediate chamber (8) is arranged between the front valve and the back valve. In its retracted position, the probe piston is located behind the back valve.Type: ApplicationFiled: December 5, 2006Publication date: April 23, 2009Applicant: AEROMATIC-FIELDER AGInventor: Trevor Gordon Page
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Publication number: 20080203200Abstract: A continuous granulating and drying apparatus comprises a granulator and a dryer. Measurement of product and process parameters is carried out by means of measurement units positioned at critical locations in the apparatus.Type: ApplicationFiled: February 27, 2007Publication date: August 28, 2008Applicant: Collette NVInventors: Michel Simon Waldron, Trevor Gordon Page, Tomas Vermeire
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Publication number: 20080159067Abstract: A continuous granulator comprises a longitudinal granulation chamber having a first end with an inlet for powder material and a binder feed port and a second end with an outlet for granulated product. The granulation chamber comprises at least two parallel rotary shafts provided with granulating elements and forming an angle of from 0 to 70 degrees with the vertical. Each granulating element on a shaft comprises at least one lobe having limited extent in the circumferential direction of the shaft and interleaving with a lobe of a granulating element on another shaft. A plurality of such separate granulating elements are distributed from the inlet to the outlet, and successive granulating elements on a shaft are mutually angled.Type: ApplicationFiled: April 18, 2006Publication date: July 3, 2008Applicant: COLLETTE NVInventors: Ove Emil Hansen, Trevor Gordon Page, Michel Simon Waldron
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Publication number: 20080148594Abstract: A continuous granulating and drying apparatus comprises a granulator and a fluid bed dryer. The fluid bed dryer comprises at least two separate processing compartments forming part of a common vessel being provided with radially extending partition walls separating the processing compartments from each other. Each processing compartment has a product inlet and a product outlet. The fluid bed dryer comprises a granulated product supply conduit arranged rotatably to selectively communicate with the product inlet of each separate processing compartment, respectively, and a product discharge conduit arranged rotatably to selectively communicate with the product outlet of each separate processing compartment, respectively. The granulator and the fluid bed dryer are closely coupled.Type: ApplicationFiled: December 22, 2006Publication date: June 26, 2008Applicant: Collette NVInventors: Michel Simon Waldron, Trevor Gordon Page
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Publication number: 20080107570Abstract: A fluid bed apparatus module (1) comprises an outer wall enclosing a processing chamber (9) and has a lower flange connection (4) and an upper flange connection (5), the lower flange connection being adapted to connection with a flange connection (14) of a supply of fluidising gas, and the upper flange connection being adapted to connection with a flange connection (17) of a filter chamber (18) for gas discharge. At least one partition element (6) is arranged in the processing chamber, so that at least one elongated channel is formed in the processing chamber, thereby defining a plug-flow area, and at least one substantially continuous product inlet (10) and at least one substantially continuous product outlet (11) are arranged in the module. Furthermore, a method comprises changing a first module for a second module in a fluid bed apparatus.Type: ApplicationFiled: December 23, 2004Publication date: May 8, 2008Applicant: COLLETTE NVInventors: Ove Emil Hansen, Trevor Gordon Page, Michel Simon Waldron