Patents by Inventor Trevor J. Trust

Trevor J. Trust has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combinant polypeptide for use in the manufacture of vaccines against induced diarrhea and to reduce colonization
    Patent number: 6987176
    Abstract: This invention comprises a recombinant protein comprising the maltose binding protein (MBP) of Escherichia coli fused to amino acids 5–337 of the FlaA flagellin of Campylobacter coli VC167 which has provided evidence of immunogenicity and protective efficacy against challenge by a heterologous strain of campylobacter, Campylobacter jejuni 81–176 in mammals. The invention further comprises a recombinant DNA construct encoding the immunodominant region (region I through III) of flagellin from Campylobacter spp. for use as a component of a vaccine against Campylobacter diarrhea. The invention therefore represents an effective treatment against Campylobacter but avoids inducing the autoimmune Guillain Barre Syndrome (GBS), a post-infection polyneuropathy caused by Campylobacter molecular mimicry of human gangliosides which has hampered the development of vaccines heretofore.
    Type: Grant
    Filed: November 12, 1999
    Date of Patent: January 17, 2006
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Patricia Guerry, Lanfong H. Lee, Edward Burg, Trevor J. Trust
  • Specific oligonucleotide primers for detection of pathogenic campylobacter bacteria by polymerase chain reaction
    Patent number: 5494795
    Abstract: This invention is a specific set of oligonucleotide PCR primers (pg50 and pg3) and a specific oligonucleotide probe (pBA273) for detection of PCR-amplified DNA from pathogenic strains of Campylobacter, specifically C. coli and C. jejuni, in fecal specimens.
    Type: Grant
    Filed: May 5, 1993
    Date of Patent: February 27, 1996
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventors: Patricia Guerry, Trevor J. Trust