Abstract: Disclosed are devices and methods for facilitating directed delivery of a medicament into a human organ of a patient. An apparatus to facilitate directed delivery of a medicament into a human organ of a patient may include a container configured to enclose the medicament, a needle having a passage therethrough and a sharp distalmost tip, and a needle guard at least partially surrounding a shaft of the needle. The needle guard may include a distal surface, wherein the sharp distalmost tip of the needle may be configured to extend through an opening in the distal surface. The needle guard may be moveable relative to the needle along an axis of the needle to control a distance from the distal surface to the distalmost tip of the needle.

Abstract: Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening. The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.

Abstract: Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.

Abstract: A drug delivery device is disclosed, wherein the device comprises a housing; a cap located at a proximal end of the housing, the cap including a first pair of deflectable arms and a second pair of deflectable arms; a product vessel arranged in the housing, and a needle coupled to a distal end of the product vessel; a plunger rod for dispensing a product from the product vessel, wherein the plunger rod is slidably received within the cap and partially disposed inside the product vessel; and a needle cover at least partially disposed in the housing, wherein the first pair of deflectable arms are configured to deflect radially inwards towards the plunger rod and the second pair of deflectable arms are configured to radially outwards away from the plunger rod.

Abstract: An injection device includes a carrier, a needle, a driver coupled to the needle, the driver being slidable relative to the carrier between a retracted configuration and a deployed configuration, a shuttle configured to move the driver between the retracted configuration and the deployed configuration, and a stop configured to move from a first configuration to a second configuration, wherein the stop is configured to maintain the driver in the deployed configuration, and movement of the stop from the first configuration to the second configuration allows the shuttle to move the driver from the deployed configuration to the retracted configuration.

Abstract: An auto-injector may include a container capable of comprising a medicament; a shuttle coupled to the container and on a horizontal path with a first state and a second state; an energy source configured to release energy to translate the container and to translate the shuttle, preferably the energy source is pressurized fluid from a can; an impediment preventing horizontal movement of the shuttle before activation of the auto-injector; and a needle having a first end configured to extend out of the auto-injector, and a second end configured to extend into the container, wherein the second end of the needle and the container are not in fluid communication with one another before activation of the auto-injector.

Abstract: An injection device may include a housing, a container disposed within the housing, the container enclosing a fluid and having a first end and a second end, a conduit movable relative to the container, wherein the conduit is not in fluid communication with the fluid enclosed by the container while in a first position, and is in fluid communication with the fluid enclosed by the container and configured to deliver the fluid from the container to a patient while in a second position, and a lock that is removable from the housing, the lock having a first portion and a second portion.

Abstract: Needle spacers for use in administering subcutaneous injections, as well as subcutaneous injection systems including such needle spacers, are disclosed. In certain embodiments, the needle spacer comprises a first portion configured to engage a hub of a needle that comprises such a hub; and a second portion coupled to the first portion and extending distally therefrom, the second portion including a skin-contacting surface disposed on a distal end thereof, wherein the skin-contacting surface is configured to engage a surface of skin of a subject. The second portion is configured to maintain a predetermined distance between the hub of the needle and the surface of the skin, and to permit insertion of the needle to a depth of about 4 mm to about 8 mm below the surface of the skin during administration of a subcutaneous injection via the needle.

Abstract: Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening. The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.

Abstract: An auto-injector may include a container capable of comprising a medicament; a shuttle coupled to the container and on a horizontal path with a first state and a second state; an energy source configured to release energy to translate the container and to translate the shuttle, preferably the energy source is pressurized fluid from a can; an impediment preventing horizontal movement of the shuttle before activation of the auto-injector; and a needle having a first end configured to extend out of the auto-injector, and a second end configured to extend into the container, wherein the second end of the needle and the container are not in fluid communication with one another before activation of the auto-injector.

Abstract: A plunger rod insertion gauge for a precision dose delivery device is disclosed. The insertion gauge includes: an insertion gauge body including a handle portion and a gauge portion; wherein the gauge portion includes one or more plunger rod abutting surfaces and one or more flange abutting surfaces oriented substantially perpendicular to a plunger rod insertion axis; and wherein a dimension measured between the one or more plunger rod abutting surfaces and the one or more flange abutting surfaces defines a maximum plunger rod insertion depth for the precision dose delivery device. Other aspects are described and claimed.

Abstract: A drug delivery device is disclosed, wherein the device comprises a housing; a product container arranged in the housing; a plunger rod partially disposed inside the product container; and a thumb pad configured to receive a portion of the plunger rod, wherein the thumb pad and the plunger rod are configured to transition from a first state to a second state, wherein at the first state, the plunger rod is prevented from moving in a proximal direction, and at the second state, the plunger rod moves freely in a proximal direction.

Abstract: A vial adapter assembly that includes a housing, a first receptacle formed within the housing and configured to receive a first vial within the housing, and a second receptacle formed within the housing and configured to receive a second vial within the housing. An opening of the first receptacle and an opening of the second receptacle is in fluid communication with the upper surface of the housing. The vial adapter assembly includes a cap that is coupled and movable relative to the housing from a closed configuration to an open configuration. In the closed configuration, the cap is configured to cover the opening of the first receptacle and the opening of the second receptacle on the upper surface. In the open configuration, the cap is configured to uncover the opening of the first receptacle and the opening of the second receptacle, and expose the upper surface.

Abstract: A syringe fixture for holding a syringe in a test system, the fixture comprising a main housing comprising a first chamber, a second chamber, and an opening extending from the first chamber to the second chamber, wherein the first chamber comprises a first plurality of walls and a second plurality of walls forming a housing for at least a needle of the syringe, wherein the second chamber is configured to hold at least a flange portion of the syringe and the second chamber comprises a cover to enclose at least the flange portion of the syringe; and a base portion having a support, wherein the base portion is configured to receive a portion of a plunger rod, and wherein the base portion includes at least one geometric feature configured to allow or impart a rotational motion on the portion of the plunger rod received in the base portion.

Abstract: An injection device includes a carrier, a needle, a driver coupled to the needle, the driver being slidable relative to the carrier between a retracted configuration and a deployed configuration, a shuttle configured to move the driver between the retracted configuration and the deployed configuration, and a stop configured to move from a first configuration to a second configuration, wherein the stop is configured to maintain the driver in the deployed configuration, and movement of the stop from the first configuration to the second configuration allows the shuttle to move the driver from the deployed configuration to the retracted configuration.

Abstract: An injection device includes a carrier, a needle, a driver coupled to the needle, the driver being slidable relative to the carrier between a retracted configuration and a deployed configuration, a shuttle configured to move the driver between the retracted configuration and the deployed configuration, and a stop configured to move from a first configuration to a second configuration, wherein the stop is configured to maintain the driver in the deployed configuration, and movement of the stop from the first configuration to the second configuration allows the shuttle to move the driver from the deployed configuration to the retracted configuration.

Abstract: Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.

Abstract: Disclosed herein are delivery devices for delivering a volume of a drug product, placebo product, or other product including a fluid. The devices may include a barrel having a longitudinal axis, a proximal end region, and a distal end region. The proximal end region may include an opening, and the barrel may be configured to receive a drug therein. A plunger rod may be disposed at least partially inside the barrel and protruding from the opening. The plunger rod may include a rack having a plurality of teeth. The device may further include a pinion having a plurality of teeth configured to engage with the plurality of teeth of the rack, and rotation of the pinion against the rack may move at least a part of the plunger rod along the longitudinal axis of the barrel.

Abstract: Disclosed herein are devices and methods for delivering a predetermined volume of a drug substance or other product including a fluid. An exemplary device may include a body configured to receive a drug substance therein, and a plunger rod disposed at least partially inside the body to distally move a stopper in the body. The device may include a component configured to regulate distal movement of the plunger rod in a priming step and in a subsequent delivery step, so that the device may be accurately primed and may accurately dispense a predetermined volume of a drug substance.

Abstract: An auto-injector may include a container capable of comprising a medicament; a shuttle coupled to the container and on a horizontal path with a first state and a second state; an energy source configured to release energy to translate the container and to translate the shuttle, preferably the energy source is pressurized fluid from a can; an impediment preventing horizontal movement of the shuttle before activation of the auto-injector; and a needle having a first end configured to extend out of the auto-injector, and a second end configured to extend into the container, wherein the second end of the needle and the container are not in fluid communication with one another before activation of the auto-injector.