Abstract: An interoperative light therapy apparatus and method are disclosed. The apparatus includes an excitation light source, a plurality of light emitting devices and a plurality of light detecting fibers, wherein the plurality of light emitting devices produce a fluorescence light in cancerous cells of a patient treated with a photosensitizing medication. The fluorescence light is collected by the plurality of detector fibers and a digital spatial image of the cancerous cells is produced. The digital spatial image is useful for targeting the cancerous cells in a subsequent resection procedure. An interoperative light therapy apparatus is disclosed that further include a therapy light source that can deliver therapy light to the cancerous cells using the digital spatial image in the subsequent resection procedure.

Abstract: In some implementations, the device may include an optical diffuser assembly having a plurality of light emitting devices positioned along an axis adjacent to one another and the plurality of light emitting devices are adapted to be selectively addressable to produce an irradiance pattern for each of the plurality of the light emitting devices.

Abstract: A therapy light apparatus and method are disclosed. Also disclosed is an optical assembly comprising a directional light diffuser assembly which comprises a light transmissive hollow elongated tube, an elongated light emitter disposed within the light transmissive hollow elongated tube configured to emit a therapy light, and a reflective coating disposed on a portion of an outer surface of the light transmissive hollow elongated tube configured to reflect the therapy light. Also disclosed is a light delivery apparatus that includes a plurality of a forward directional light diffuser assemblies and rearward a directional light diffuser assemblies.

Abstract: A photodynamic therapy (PDT) apparatus and method are disclosed. The PDT apparatus includes a light flap that includes a plurality of light emitting devices wherein each of the light emitting devices has a plurality of operating states. The plurality of operating states are used to train a neural network model capable of producing a treatment irradiance profile. The method includes using an image of an area of interest for targeted treatment of PDT wherein the image is used an input to the trained neural network model. The neural network model produces a plurality of optimized feature states and the apparatus in turn produces a treatment irradiance profile closely matching the area of interest.

Abstract: In some implementations, a PDT delivery device is disclosed that may include a housing including a handle, a fiber lock orifice, a probe insertion orifice and a tube retraction groove positioned between the fiber lock orifice and the probe insertion orifice. In addition, the PDT delivery device may include an insertion probe having a stepped hollow cylinder positioned within the probe insertion orifice and within the tube retraction groove and having an insertion needle at a distal end. The PDT delivery device may include a fiber locking mechanism and a probe release mechanism selectively movable between an unlock position and a lock position. Also, the PDT delivery device may include a probe retraction mechanism releasably coupled to the insertion probe. Further, the PDT delivery device may include a retraction trigger coupled to the probe retraction mechanism to translate the insertion probe between an insertion position and a retraction position.

Abstract: In some implementations, a PDT system may include a probe assembly having an elongated cylinder having a probe inner diameter and a probe outer diameter optical surface and a probe tip positioned on a distal end, a therapy window positioned proximal the probe tip, a door positioned inside of the elongated cylinder and configured to move between an open position to expose the therapy window and a closed position to seal the therapy window, a balloon positioned within the inner probe diameter, a cylindrical light diffuser position inside of the balloon, and a detector fiber positioned proximate the cylindrical light diffuser.

Abstract: In some implementations, a PDT system may include a probe assembly having an elongated cylinder having a probe inner diameter and a probe outer diameter optical surface and a probe tip positioned on a distal end, a therapy window positioned proximal the probe tip, a door positioned inside of the elongated cylinder and configured to move between an open position to expose the therapy window and a closed position to seal the therapy window, a balloon positioned within the inner probe diameter, a cylindrical light diffuser position inside of the balloon, and a detector fiber positioned proximate the cylindrical light diffuser.

Abstract: In some implementations, the device may include an optical diffuser assembly having a plurality of light emitting devices positioned along an axis adjacent to one another and the plurality of light emitting devices are adapted to be selectively addressable to produce an irradiance pattern for each of the plurality of the light emitting devices.

Abstract: A photodynamic therapy (PDT) apparatus and method are disclosed. The PDT apparatus can include a flexible optical applicator that includes a plurality of light emitting devices for producing an irradiance pattern of therapy light to a target area of a patient. The PDT system includes an optical light controller that includes a computer processor. The method disclosed includes determining a treatment plan based on a plurality of therapy light parameters, photosensitizing drug selection, patient specific parameters, optimized light interval and other relevant parameters. The method further includes monitoring the application of the therapy light against the treatment plan and determining an updated treat plan in the event of a deviation from an initial treatment plan.

Abstract: A therapeutic light delivery apparatus and method are disclosed. The apparatus includes a light source, a plurality of light emitting devices paired with a plurality of light detecting devices, wherein each of the light emitting devices is in optical communication with a channel of a delivery optical switch and each of the plurality of light detection devices is in optical communication with a channel of a detection optical switch. The plurality of light emitting devices are fixedly positioned within an applicator light flap. The system further includes an optical detector in optical communication with the detector optical switch. The system further includes an opto-electronic controller that controls delivery optical switch, the detector optical switch and the light source.

Abstract: An interoperative light therapy apparatus and method are disclosed. The apparatus includes an excitation light source, a plurality of light emitting devices and a plurality of light detecting fibers, wherein the plurality of light emitting devices produce a fluorescence light in cancerous cells of a patient treated with a photosensitizing medication. The fluorescence light is collected by the plurality of detector fibers and a digital spatial image of the cancerous cells is produced. The digital spatial image is useful for targeting the cancerous cells in a subsequent resection procedure. An interoperative light therapy apparatus is disclosed that further include a therapy light source that can deliver therapy light to the cancerous cells using the digital spatial image in the subsequent resection procedure.

Abstract: A photodynamic therapy (PDT) apparatus and method are disclosed. The PDT apparatus can include a flexible optical applicator that includes a plurality of light emitting devices for producing an irradiance pattern of therapy light to a target area of a patient. The PDT system includes an optical light controller that includes a computer processor. The method disclosed includes determining a treatment plan based on a plurality of therapy light parameters, photosensitizing drug selection, patient specific parameters, optimized light interval and other relevant parameters. The method further includes monitoring the application of the therapy light against the treatment plan and determining an updated treat plan in the event of a deviation from an initial treatment plan.

Abstract: A therapeutic light delivery apparatus and method are disclosed. The apparatus includes a light source, a plurality of light emitting devices paired with a plurality of light detecting devices, wherein each of the light emitting devices is in optical communication with a channel of a delivery optical switch and each of the plurality of light detection devices is in optical communication with a channel of a detection optical switch. The plurality of light emitting devices are fixedly positioned within an applicator light flap. The system further includes an optical detector in optical communication with the detector optical switch. The system further includes an opto-electronic controller that controls delivery optical switch, the detector optical switch and the light source.

Abstract: A therapeutic light delivery apparatus and method are disclosed. The apparatus includes a light source and an integrated optical applicator. The integrated optical applicator includes a plurality of light emitting devices and detector fibers fixedly spatially positioned within a flexible matrix material. The light emitting devices can be positioned a predetermined distance from an application side of the integrated optical applicator comprising an accurate and repeatable standoff position. A flexible matrix material is disclosed having a high scattering coefficient to produce a uniform irradiance pattern and predetermined fluence.

Abstract: A photodynamic therapy (PDT) apparatus and method are disclosed. The PDT apparatus includes a light flap that includes a plurality of light emitting devices wherein each of the light emitting devices has a plurality of operating states. The plurality of operating states are used to train a neural network model capable of producing a treatment irradiance profile. The method includes using an image of an area of interest for targeted treatment of PDT wherein the image is used an input to the trained neural network model. The neural network model produces a plurality of optimized feature states and the apparatus in turn produces a treatment irradiance profile closely matching the area of interest.

Abstract: A therapeutic light delivery apparatus and method are disclosed. The apparatus includes a light source and an integrated optical applicator. The integrated optical applicator includes a plurality of light emitting devices and detector fibers fixedly spatially positioned within a flexible matrix material. The light emitting devices can be positioned a predetermined distance from an application side of the integrated optical applicator comprising an accurate and repeatable standoff position. A flexible matrix material is disclosed having a high scattering coefficient to produce a uniform irradiance pattern and predetermined fluence.

Abstract: Embodiments of the present disclosure include a low crosstalk, optical fiber based disturbance detection system that includes single-mode optical fiber (SMF) arranged into dual ring Sagnac interferometer wherein both rings share a common sensing section of optical fiber path length. Certain embodiments further include fiber Bragg gratings (FBG's), circulators and couplers to be able to separate the optical signals of the two rings of the dual ring Sagnac interferometer and to perform processing of their individual signals. Embodiments are also disclosed that enable the position of a physical disturbance, the magnitude of the physical disturbance and the frequency of the physical disturbance to be known.

Abstract: Embodiments of the present disclosure include a low crosstalk, optical fiber based disturbance detection system that includes single-mode optical fiber (SMF) arranged into dual ring Sagnac interferometer wherein both rings share a common sensing section of optical fiber path length. Certain embodiments further include fiber Bragg gratings (FBG's), circulators and couplers to be able to separate the optical signals of the two rings of the dual ring Sagnac interferometer and to perform processing of their individual signals. Embodiments are also disclosed that enable the position of a physical disturbance, the magnitude of the physical disturbance and the frequency of the physical disturbance to be known.

Abstract: Methods and apparatus enable monitoring conditions in a well-bore using multiple cane-based sensors. The apparatus includes an array of cane-based Bragg grating sensors located in a single conduit for use in the well-bore. For some embodiments, each sensor is located at a different linear location along the conduit allowing for increased monitoring locations along the conduit.

Abstract: Methods and apparatus enable monitoring conditions in a well-bore using multiple cane-based sensors. The apparatus includes an array of cane-based Bragg grating sensors located in a single conduit for use in the well-bore. For some embodiments, each sensor is located at a different linear location along the conduit allowing for increased monitoring locations along the conduit.