Patents by Inventor Trevor Percival Castor

Trevor Percival Castor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination HIV therapeutic
    Patent number: 11234932
    Abstract: Embodiments of the present invention are directed to particles having a Bryoid and a HDAC inhibitor for the treatment of latent viral disease.
    Type: Grant
    Filed: November 27, 2019
    Date of Patent: February 1, 2022
    Assignee: APHIOS CORPORATION
    Inventor: Trevor Percival Castor
  • SUPERFLUIDS DISRUPTION OF SACCHAROMYCES CEREVISIAE (YEAST), CELL WALL DISINTEGRATION INTO NANOPARTICLES AND FRACTIONATION INTO BETA-GLUCANS, CHITIN AND MANNANS (MANNOPROTEINS)
    Publication number: 20220010263
    Abstract: The present invention is directed to methods and apparatus for and products from disrupting, removing intracellular proteins, enzymes and nucleic acids, spray drying, lipid extraction, and making nanoparticles of Saccharomyces cerevisiae (yeast) cell wall followed by acid and/or enzymatic hydrolysis to produce Beta (?)-glucans, chitin and mannans (mannoproteins). The process and apparatus feature critical, supercritical, or near critical fluids for disruption of yeast and making yeast cell wall nanoparticles. The product materials retain full activity and are devoid of residual processing chemicals such as solvents, salts, or surfactants.
    Type: Application
    Filed: July 13, 2021
    Publication date: January 13, 2022
    Inventor: Trevor Percival Castor
  • Bryoid Compositions, Methods of Making and Use Thereof
    Publication number: 20210269453
    Abstract: Embodiments of the present invention feature novel Bryoid compositions, methods of making and methods of treating disease.
    Type: Application
    Filed: March 21, 2021
    Publication date: September 2, 2021
    Applicant: Aphios Corporation
    Inventor: Trevor Percival Castor
  • Bryoid compositions, methods of making and use thereof
    Patent number: 10954248
    Abstract: Embodiments of the present invention feature novel Bryoid compositions, methods of making and methods of treating disease.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: March 23, 2021
    Inventor: Trevor Percival Castor
  • Drug delivery system and method for the treatment of neuro-degenerative disease
    Publication number: 20200397701
    Abstract: Embodiments of the present invention are directed to drug delivery systems, dosage forms and methods for the intranasal administration of Bryostatins for the treatment of neuro-degenerative diseases. Inventions of the present application are directed to the treatment of neuro-degenerative diseases such as Hutchinson Disease, Parkinson's disease, Down syndrome and Alzheimer's disease.
    Type: Application
    Filed: November 22, 2019
    Publication date: December 24, 2020
    Inventors: Trevor Percival Castor, Jonathan Steven Alexander
  • Combination therapeutics and methods for the treatment of neurodegenerative and other diseases
    Patent number: 10828276
    Abstract: Embodiments of the present invention are directed to the administration of bryostatins and bryostatins and retinoids for the treatment of disease responsive to increases in alpha secretase activity. Inventions of the present application are directed to the treatment of neuro-degenerative diseases such as Hutchinson Disease, Parkinson's disease, Down's syndrome and Alzheimer's disease and virus latency diseases such as HIV and Herpes, cancers such as prostate, melanomas, lymphomas and renal cancers, esophageal and opthalmic diseases such as glaucoma.
    Type: Grant
    Filed: November 26, 2013
    Date of Patent: November 10, 2020
    Inventor: Trevor Percival Castor
  • Transplantation therapies
    Patent number: 10723744
    Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: July 28, 2020
    Inventors: Jonathan Steven Alexander, April C. Carpenter, Trevor Percival Castor
  • Transplantation Therapies
    Publication number: 20200199145
    Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 25, 2020
    Inventors: Jonathan Steven Alexander, April C. Carpenter, Trevor Percival Castor
  • Transplantation Therapies
    Publication number: 20200199146
    Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: March 5, 2020
    Publication date: June 25, 2020
    Inventors: Jonathan Steven Alexander, April C. Carpenter, Trevor Percival Castor
  • COMBINATION HIV THERAPEUTIC
    Publication number: 20200093742
    Abstract: Embodiments of the present invention are directed to particles having a Bryoid and a HDAC inhibitor for the treatment of latent viral disease.
    Type: Application
    Filed: November 27, 2019
    Publication date: March 26, 2020
    Applicant: Aphios Corporation
    Inventor: Trevor Percival Castor
  • Combination HIV therapeutic
    Patent number: 10493030
    Abstract: Embodiments of the present invention are directed to particles having a Bryoid and a HDAC inhibitor for the treatment of latent viral disease.
    Type: Grant
    Filed: May 23, 2016
    Date of Patent: December 3, 2019
    Assignee: Aphios Corporation
    Inventor: Trevor Percival Castor
  • Drug delivery system and method for the treatment of neuro-degenerative disease
    Patent number: 10485766
    Abstract: Embodiments of the present invention are directed to the oral administration of Bryostatins for the treatment of neuro-degenerative disease.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: November 26, 2019
    Assignees: Aphios Corporation, Board of Supervisors of the Louisiana State University and Agricultural and Mechanical College
    Inventors: Trevor Percival Castor, Jonathan Steven Alexander, Geoffrey Purdum, J. David Rios, Lisa M. Schrott, Theodore A. Tyler, Maria I. Vizcaino
  • BRYOID COMPOSITIONS, METHODS OF MAKING AND USE THEREOF
    Publication number: 20190194222
    Abstract: Embodiments of the present invention feature novel Bryoid compositions, methods of making and methods of treating disease
    Type: Application
    Filed: December 4, 2018
    Publication date: June 27, 2019
    Inventor: Trevor Percival Castor
  • TRANSPLANTATION THERAPIES
    Publication number: 20180291033
    Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.
    Type: Application
    Filed: June 8, 2018
    Publication date: October 11, 2018
    Inventors: Jonathan Steven Alexander, April C. Carpenter, Trevor Percival Castor
  • APPARATUS AND METHODS FOR MAKING NANOSOMES LOADED WITH NUCLEIC ACID
    Publication number: 20180272307
    Abstract: Embodiments of the present invention are directed to an apparatus and methods for making nucleic acid loaded nanosomes. One embodiment of the present invention directed to an apparatus comprises a first containment means for containing a mixture of an aqueous solution of nucleic acid and a phospholipid solution with a supercritical, critical or near critical fluid. The apparatus further comprises injection means in fluid communication with said first containment means for receiving the mixture and releasing the mixture as a stream into a decompression liquid. The apparatus further comprises a decompression vessel in fluid communication with the injection means for holding a decompression liquid and receiving the mixture as a stream. The stream forms one or more nanosomes loaded with a nucleic acid in the decompression liquid.
    Type: Application
    Filed: May 25, 2018
    Publication date: September 27, 2018
    Inventor: Trevor Percival Castor
  • Transplantation therapies
    Patent number: 9994585
    Abstract: Embodiments of the present invention are directed to methods and dosage forms for treating inflammation and rejection in transplantation injuries with Bryostatin-1, Bryostatin-1 analogs and pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: September 30, 2014
    Date of Patent: June 12, 2018
    Assignee: Aphios Corporation
    Inventors: Jonathan Steven Alexander, April C. Carpenter, Trevor Percival Castor
  • Apparatus and methods for making nanosomes loaded with nucleic acid
    Patent number: 9981238
    Abstract: Embodiments of the present invention are directed to an apparatus and methods for making nucleic acid loaded nanosomes. One embodiment of the present invention directed to an apparatus comprises a first containment means for containing a mixture of an aqueous solution of nucleic acid and a phospholipid solution with a supercritical, critical or near critical fluid. The apparatus further comprises injection means in fluid communication with said first containment means for receiving the mixture and releasing the mixture as a stream into a decompression liquid. The apparatus further comprises a decompression vessel in fluid communication with the injection means for holding a decompression liquid and receiving the mixture as a stream. The stream forms one or more nanosomes loaded with a nucleic acid in the decompression liquid.
    Type: Grant
    Filed: August 23, 2011
    Date of Patent: May 29, 2018
    Assignee: Aphios Corporation
    Inventor: Trevor Percival Castor
  • COMBINATION HIV THERAPEUTIC
    Publication number: 20180133155
    Abstract: Embodiments of the present invention are directed to particles having a Bryoid and a HDAC inhibitor for the treatment of latent viral disease.
    Type: Application
    Filed: May 23, 2016
    Publication date: May 17, 2018
    Inventor: Trevor Percival Castor
  • COMBINATION THERAPEUTICS AND METHODS FOR THE TREATMENT OF NEURODEGENERATIVE AND OTHER DISEASES
    Publication number: 20150297555
    Abstract: Embodiments of the present invention are directed to the administration of bryostatins and bryostatins and retinoids for the treatment of disease responsive to increases in alpha secretase activity. Inventions of the present application are directed to the treatment of neuro-degenerative diseases such as Hutchinson Disease, Parkinson's disease, Down's syndrome and Alzheimer's disease and virus latency diseases such as HIV and Herpes, cancers such as prostate, melanomas, lymphomas and renal cancers, esophageal and opthalmic diseases such as glaucoma.
    Type: Application
    Filed: November 26, 2013
    Publication date: October 22, 2015
    Applicant: APHIOS CORPORATION
    Inventor: Trevor Percival CASTOR
  • BRYOID COMPOSITIONS, METHODS OF MAKING AND USE THEREOF
    Publication number: 20150291616
    Abstract: Embodiments of the present invention feature novel Bryoid compositions, methods of making and methods of treating disease
    Type: Application
    Filed: November 26, 2013
    Publication date: October 15, 2015
    Applicant: APHIOS CORPORATION
    Inventor: Trevor Percival Castor