Abstract: A privacy enabled system for managing clinical study participant travel has a database (stores data: clinical study, participant, clinical site and trip data sets) and a graphical user interface that has a Travel Planning Interface and is in data communication with an input device and the database. The data sets include a Study Travel Policy, a Study Visit Schedule (appointment procedure, appointment schedule), a traveler profile, traveler personal data (traveler contact information), a site appointment location associated with the appointment procedure, and site contact information. The travel planning interface receives the trip data set (trip segment data) from the database and the input device. The travel planning interface transmits the trip segment data to and receives booked travel data from a travel booking module, generates an itinerary that has booked travel and trip segment data, and transmits the itinerary according to the traveler contact information and the site contact information.

Abstract: Systems for visualization and management of a travel policy for a clinical study have a study dataset having a first travel policy condition, a study travel policy dataset having a main travel policy and a specialized travel policy, and a GUI having a travel policies interface and a travel policy control. The first travel policy condition may be a country, a clinical site, a traveler policy label, a visit attribute, a visit policy label, and combinations thereof. The specialized travel policy (a country policy, a site policy, a first visit policy, a second visit policy, a custom policy, and combinations thereof) is programmatically associated with the first travel policy condition.

Abstract: Systems and methods for effecting bariatric procedures are disclosed. Each system includes an instrument, a control valve and, optionally, a suction controller. The instrument is in the form of an elongated, flexible sizing tube having a distal end portion including a plurality of apertures. The control valve enables suction to be applied to the patient's stomach via the apertures to drain gastric fluids and to bring adjacent portions of the patient's stomach into engagement with the sizing tube to provide a visually perceptible delineation line along which a portion of the stomach may be resected, sealed and tested.

Abstract: This present invention provides means for cell harvesting and isolation to be carried out with a single apparatus. This represents a more convenient way for the processing of cells compared with known methods and represents a useful development for the manufacture of cell therapies.

Abstract: Systems and methods for effecting bariatric procedures are disclosed. Each system includes an instrument, a control valve and, optionally, a suction controller. The instrument is in the form of an elongated, flexible sizing tube having a distal end portion including a plurality of apertures. The control valve enables suction to be applied to the patient's stomach via the apertures to drain gastric fluids and to bring adjacent portions of the patient's stomach into engagement with the sizing tube to provide a visually perceptible delineation line along which a portion of the stomach may be resected, sealed and tested.

Abstract: A device and method of use for treatment/management of postpartum uterine bleeding or hemorrhage of a patient. The device includes a suction tube having a distal end portion at which an aperture or an array of plural apertures is located and extending about the periphery of the distal portion. A sealing member having a flexible sidewall whose outer surface is of a generally conical, bulbous, or cylindrical shape is mounted on the suction tube and extends distally from the apex of the sealing member so that a portion of its sidewall can be brought into engagement with tissue outside of the uterus. Suction from a vacuum source is applied to a proximal end portion of the suction tube to apply suction via the aperture(s) to the interior of the patient's uterus.

Abstract: Disclosed herein are nucleic acid molecules encoding a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a SARS-CoV-2 infection in a subject.

Abstract: A step path for an exercise device includes a support zone, a return zone, and a transition zone between the support zone and the return zone. In the support zone, a front end of a movable step is supported by a front track guide and a rear end of the movable step is supported by a rear track guide. A transition element supports the rear end of the step between the rear guide track and a base guide track, thereby lowering the step-up height of the exercise device.

Abstract: In examples, there is a device for converting ammonia (NH3) in a human breath sample to nitric oxide (NO). The device comprises a tube and a heater. The tube comprises an inlet, an outlet, and a wall defining an internal surface of the tube and an external surface of the tube. The wall comprises substantially the same material along a thickness from the internal surface of the tube to the external surface of the tube. The material is catalytic for conversion of ammonia to nitric oxide. The heater is configured to heat the wall.

Abstract: Disclosed herein are methods of delivering an agent to a subject. Further disclosed herein are methods of treating a disease or disorder in a subject. The methods may include administering to the subject a chondroitinase polypeptide or a polynucleotide encoding a chondroitinase polypeptide in an amount sufficient to degrade glycosaminoglycans, and administering to the subject the agent. The methods may further include administering a hyaluronidase polypeptide or a polynucleotide encoding a hyaluronidase.

Abstract: The present invention relates to a method for purification of viral vectors, more closely it relates to purification of viral vectors from producer cells by using a single automated process. The method comprises the following steps: a) adding producer cells and cell lysis buffer to a processing container; b) mixing said producer cells and cell lysis buffer in said processing container to obtain a mixture; c) flowing said mixture through a chromatography column for purification of viral vectors, wherein the viral vectors are adsorbed on said chromatography column; and d) eluting viral vectors from the chromatography column into a product container.

Abstract: Systems and methods for effecting bariatric procedures are disclosed. Each system includes an instrument, a control valve and, optionally, a suction controller. The instrument is in the form of an elongated, flexible member having a distal end portion arranged for anchoring the instrument in the patient's stomach and for enabling fluids to be removed from the patient's stomach. Suction is applied to the patient's stomach by the distal end portion of the instrument to drain gastric fluids and to bring adjacent portions of the patient's stomach into engagement with the instrument to provide a visually perceptible delineation line along which a portion of the stomach may be resected, sealed and tested.

Abstract: Systems and methods for effecting bariatric procedures are disclosed. Each system includes an instrument, a control valve and, optionally, a suction controller. The instrument is in the form of an elongated, flexible member having a distal end portion arranged for anchoring the instrument in the patient's stomach and for enabling fluids to be removed from the patient's stomach. Suction is applied to the patient's stomach by the distal end portion of the instrument to drain gastric fluids and to bring adjacent portions of the patient's stomach into engagement with the instrument to provide a visually perceptible delineation line along which a portion of the stomach may be resected, sealed and tested.

Abstract: Disclosed herein are nucleic acid molecules encoding a Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) spike antigen, SARS-CoV-2 spike antigens, immunogenic compositions, and vaccines and their use in inducing immune responses and protecting against or treating a SARS-CoV-2 infection in a subject.

Abstract: Disclosed herein are methods of administering and uses of a plasmid encoding residues 19-1279 of SEQ ID NO: 1, a plasmid comprising nucleotides 55-3837 of SEQ ID NO: 2, pGX9501, INO-4800 drug product, or a biosimilar thereof to induce an immune response against Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) variant B.1.351, SARS-CoV-2 variant B.1.1.7, SARS-CoV-2 variant P.1, SARS-CoV-2 variant B.1.617.1, SARS-CoV-2 variant B.1.617.2, or SARS-CoV-2 variant B.1.1.529.

Abstract: A wireless power initiated test system can use an aircraft controller to automatically initiate a test sequence to determine status of systems of the aircraft, based on the detection of receipt of the wireless power at the aircraft. The detection of receipt of the wireless power at the aircraft can be based on the detection at a voltage regulator of the aircraft which is receiving the wireless power from a wireless power receiver of the aircraft. The system may also power the aircraft controller during the test sequence using the wireless power received. Such a system may quickly and efficiently initiate, power and perform a pre-flight test sequence to determine statuses of systems of the aircraft, such as during a competition or race of the aircraft. The system may apply to drones, as well as of other types of aircraft.

Abstract: Techniques are described for the exchange of control signals between a controlled unmanned aircraft (i.e. drone) and a ground control station and for the transmission of communication signals, such as video, from the drone to the ground control station so that the signals are more difficult to intercept or jam. The video signal transmitted from the drone can be an analog RF signal employing one or more of video “scrambling”, RF signal inversion, hopping, usage of a wide frequency range and other techniques. To secure the control signals between the drone and the ground control station, techniques can include hopping, encryption and use of a wide frequency range.

Abstract: A heater system includes a heater bundle. The heater bundle includes at least one heater assembly, where the heater assembly includes a plurality of heater units, and more than one of the heater units defines at least one independently controlled heating zone. The heater bundle includes a plurality of power conductors electrically connected to the independently controlled heating zone. The heater system includes means for determining temperature and at least one power switch, the power switch disposed proximate the heater bundle. The heater system includes at least one controller configured to modulate power to the independently controlled heating zones through the power conductors based on the determined temperature to provide a desired power output along a length of the heater assembly. The controller is configured to provide power to the power switch.

Abstract: Systems and methods for effecting bariatric procedures are disclosed. Each system includes an instrument, a control valve and, optionally, a suction controller. The instrument is in the form of an elongated, flexible sizing tube having a distal end portion including a plurality of apertures. The control valve enables suction to be applied to the patient's stomach via the apertures to drain gastric fluids and to bring adjacent portions of the patient's stomach into engagement with the sizing tube to provide a visually perceptible delineation line along which a portion of the stomach may be resected, sealed and tested.

Abstract: Systems and methods for effecting bariatric procedures are disclosed. Each system includes an instrument, a control valve and, optionally, a suction controller. The instrument is in the form of an elongated, flexible sizing tube having a distal end portion including a plurality of apertures. The control valve enables suction to be applied to the patient's stomach via the apertures to drain gastric fluids and to bring adjacent portions of the patient's stomach into engagement the sizing tube to provide a visually perceptible delineation line along which a portion of the stomach may be resected, sealed and tested.