Abstract: Disclosed herein is a composition including a recombinant nucleic acid sequence that encodes an antibody to a Respiratory Syncytial Virus antigen. Also disclosed herein is a method of generating a synthetic antibody in a subject by administering the composition to the subject. The disclosure also provides a method of preventing and/or treating an Respiratory Syncytial virus infection in a subject using the composition and method of generation.

Abstract: A step path for an exercise device includes a support zone, a return zone, and a transition zone between the support zone and the return zone. In the support zone, a front end of a movable step is supported by a front track guide and a rear end of the movable step is supported by a rear track guide. A transition element supports the rear end of the step between the rear guide track and a base guide track, thereby lowering the step-up height of the exercise device.

Abstract: A heater system includes a heater bundle. The heater bundle includes at least one heater assembly, where the heater assembly includes a plurality of heater units, and more than one of the heater units defines at least one independently controlled heating zone. The heater bundle includes a plurality of power conductors electrically connected to the independently controlled heating zone. The heater system includes means for determining temperature and at least one power switch, the power switch disposed proximate the heater bundle. The heater system includes at least one controller configured to modulate power to the independently controlled heating zones through the power conductors based on the determined temperature to provide a desired power output along a length of the heater assembly. The controller is configured to provide power to the power switch.

Abstract: A device and method for removing by suction urine voided by a patient. The device includes an impermealble bag, a wicking pad, a spacer, and an adhesive patch. The bag includes an internal chamber and an entryway through which the penis of the patient is inserted. The wicking pad has a first portion located within the chamber and a second portion located outside the bag in communication with the ambient atmosphere. The adhesive patch secures the device to the patient. The bag includes a port at which regulated suction is provided to carry urine from the patient through the first portion of the wicking pad and out the port. Ambient air flows into the second portion to facilitate the flow of urine therethrough and to aid in drying the wicking pad. The spacer is located outside the bag for enhancing air flow through the second portion.

Abstract: Example methods, compositions and structures are presented whereby sub-10-nm-thick strain-relieving Si1-xGex layers can be realized by Ge ion implantation, into, and selective oxidation of, Si(111) wafers. The resulting Ge-rich layers are fully strain relaxed via a network of misfit dislocations at the Si/Si1-xGe, interface, which do not propagate through the Si1-xGex film. The dislocation network has been found to coincide with a periodic variation in the composition at the Si/Si1-xGex interface and is believed to result from the defect-medicated diffusion of Si atoms from the Si substrate through the Si1-xGex layer to the above SiO2 layer. The epitaxial growth of GaAs on such ultra-thin substrates is demonstrated, presenting a promising approach for solving the long-standing challenge of local, monolithic integration of III-V optoelectronics on the Si platform.

Abstract: A device and method of use for preventing or treating postpartum uterine bleeding or hemorrhage of a patient. The device includes a suction tube having a distal end portion at which an aperture or an array of plural apertures is located and extending about the periphery of the distal portion. A sealing member having an apex and flexible sidewall is mounted on the suction tube so that a portion of its sidewall can be brought into engagement with tissue of the uterus. Suction from a vacuum source is applied to a proximal end portion of the suction tube to apply suction via the aperture(s) to the interior of the patient's uterus. The suction tube may include an illumination system for illuminating the interior of the patient's vagina.

Abstract: A step path for an exercise device includes a support zone, a return zone, and a transition zone between the support zone and the return zone. In the support zone, a front end of a movable step is supported by a front track guide and a rear end of the movable step is supported by a rear track guide. A transition element supports the rear end of the step between the rear guide track and a base guide track, thereby lowering the step-up height of the exercise device.

Abstract: Systems and methods for effecting bariatric procedures are disclosed. Each system includes an instrument, a control valve and, optionally, a suction controller. The instrument is in the form of an elongated, flexible sizing tube having a distal end portion including a plurality of apertures. The control valve enables suction to be applied to the patient's stomach via the apertures to drain gastric fluids and to bring adjacent portions of the patient's stomach into engagement the sizing tube to provide a visually perceptible delineation line along which a portion of the stomach may be resected, sealed and tested.

Abstract: Systems for visualization and management of a clinical study have a processor, an input device, a database storing data related to the clinical study, and a visit schedule interface. The data have a study visit schedule. The study visit schedule has nodes and a track having a step sequence. Each node has a node position and node attributes. The node position has a node track identifying the track and a node step. The data may also have a visit travel policy and the node attributes may have a visit policy label associated with the visit travel policy.

Abstract: A system for visualization and management of participants in studies having a graphical user interface (GUI), a database (DB) storing studies data, visit schedules, travel policies, sites data, and participants data having a first participant in a first study. The GUI has controls including system control, data controls (being one or more of a travel policy control, visit schedule control, and participant control), navigation control associated with the study, and selection control associated with the participant. The GUI responsive to using the controls can a) switch GUI views; b) receive and display participants data; c) receive and display visit schedule and travel policy associated with the first participant and with the first study; d) receive input data from the input device and cause the DB to update the studies data, participants data, travel policies, and visit schedules with the input data. DB may store a second participant.

Abstract: Systems for visualization and management of a study have an input device, a user interface, controls, and a database storing a visit schedule about the study and visit data about a participant. Visit schedule has a first node and second node. The participant visit data has a current visit associated with the first node. The user interface visually associates the first node with a first graphic and with a current visual attribute, and the second node with a second graphic. Responsive to the controls, the user interface associates the second node with the current visit and visually associates the current node graphic with the second node. Visit schedule may have a third node selected from a jump, cycle, exit, and other nodes. The third node is associated with an occurred visit in the visit data, and the user interface can visually associate an occurred visual attribute with the third node.

Abstract: Disclosed herein are antibodies to SARS-COV-2 antigens and recombinant nucleic acid sequences that encode the SARS-COV-2 antibodies. The disclosure also provides a method of preventing and/or treating a SARS-COV-2 infection or disease or disorder associated with SARS-COV-2 infection (e.g., COVID-19) in a subject using said compositions and methods.

Abstract: Disclosed herein are nucleic acid encoded Fc-modified antibodies and methods of use of the same for the treatment of diseases and disorders.

Abstract: A privacy enabled system for managing clinical study participant travel has a database (stores data: clinical study, participant, clinical site and trip data sets) and a graphical user interface that has a Travel Planning Interface and is in data communication with an input device and the database. The data sets include a Study Travel Policy, a Study Visit Schedule (appointment procedure, appointment schedule), a traveler profile, traveler personal data (traveler contact information), a site appointment location associated with the appointment procedure, and site contact information. The travel planning interface receives the trip data set (trip segment data) from the database and the input device. The travel planning interface transmits the trip segment data to and receives booked travel data from a travel booking module, generates an itinerary that has booked travel and trip segment data, and transmits the itinerary according to the traveler contact information and the site contact information.

Abstract: Systems for visualization and management of a travel policy for a clinical study have a study dataset having a first travel policy condition, a study travel policy dataset having a main travel policy and a specialized travel policy, and a GUI having a travel policies interface and a travel policy control. The first travel policy condition may be a country, a clinical site, a traveler policy label, a visit attribute, a visit policy label, and combinations thereof. The specialized travel policy (a country policy, a site policy, a first visit policy, a second visit policy, a custom policy, and combinations thereof) is programmatically associated with the first travel policy condition.

Abstract: A privacy enabled system for managing clinical study participant travel has a database (stores data: clinical study, participant, clinical site and trip data sets) and a graphical user interface that has a Travel Planning Interface and is in data communication with an input device and the database. The data sets include a Study Travel Policy, a Study Visit Schedule (appointment procedure, appointment schedule), a traveler profile, traveler personal data (traveler contact information), a site appointment location associated with the appointment procedure, and site contact information. The travel planning interface receives the trip data set (trip segment data) from the database and the input device. The travel planning interface transmits the trip segment data to and receives booked travel data from a travel booking module, generates an itinerary that has booked travel and trip segment data, and transmits the itinerary according to the traveler contact information and the site contact information.

Abstract: Systems for visualization and management of a travel policy for a clinical study have a study dataset having a first travel policy condition, a study travel policy dataset having a main travel policy and a specialized travel policy, and a GUI having a travel policies interface and a travel policy control. The first travel policy condition may be a country, a clinical site, a traveler policy label, a visit attribute, a visit policy label, and combinations thereof. The specialized travel policy (a country policy, a site policy, a first visit policy, a second visit policy, a custom policy, and combinations thereof) is programmatically associated with the first travel policy condition.

Abstract: Systems and methods for effecting bariatric procedures are disclosed. Each system includes an instrument, a control valve and, optionally, a suction controller. The instrument is in the form of an elongated, flexible sizing tube having a distal end portion including a plurality of apertures. The control valve enables suction to be applied to the patient's stomach via the apertures to drain gastric fluids and to bring adjacent portions of the patient's stomach into engagement with the sizing tube to provide a visually perceptible delineation line along which a portion of the stomach may be resected, sealed and tested.

Abstract: This present invention provides means for cell harvesting and isolation to be carried out with a single apparatus. This represents a more convenient way for the processing of cells compared with known methods and represents a useful development for the manufacture of cell therapies.

Abstract: Systems and methods for effecting bariatric procedures are disclosed. Each system includes an instrument, a control valve and, optionally, a suction controller. The instrument is in the form of an elongated, flexible sizing tube having a distal end portion including a plurality of apertures. The control valve enables suction to be applied to the patient's stomach via the apertures to drain gastric fluids and to bring adjacent portions of the patient's stomach into engagement with the sizing tube to provide a visually perceptible delineation line along which a portion of the stomach may be resected, sealed and tested.