Abstract: A privacy enabled system for managing clinical study participant travel has a database (stores data: clinical study, participant, clinical site and trip data sets) and a graphical user interface that has a Travel Planning Interface and is in data communication with an input device and the database. The data sets include a Study Travel Policy, a Study Visit Schedule (appointment procedure, appointment schedule), a traveler profile, traveler personal data (traveler contact information), a site appointment location associated with the appointment procedure, and site contact information. The travel planning interface receives the trip data set (trip segment data) from the database and the input device. The travel planning interface transmits the trip segment data to and receives booked travel data from a travel booking module, generates an itinerary that has booked travel and trip segment data, and transmits the itinerary according to the traveler contact information and the site contact information.

Abstract: Systems for visualization and management of a travel policy for a clinical study have a study dataset having a first travel policy condition, a study travel policy dataset having a main travel policy and a specialized travel policy, and a GUI having a travel policies interface and a travel policy control. The first travel policy condition may be a country, a clinical site, a traveler policy label, a visit attribute, a visit policy label, and combinations thereof. The specialized travel policy (a country policy, a site policy, a first visit policy, a second visit policy, a custom policy, and combinations thereof) is programmatically associated with the first travel policy condition.

Abstract: Systems and methods for generating blood flow with a blood pump including a membrane and an encapsulated actuator are described. The pump may be implantable and may include a stator assembly, an electromagnetic assembly supported by the stator assembly, a magnetic assembly, one or more springs attached to the stator and the magnetic assembly, and encapsulation portions that connect the magnetic assembly to the stator assembly. The magnetic assembly may further be coupled to a membrane assembly including a flexible membrane. The electromagnetic assembly may be selectively activated to cause the magnetic assembly to reciprocate, thereby causing the membrane assembly to reciprocate and inducing wavelike undulations in the flexible membrane to pump blood from an inlet to an outlet of the pump. The encapsulation portions may prevent blood from interacting with an interior moving portion of the pump thereby reducing the risk of hemolysis.

Abstract: An electrical connector includes a plug that mates with a receptacle. In a medical application, the plug is connected to electrical leads that pass through a patient's skin to an implanted medical device in the patient's body, while the receptacle is connected to external medical equipment. All electrical contacts in the plug are on internal portions. The receptacle includes annular contacts that contact the internal electrical contacts on the plug when the plug and receptacle are properly mated. The receptacle includes a plurality of annular electrical contacts that have a first diameter and are separated by a plurality of annular insulators having a second diameter smaller than the first diameter.

Abstract: Systems and methods for generating blood flow with a pump incorporating linear bearing technology are provided. The pump may include an actuator assembly, a moving assembly, and a linear hydrodynamic or thin-film bearing positioned within a housing. The moving assembly may include at least one magnet and the actuator assembly may include a magnetic assembly for selectively generating a magnetic field to cause linear reciprocating movement of the moving assembly with respect to the actuator assembly. The linear hydrodynamic or thin-film bearing may include a bearing portion on the moving assembly that is in fluid communication with a bearing portion on the actuator assembly or pump housing. The system may involve an implantable pump, an extracorporeal battery and a controller coupled to the implantable pump. The implantable pump may be suitable for use as a left ventricular assist device (LVAD).

Abstract: Systems and methods for generating blood flow with a pump incorporating linear bearing technology are provided. The pump may include an actuator assembly, a moving assembly, and a linear hydrodynamic or thin-film bearing positioned within a housing. The moving assembly may include at least one magnet and the actuator assembly may include a magnetic assembly for selectively generating a magnetic field to cause linear reciprocating movement of the moving assembly with respect to the actuator assembly. The linear hydrodynamic or thin-film bearing may include a bearing portion on the moving assembly that is in fluid communication with a bearing portion on the actuator assembly or pump housing. The system may involve an implantable pump, an extracorporeal battery and a controller coupled to the implantable pump. The implantable pump may be suitable for use as a left ventricular assist device (LVAD).

Abstract: An electrical connector includes a plug that mates with a receptacle. In a medical application, the plug is connected to electrical leads that pass through a patient's skin to an implanted medical device in the patient's body, while the receptacle is connected to external medical equipment. All electrical contacts in the plug are on internal portions. The receptacle includes annular contacts that contact the internal electrical contacts on the plug when the plug and receptacle are properly mated. The receptacle includes a plurality of annular electrical contacts that have a first diameter and are separated by a plurality of annular insulators having a second diameter smaller than the first diameter.

Abstract: An electrical connector includes a plug that mates with a receptacle. In a medical application, the plug is connected to electrical leads that pass through a patient's skin to an implanted medical device in the patient's body, while the receptacle is connected to external medical equipment. The plug is small in diameter so the size of the opening in the patient's skin can be minimized. All electrical contacts in the plug are on internal portions. The receptacle includes annular contacts that contact the internal electrical contacts on the plug when the plug and receptacle are properly mated. When the plug is plugged into the receptacle, spring-loaded retention arms in the receptacle lock into place on the plug, retaining the plug in the receptacle.

Abstract: An electrical connector includes a plug that mates with a receptacle. In a medical application, the plug is connected to electrical leads that pass through a patient's skin to an implanted medical device in the patient's body, while the receptacle is connected to external medical equipment. The plug is small in diameter so the size of the opening in the patient's skin can be minimized. All electrical contacts in the plug are on internal portions. The receptacle includes annular contacts that contact the internal electrical contacts on the plug when the plug and receptacle are properly mated. When the plug is plugged into the receptacle, spring-loaded retention arms in the receptacle lock into place on the plug, retaining the plug in the receptacle.

Abstract: An electrical connector includes a plug that mates with a receptacle. In a medical application, the plug is connected to electrical leads that pass through a patient's skin to an implanted medical device in the patient's body, while the receptacle is connected to external medical equipment. All electrical contacts in the plug are on internal portions. The receptacle includes annular contacts that contact the internal electrical contacts on the plug when the plug and receptacle are properly mated. The receptacle includes a plurality of annular electrical contacts that have a first diameter and are separated by a plurality of annular insulators having a second diameter smaller than the first diameter.

Abstract: An electrical connector includes a plug that mates with a receptacle. In a medical application, the plug is connected to electrical leads that pass through a patient's skin to an implanted medical device in the patient's body, while the receptacle is connected to external medical equipment. The plug is small in diameter so the size of the opening in the patient's skin can be minimized. All electrical contacts in the plug are on internal portions. The receptacle includes annular contacts that contact the internal electrical contacts on the plug when the plug and receptacle are properly mated. When the plug is plugged into the receptacle, spring-loaded retention arms in the receptacle lock into place on the plug, retaining the plug in the receptacle.

Abstract: An electrical connector includes a plug that mates with a receptacle. In a medical application, the plug is connected to electrical leads that pass through a patient's skin to an implanted medical device in the patient's body, while the receptacle is connected to external medical equipment. The plug is small in diameter so the size of the opening in the patient's skin can be minimized. All electrical contacts in the plug are on internal portions. The receptacle includes annular contacts that contact the internal electrical contacts on the plug when the plug and receptacle are properly mated. When the plug is plugged into the receptacle, spring-loaded retention arms in the receptacle lock into place on the plug, retaining the plug in the receptacle.

Abstract: An electrical connector includes a plug that mates with a receptacle. In a medical application, the plug is connected to electrical leads that pass through a patient's skin to an implanted medical device in the patient's body, while the receptacle is connected to external medical equipment. The plug is small in diameter so the size of the opening in the patient's skin can be minimized. All electrical contacts in the plug are on internal portions. The receptacle includes spring-loaded contacts that contact the internal electrical contacts on the plug when the plug and receptacle are properly mated. When the plug is plugged into the receptacle, spring-loaded retention arms in the receptacle lock into place on the plug, retaining the plug in the receptacle.

Abstract: An electrical connector includes a plug that mates with a receptacle. In a medical application, the plug is connected to electrical leads that pass through a patient's skin to an implanted medical device in the patient's body, while the receptacle is connected to external medical equipment. The plug is small in diameter so the size of the opening in the patient's skin can be minimized. All electrical contacts in the plug are on internal portions. The receptacle includes spring-loaded contacts that contact the internal electrical contacts on the plug when the plug and receptacle are properly mated. When the plug is plugged into the receptacle, spring-loaded retention arms in the receptacle lock into place on the plug, retaining the plug in the receptacle.

Abstract: An electrical connector includes a plug that mates with a receptacle. In a medical application, the plug is connected to electrical leads that pass through a patient's skin to an implanted medical device in the patient's body, while the receptacle is connected to external medical equipment. All electrical contacts in the plug are on internal portions. The receptacle includes annular contacts that contact the internal electrical contacts on the plug when the plug and receptacle are properly mated. The receptacle includes a plurality of annular electrical contacts that have a first diameter and are separated by a plurality of annular insulators having a second diameter smaller than the first diameter.

Abstract: An electrical connector includes a plug that mates with a receptacle. In a medical application, the plug is connected to electrical leads that pass through a patient's skin to an implanted medical device in the patient's body, while the receptacle is connected to external medical equipment. The plug is small in diameter so the size of the opening in the patient's skin can be minimized. All electrical contacts in the plug are on internal portions. The receptacle includes annular contacts that contact the internal electrical contacts on the plug when the plug and receptacle are properly mated. When the plug is plugged into the receptacle, spring-loaded retention arms in the receptacle lock into place on the plug, retaining the plug in the receptacle.

Abstract: In one aspect, methods of printing a 3D article are described herein. In some embodiments, a method of printing a 3D article comprises selectively depositing a first portion of build material in a fluid state onto a substrate to form a first region of build material; selectively depositing a first portion of support material in a fluid state to form a first region of support material; and selectively depositing a second portion of build material in a fluid state to form a second region of build material, wherein the first region of support material is disposed between the first region of build material and the second region of build material in a z-direction of the article. In some cases, the first region of support material forms a grayscale pattern and/or a CMY color pattern in combination with the first region of build material and/or the second region of build material.

Abstract: In one aspect, methods of printing a 3D article are described herein. In some embodiments, a method of printing a 3D article comprises selectively depositing a first portion of build material in a fluid state onto a substrate to form a first region of build material; selectively depositing a first portion of support material in a fluid state to form a first region of support material; and selectively depositing a second portion of build material in a fluid state to form a second region of build material, wherein the first region of support material is disposed between the first region of build material and the second region of build material in a z-direction of the article. In some cases, the first region of support material forms a grayscale pattern and/or a CMY color pattern in combination with the first region of build material and/or the second region of build material.

Abstract: In one aspect, methods of printing a 3D article are described herein. In some embodiments, a method of printing a 3D article comprises selectively depositing a first portion of build material in a fluid state onto a substrate to form a first region of build material; selectively depositing a first portion of support material in a fluid state to form a first region of support material; and selectively depositing a second portion of build material in a fluid state to form a second region of build material, wherein the first region of support material is disposed between the first region of build material and the second region of build material in a z-direction of the article. In some cases, the first region of support material forms a grayscale pattern and/or a CMY color pattern in combination with the first region of build material and/or the second region of build material.

Abstract: The present application is drawn to a synthetic, polymer hydrogel-based material, which is able to actively induce the body's natural hemostatic coagulation process in blood or acellular plasma. The present invention provides the development of a primary amine containing polymer hydrogel capable of inducing blood coagulation and delivering therapeutics for hemostatic or wound care applications, and a method of forming such a primary amine containing polymer hydrogel capable of inducing the blood coagulation process. The primary amine containing polymer hydrogel is able to achieve the same end result as biological-based hemostatics, without the innate risk of disease transmission or immunological response, and at a fraction of the price. Furthermore, due to its inherent hydrogel-based design the material has the capability of arresting blood loss while simultaneously delivering therapeutics in a controlled manner, potentially revolutionizing the way in which wounds are treated.