Abstract: The invention provides a method for assigning a cellular function to a component of a biochemical system. The method involves (a) determining a multidimensional shape space for one or more components of a biochemical system in a reference state; (b) perturbing a component within said biochemical system; (c) determining a perturbed multidimensional shape space for one or more components of a pathway in said perturbed biochemical system, and (d) identifying a multidimensional coordinate point corresponding to a component of said perturbed pathway altered between reference and perturbed multidimensional shape spaces, said identified component being assigned a cellular function of said perturbed pathway.

Abstract: The invention provides a method for assigning a cellular function to a component of a biochemical system. The method involves (a) determining a multidimensional shape space for one or more components of a biochemical system in a reference state; (b) perturbing a component within said biochemical system; (c) determining a perturbed multidimensional shape space for one or more components of a pathway in said perturbed biochemical system, and (d) identifying a multidimensional coordinate point corresponding to a component of said perturbed pathway altered between reference and perturbed multidimensional shape spaces, said identified component being assigned a cellular function of said perturbed pathway.

Abstract: The invention provides methods of predicting a behavior of a biochemical system. In one embodiment, the method consists of comparing two or more data integration maps of a biochemical system obtained under different conditions, the data integration map comprising at least two networks, and identifying correlative changes in at least two value sets between said two or more data integration maps with different conditions, wherein the correlative changes predict a behavior of the biochemical system.

Abstract: The invention relates to a method of determining a true signal of an analyte, comprising (a) measuring an observed signal x for one or more analytes, and (b) determining a mean signal (&mgr;) and a system parameter (&bgr;) for said analyte that produce enhanced values for a probability likelihood of said observed signal, said observed signal being related to said mean signal by an additive error (&dgr;) and a multiplicative error (&egr;), wherein said system parameter specifies properties of said additive error (&dgr;) and said multiplicative error (&egr;).