Patents by Inventor Tri B Huynh

Tri B Huynh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of tetravalent antibodies
    Patent number: 6897044
    Abstract: The present invention relates to a novel process for the preparation of biologically active antibody dimers in a pharmaceutically acceptable composition. The dimers can be composed of two antibody molecules having the same antigen binding specificity and linked through reducible, disulfide, or a non-reducible thioether, bond (homodimer). Alternatively, the dimers can be composed of two different antibody molecules having binding specificity for two distinct antigens (heterodimer). These dimers are useful for inducing hyper-cross-linking of membrane antigens. The present invention further relates to the use of biologically active antibody dimers for the preferential killing or inhibition of selected cell populations in the treatment of diseases such as cancer and autoimmune disorders.
    Type: Grant
    Filed: January 28, 1999
    Date of Patent: May 24, 2005
    Assignee: Biogen Idec, Inc.
    Inventors: Gary R Braslawsky, Nabil Hanna, Kandasamy Hariharan, Michael J LaBarre, Tri B Huynh