Patents by Inventor Tricia Cecil

Tricia Cecil has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microspheres and adjuvants for DNA vaccine delivery
    Publication number: 20040009941
    Abstract: A nucleic acid delivery system that offers, in one system, a combination of high encapsulation efficiency, rapid release kinetics and preservation of DNA in supercoiled form is provided. The nucleic acid delivery system comprises nucleic acid molecules, such as deoxyribonucleic acid (DNA), encapsulated in biodegradable microspheres, and is particularly suited for delivery of DNA vaccines. The invention further provides a method for encapsulating nucleic acid molecules in microspheres. The invention additionally provides a composition comprising nucleic acid molecules encapsulated in microspheres produced by a method of the invention, and a method for delivering a nucleic acid molecule to a subject. The invention further provides an adjuvant for modulating the immunostimulatory efficacy of microspheres encapsulating nucleic acid molecules comprising an aminoalkyl glucosaminide 4-phosphate (AGP).
    Type: Application
    Filed: April 22, 2003
    Publication date: January 15, 2004
    Applicant: Corixa Corporation
    Inventors: Mark E. Johnson, Sally Mossman, Tricia Cecil, Lawrence Evans
  • Microsphere delivery of mucin peptides
    Publication number: 20020142047
    Abstract: A mucin peptide, such as MUC-1, encapsulated in a biodegradable polymeric microsphere is disclosed. The encapsulated mucin peptide breaks tolerance of helper T cells as it elicits a stronger immune response and provides improved protection against tumor challenge than direct administration of peptide, alone or with an adjuvant. The encapsulated mucin peptide can be used in a vaccine composition, and can be used in a method for delivering a mucin peptide to a subject, as well as in a method treating or preventing a cancer associated with reduced glycosylation of MUC-1.
    Type: Application
    Filed: January 22, 2002
    Publication date: October 3, 2002
    Inventors: Mark E. Johnson, Tricia Cecil, Olivera J. Finn
  • Microspheres and adjuvants for DNA vaccine delivery
    Publication number: 20020032165
    Abstract: A nucleic acid delivery system that offers, in one system, a combination of high encapsulation efficiency, rapid release kinetics and preservation of DNA in supercoiled form is provided. The nucleic acid delivery system comprises nucleic acid molecules, such as deoxyribonucleic acid (DNA), encapsulated in biodegradable microspheres, and is particularly suited for delivery of DNA vaccines. The invention further provides a method for encapsulating nucleic acid molecules in microspheres. The invention additionally provides a composition comprising nucleic acid molecules encapsulated in microspheres produced by a method of the invention, and a method for delivering a nucleic acid molecule to a subject. The invention further provides an adjuvant for modulating the immunostimulatory efficacy of microsphetes encapsulating nucleic acid molecules comprising an aminoalkyl glucosanide 4-phosphate (AGP).
    Type: Application
    Filed: July 9, 2001
    Publication date: March 14, 2002
    Inventors: Mark E. Johnson, Sally Mossman, Tricia Cecil, Lawrence Evans