Patents by Inventor Tricia Cregger
Tricia Cregger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10823715Abstract: This invention relates to a chemical indicator for monitoring a vaporous hydrogen peroxide sterilization process. The chemical indicator comprises a reactive composition adhered to a substrate, the reactive composition comprising a transition metal reagent, an oxidizing agent, and a resin. A test pack containing the chemical indicator and a biological indicator is disclosed. Vaporous hydrogen peroxide sterilization processes using the chemical indicator and the test pack are disclosed.Type: GrantFiled: July 19, 2017Date of Patent: November 3, 2020Assignee: American Sterilizer CompanyInventors: Tricia Cregger, Phillip F. Franciskovich
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Patent number: 10301632Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: GrantFiled: June 6, 2018Date of Patent: May 28, 2019Assignee: American Sterilizer CompanyInventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Patent number: 10301631Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: GrantFiled: June 6, 2018Date of Patent: May 28, 2019Assignee: American Sterilizer CompanyInventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Publication number: 20190106726Abstract: This invention relates to a biological indicator, comprising: a carrier; and a spore deposit on the carrier, wherein at least about 95% of the area of the spore deposit comprises spores residing in a single spore layer.Type: ApplicationFiled: October 11, 2017Publication date: April 11, 2019Inventors: Tricia Cregger, William Yirava, Phillip Franciskovich, Kathleen A. Fix
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Publication number: 20190106725Abstract: This invention relates to a biological indicator, comprising: a carrier; and a spore deposit on the carrier, wherein from about 70% to about 95% of the area of the spore deposit comprises spores residing in a single spore layer, and the remainder of the area of the spore deposit comprises spores residing in a stacked configuration.Type: ApplicationFiled: October 11, 2017Publication date: April 11, 2019Inventors: Tricia Cregger, William Yirava, Phillip Franciskovich, Kathleen A. Fix
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Publication number: 20190025268Abstract: This invention relates to a chemical indicator for monitoring a vaporous hydrogen peroxide sterilization process. The chemical indicator comprises a reactive composition adhered to a substrate, the reactive composition comprising a transition metal reagent, an oxidizing agent, and a resin. A test pack containing the chemical indicator and a biological indicator is disclosed. Vaporous hydrogen peroxide sterilization processes using the chemical indicator and the test pack are disclosed.Type: ApplicationFiled: July 19, 2017Publication date: January 24, 2019Inventors: Tricia Cregger, Phillip F. Franciskovich
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Publication number: 20180273957Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: ApplicationFiled: June 6, 2018Publication date: September 27, 2018Inventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Publication number: 20180273958Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: ApplicationFiled: June 6, 2018Publication date: September 27, 2018Inventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Patent number: 10017772Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: GrantFiled: June 9, 2017Date of Patent: July 10, 2018Assignee: American Sterilizer CompanyInventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Publication number: 20180187143Abstract: This invention relates to a biological indicator, comprising: a carrier inoculated with a test organism and an effective amount of a carbohydrate to reduce the resistance of the biological indicator to steam sterilization. The invention relates to a steam sterilization process using the biological indicator.Type: ApplicationFiled: March 1, 2018Publication date: July 5, 2018Inventors: William A. Yirava, Nicole M. Beahn, Phillip Franciskovich, Tricia Cregger
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Patent number: 10011843Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: GrantFiled: June 9, 2017Date of Patent: July 3, 2018Assignee: American Sterilizer CompanyInventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Patent number: 10011844Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: GrantFiled: June 9, 2017Date of Patent: July 3, 2018Assignee: American Sterilizer CompanyInventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Publication number: 20170275631Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: ApplicationFiled: June 9, 2017Publication date: September 28, 2017Inventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Publication number: 20170275633Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: ApplicationFiled: June 9, 2017Publication date: September 28, 2017Inventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Publication number: 20170275632Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: ApplicationFiled: June 9, 2017Publication date: September 28, 2017Inventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Publication number: 20170211035Abstract: This invention relates to a biological indicator, comprising: a carrier inoculated with a test organism and an effective amount of a carbohydrate to reduce the resistance of the biological indicator to steam sterilization. The invention relates to a steam sterilization process using the biological indicator.Type: ApplicationFiled: January 25, 2016Publication date: July 27, 2017Inventors: William A. Yirava, Nicole M. Beahn, Phillip Franciskovich, Tricia Cregger
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Patent number: 9701968Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: GrantFiled: July 7, 2016Date of Patent: July 11, 2017Assignee: American Sterilizer CompanyInventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Patent number: 9695428Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: GrantFiled: July 7, 2016Date of Patent: July 4, 2017Assignee: American Sterilizer CompanyInventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Publication number: 20160312232Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: ApplicationFiled: July 7, 2016Publication date: October 27, 2016Inventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke
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Publication number: 20160312263Abstract: This invention relates to a biological indicator derived from a composition comprising: a host organism comprising a spore forming bacteria; a reporter gene for producing an indicator enzyme; a regulatory gene; and a vehicle for inserting the reporter gene and the regulatory gene in the host organism; the host organism bearing a transposable genetic element in its genome for inserting an insertion sequence in the regulatory gene; the insertion sequence comprising a transposase, a pair of terminal inverted repeat sequences, and at least one open reading frame for expressing the transposase. The vehicle may be taken up by the host organism. The insertion sequence may be inserted in the regulatory gene. The host organism may undergo sporulation to form the biological indicator. A process and an apparatus for using the biological indicator are disclosed.Type: ApplicationFiled: July 7, 2016Publication date: October 27, 2016Inventors: Phillip P. Franciskovich, Tricia A. Cregger, William A. Yirava, Peter A. Burke