Abstract: Provided are multilayer structures that include a first layer and a second layer, in which the first layer consists essentially of a machine direction oriented high density polyethylene film (MDO HDPE) and the second layer includes a heat seal layer. Typically, the MDO HDPE has a weight average molecular weight less than about 500,000 g/mol, a number average molecular weight less than about 500,000 g/mol, a moisture vapor transmission rate (MVTR) of greater than about 0.30 g/100SI/day/mil, or a combination of two more thereof. The structures may further include other layers such as adhesive, print, and/or oxygen barrier layers.