Abstract: The subject invention provides methods of treating neurological disease or disorder, such as brain injuries, such as stroke, traumatic brain injury (TBI), or other ischemic events that cause brain injury by inhibiting or down-regulating Let-7i activity or function. The disclosed methods may have the potential to extend the “window of opportunity” for treatment of such injuries and enhance the effectiveness of existing therapeutics.

Abstract: A storage controller receives a command to delete a dataset stored in a first set of storage volumes controlled by the storage controller. In response to receiving the command, a determination is made as to whether an indicator has been enabled to protect the dataset against an accidental deletion. In response to determining that the indicator has been enabled, the dataset is copied from the first set of storage volumes to a second set of storage volumes controlled by the storage controller. In response to completion of the copying of the dataset from the first set of storage volumes to the second set of storage volumes, the command to delete the dataset stored in the first set of storage volumes is executed.

Abstract: A storage controller receives a command to delete a dataset stored in a first set of storage volumes controlled by the storage controller. In response to receiving the command, a determination is made as to whether an indicator has been enabled to protect the dataset against an accidental deletion. In response to determining that the indicator has been enabled, the dataset is copied from the first set of storage volumes to a second set of storage volumes controlled by the storage controller. In response to completion of the copying of the dataset from the first set of storage volumes to the second set of storage volumes, the command to delete the dataset stored in the first set of storage volumes is executed.

Abstract: Apparatus and methods for managing, manipulating and presenting data objects within a graphical user interface with variable dimensions, shapes, locations and interactions. The apparatus and methods allow for variable data objects to be both pinned and liquid depending on a larger management and manipulation apparatus. The apparatus consists of databases that store the data objects to be displayed within the user interface and the layout coordinates, variable potential object size, and whether the object can move or not based on the graphical user interface dimensions. The object manipulations include the representation of such objects on the graphical user interface in a defined sequence.

Abstract: The present invention provides for giving preference to a specific media gateway in the selection of the next circuit so that in a multi-media-gateway soft-switch where a call may take any of many possible paths, an outgoing circuit on the same media-gateway as the incoming circuit is preferably selected, so if one is available, the need for using more bearer ports on media gateways to bridge the two sides is eliminated. Instead of interconnection, the same facilities can be provisioned to the bearer interface between the soft-switch and the rest of the network. This invention maximizes the bearer capacity of a distributed media gateway for external network access.

Abstract: Apparatus and methods for managing, manipulating and presenting data objects within a graphical user interface with variable dimensions, shapes, locations and interactions. The apparatus and methods allow for variable data objects to be both pinned and liquid depending on a larger management and manipulation apparatus. The apparatus consists of databases that store the data objects to be displayed within the user interface and the layout coordinates, variable potential object size, and whether the object can move or not based on the graphical user interface dimensions. The object manipulations include the representation of such objects on the graphical user interface in a defined sequence.

Abstract: The present invention provides for giving preference to a specific media gateway in the selection of the next circuit so that in a multi-media-gateway soft-switch where a call may take any of many possible paths, an outgoing circuit on the same media-gateway as the incoming circuit is preferably selected, so if one is available, the need for using more bearer ports on media gateways to bridge the two sides is eliminated. Instead of interconnection, the same facilities can be provisioned to the bearer interface between the soft-switch and the rest of the network. This invention maximizes the bearer capacity of a distributed media gateway for external network access.

Abstract: A data processor includes a first bit field of a first plurality of bits representing a mantissa of a floating point number and a second bit field of a second plurality of bits representing an exponent of the floating point number. The first plurality of bits is partitioned into a plurality of regions, each of the plurality of regions comprises more than one bit of the first plurality of bits. A leading zero anticipator or other type of leading bit indication circuit is coupled to each region and determines a position of a leading bit of the first plurality of bits. A normalizer is coupled to receive a region of the plurality of regions that contains the leading bit, the normalizer may normalize or denormalize the region to produce a normalized or denormalized floating point number.

Abstract: Method of identification and quantitative analysis of primary and/or secondary amine(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said amine with a stable isotope labeled reagent, and is added to a sample containing said amine. Said amine in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said amine are made from a plot of ion ratio of said converted amine to said internal standard versus amine concentration.

Abstract: Method of identification and quantitative analysis of primary and/or secondary amine(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said amine with a stable isotope labeled reagent, and is added to a sample containing said amine. Said amine in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said amine are made from a plot of ion ratio of said converted amine to said internal standard versus amine concentration.

Abstract: Method of identification and quantitative analysis of primary and/or secondary amine(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said amine with a stable isotope labeled reagent, and is added to a sample containing said amine. Said amine in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said amine are made from a plot of ion ratio of said converted amine to said internal standard versus amine concentration.

Abstract: Method of identification and quantitative analysis of primary and/or secondary amine(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said amine with a stable isotope labeled reagent, and is added to a sample containing said amine. Said amine in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said amine are made from a plot of ion ratio of said converted amine to said internal standard versus amine concentration.

Abstract: An on-chip silicon-based optical coupler used to guide light from an optical fiber to a waveguide. The incoming wave is confined vertically by stacks of graded index materials. In the lateral direction, a linear taper formed by etched holes or trenches confines the wave.

Abstract: Method of automated metabolic stability analysis of library of compounds by mass spectrometry using stable isotope labeled internal standards is provided. Said internal standards are prepared in situ by reaction of an authentic sample of said library compounds with a stable isotope labeled reagent. In an automated fashion, cytochrome P450 enzyme systems are added to said library compounds; said reactions are terminated after certain periods of time by addition of an organic solvent containing equal amounts of said labeled internal standards; said terminated enzyme reactions are treated with a non-labeled version of said stable isotope labeled reagent to convert remaining library compounds to compounds of identical structures, except the labeled atoms, as those of said labeled internal standards; said conversion reactions are extracted and the extracts are analyzed by isotope dilution mass spectrometry to determine the percentage of library compounds remaining after enzyme reactions.

Abstract: Method of identification and quantitative analysis of carboxylic acid (s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said carboxylic acid with a stable isotope labeled reagent, and is added to a sample containing said carboxylic acid. Said carboxylic acid in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said carboxylic acid are made from a plot of ion ratio of said converted carboxylic acid to said internal standard versus carboxylic acid concentration.

Abstract: Method of identification and quantitative analysis of aldehyde(s) and/or ketone(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said aldehyde(s) and/or ketone(s) with a stable isotope labeled reagent, and is added to a sample containing said aldehyde(s) and/or ketone(s). Said aldehyde(s) and/or ketone(s) in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said aldehyde(s) and/or ketone(s) are made from a plot of ion ratio of said converted aldehyde and/or ketone to said internal standard versus aldehyde and/or ketone concentration.

Abstract: Method of identification and quantitative analysis of alcohol(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said alcohol with a stable isotope labeled reagent, and is added to a sample containing said alcohol. Said alcohol in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said alcohol are made from a plot of ion ratio of said converted alcohol to said internal standard versus alcohol concentration.

Abstract: Method of identification and quantitative analysis of primary and/or secondary amine(s) in a sample by mass spectrometry using stable isotope labeled internal standard is provided. Said internal standard is prepared by reaction of an authentic sample of said amine with a stable isotope labeled reagent, and is added to a sample containing said amine. Said amine in said sample is then quantitatively converted to a chemical compound of identical structure, except the stable isotope atoms, as that of said internal standard using a non-labeled reagent. Said sample is then extracted and the extract is analyzed by mass spectrometry. Identification and quantification of said amine are made from a plot of ion ratio of said converted amine to said internal standard versus amine concentration.

Abstract: An on-chip silicon-based optical coupler used to guide light from an optical fiber to a waveguide. The incoming wave is confined vertically by stacks of graded index materials. In the lateral direction, a linear taper formed by etched holes or trenches confines the wave.