Patents by Inventor Trissa BORGSCHULTE

Trissa BORGSCHULTE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • STABLE TARGETED INTEGRATION
    Publication number: 20230374490
    Abstract: Methods for integrating exogenous sequences in genomic loci, wherein the integration is stable and the exogenous sequence can function predictably and reliably.
    Type: Application
    Filed: December 14, 2022
    Publication date: November 23, 2023
    Inventors: Natalie Sealover, Scott Bahr, Michael Johns, Trissa Borgschulte, Henry George, Kevin J. Kayser
  • STABLE TARGETED INTEGRATION
    Publication number: 20220195465
    Abstract: Methods for integrating exogenous sequences in genomic loci, wherein the integration is stable and the exogenous sequence can function predictably and reliably.
    Type: Application
    Filed: April 20, 2020
    Publication date: June 23, 2022
    Inventors: Scott Bahr, Michael Johns, James Ravellette, Joaquina Mascarenhas, Trissa Borgschulte
  • STABLE TARGETED INTEGRATION
    Publication number: 20210309988
    Abstract: Methods for integrating exogenous sequences in genomic loci, wherein the integration is stable and the exogenous sequence can function predictably and reliably.
    Type: Application
    Filed: February 6, 2018
    Publication date: October 7, 2021
    Inventors: Natalie Sealover, Scott Bahr, Michael Johns, Trissa Borgschulte, Henry George, Kevin J. Kayser
  • ENGINEERED CELLS WITH MODIFIED HOST CELL PROTEIN PROFILES
    Publication number: 20210238628
    Abstract: Mammalian cell lines genetically engineered to have reduced or eliminated expression of specific host cell proteins, and methods for using the engineered mammalian cell lines for the production of recombinant proteins having low levels of residual host cell protein contamination.
    Type: Application
    Filed: May 3, 2019
    Publication date: August 5, 2021
    Inventors: Joaquina Mascarenhas, Trissa Borgschulte, Kevin Kayser
  • PRODUCING RECOMBINANT PROTEINS WITH REDUCED LEVELS OF HOST CELL PROTEINS
    Publication number: 20210238222
    Abstract: Processes for producing recombinant proteins having low levels of residual host cell proteins. The processes comprise utilizing engineered host cell lines in which specific host cell proteins are tagged with purification tags, wherein the purification tags can be used to remove those specific host cell proteins from the recombinant proteins.
    Type: Application
    Filed: May 3, 2019
    Publication date: August 5, 2021
    Inventors: Trissa Borgschulte, Joaquina Mascarenhas, Martin Zillmann, Frank Swartzwelder, Kevin Kayser
  • TARGETED INTEGRATION
    Publication number: 20160145645
    Abstract: The present disclosure encompasses an isolated cell comprising an exogenous nucleic acid sequence located within or proximal to a predetermined genomic locus, wherein the exogenous nucleic acid sequence comprises at least one recognition sequence which can be exploited by one or more polynucleotide modification enzymes for targeted integration of a recombinant protein. The disclosure further provides methods for preparing such cells, and methods for retargeting such cells for the production of recombinant proteins, and kits for the same.
    Type: Application
    Filed: June 19, 2014
    Publication date: May 26, 2016
    Applicant: Sigma-Aldrich Co. LLC
    Inventors: Scott BAHR, Trissa BORGSCHULTE, Kevin KAYSER