Abstract: A pouched product adapted for release of a releasable component therefrom is provided herein. The pouched product can include a water-permeable fabric pouch formed so as to define a cavity therein, and a composition contained within the cavity of the water-permeable fabric pouch, the composition including one or more releasable components that are released from the composition under mouth conditions and that are capable of movement through the water-permeable fabric pouch. The composition includes nicotine and at least one particulate non-tobacco material. The pouched product also includes at least one capsule contained within the cavity of the water-permeable fabric pouch, the capsule having a capsule wall surrounding an inner payload comprising at least one botanical.

Abstract: Occlusive implants are provided with various embodiments of active and/or passive release structures. Systems for delivering the occlusive implants as well as methods for making and delivering the implants are also provided.

Abstract: Occlusive implants are provided with various embodiments of active and/or passive release structures. Systems for delivering the occlusive implants as well as methods for making and delivering the implants are also provided.

Abstract: Occlusive implants are provided with various embodiments of active and/or passive release structures. Systems for delivering the occlusive implants as well as methods for making and delivering the implants are also provided.

Abstract: Occlusive implants are provided with various embodiments of active and/or passive release structures. Systems for delivering the occlusive implants as well as methods for making and delivering the implants are also provided.

Abstract: An electrode sealing assembly for use in combination with an electrosurgical instrument includes first and second jaw members which are movable from a first, spaced-apart position to a second position to grasp tissue. Each of the jaw members includes an insulative housing, a thermally conductive, electrically non-conductive material and a sealing plate. The insulative housing has a series of electromechanical interfaces which mate with a corresponding series of electromechanical interfaces which extend from the sealing plate such that the sealing plates are a capable of conducting bipolar energy through tissue held between the jaw members. The thermally conductive, configured to encapsulate and secure the sealing plate to the insulative housing.

Abstract: An anastomosis device for use in coupling an end of a graft vessel to a side of a target vessel. The target vessel has an opening formed in a side wall thereof for insertion of the device. The device comprises a tubular member, at least a portion thereof being radially compressible to a compressed state for insertion of the tubular member into the opening in the target vessel and expandable from the compressed state to an expanded state for engagement of an inner graft vessel surface with an inner surface of the target vessel after insertion of the tubular member into the opening in the side wall of the target vessel. The compressible portion of the tubular member has an inner surface and an outer surface defining a wall thickness therebetween. The wall thickness of the compressible portion in its compressed state is less than the wall thickness of the compressible portion in its expanded state.

Abstract: An electrode sealing assembly for use with an electrosurgical instrument for sealing tissue includes first and second jaw members which are movable from a first position in spaced relation relative to one another to at least one second position for grasping tissue. The jaw members include electrically conductive sealing plates designed to selectively transmit electrosurgical energy to tissue disposed between the sealing plates. The jaw members also include a thermoelectric cooling plate having a first surface in direct contact with an outer surface of the sealing plate. The thermoelectric cooling plate includes first and second electrical connections on opposite sides of the jaw member. The first connection is configured to selectively transmit a first electrical potential and the second connection is configured to selectively transmit a second electrical potential such that heat generated by the sealing plates is transferred away from the tissue via the thermoelectric cooling plate.

Abstract: An electrode sealing assembly for use in combination with an electrosurgical instrument includes first and second jaw members which are movable from a first, spaced-apart position to a second position to grasp tissue. Each of the jaw members includes an insulative housing, a thermally conductive, electrically non-conductive material and a sealing plate. The insulative housing has a series of electromechanical interfaces which mate with a corresponding series of electromechanical interfaces which extend from the sealing plate such that the sealing plates are a capable of conducting bipolar energy through tissue held between the jaw members. The thermally conductive, electrically non-conductive material is configured to encapsulate and secure the sealing plate to the insulative housing.

Abstract: A perfusion-occlusion catheter provides an occluded region in a vessel to facilitate, for example, an anastomosis in the region, while providing a path for perfusing fluid (blood) through the path for delivery in the vessel downstream from the occluded region. According to one aspect of the invention, at least a portion of the catheter that effects vessel occlusion comprises a shield that when exposed to suture needles or like piercing instruments deflects or resists perforation.

Abstract: An anastomosis device for use in coupling an end of a graft vessel to a side of a target vessel. The target vessel has an opening formed in a side wall thereof for insertion of the device. The device comprises a tubular member, at least a portion thereof being radially compressible to a compressed state for insertion of the tubular member into the opening in the target vessel and expandable from the compressed state to an expanded state for engagement of an inner graft vessel surface with an inner surface of the target vessel after insertion of the tubular member into the opening in the side wall of the target vessel. The compressible portion of the tubular member has an inner surface and an outer surface defining a wall thickness therebetween. The wall thickness of the compressible portion in its compressed state is less than the wall thickness of the compressible portion in its expanded state.

Abstract: A perfusion-occlusion catheter provides an occluded region in a vessel to facilitate, for example, an anastomosis in the region, while providing a path for perfusing fluid (blood) through the path for delivery in the vessel downstream from the occluded region. According to one aspect of the invention, at least a portion of the catheter that effects vessel occlusion comprises a shield that when exposed to suture needles or like piercing instruments deflects or resists perforation.

Abstract: The present invention is directed to intraluminal shunt devices and methods of their use for delivering a drug or other fluid to a target vessel of a patient while also maintaining perfusion of blood through the vessel to reduce ischemia downstream of the vessel. The intraluminal shunt devices may generally include a primary elongate tubular member that is sized and dimensioned to be inserted into the target vessel, such as the right coronary artery. The primary tubular member includes at least one inner lumen which permits blood perfusion through the vessel. At least one secondary tubular member is provided which is in fluid communication with the primary tubular member. The secondary tubular member may be configured for drug or fluid delivery through the primary tubular member and into the vessel in either an anterograde or retrograde direction.

Abstract: A sternal closure device comprising first and second clamps. The first and second clamps have a generally tubular portion and the second clamp has a portion that is slidably receivable in the tubular portion, and a lock configured to retain said second clamp within said first clamp. A surgical instrument for laterally moving opposed sternal clamps toward one another is also disclosed. The instrument comprises first and second grasping members generally linearly slidably coupled to one another.