Patents by Inventor Troy Harasym

Troy Harasym has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions for delivery of drug combinations
    Patent number: 10722464
    Abstract: Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.
    Type: Grant
    Filed: July 27, 2018
    Date of Patent: July 28, 2020
    Assignee: Celator Pharmaceuticals, Inc.
    Inventors: Paul Tardi, Troy Harasym, Murray Webb, Clifford Shew, Andrew Janoff, Lawrence Mayer, Marcel Bally
  • COMPOSITIONS FOR DELIVERY OF DRUG COMBINATIONS
    Publication number: 20180338917
    Abstract: Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.
    Type: Application
    Filed: July 27, 2018
    Publication date: November 29, 2018
    Inventors: Paul TARDI, Troy HARASYM, Murray WEBB, Clifford SHEW, Andrew JANOFF, Lawrence MAYER, Marcel BALLY
  • Compositions for delivery of drug combinations
    Patent number: 10058507
    Abstract: Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.
    Type: Grant
    Filed: January 7, 2016
    Date of Patent: August 28, 2018
    Assignee: CELATOR PHARMACEUTICALS, INC.
    Inventors: Paul Tardi, Troy Harasym, Murray Webb, Clifford Shew, Andrew Janoff, Lawrence Mayer, Marcel Bally
  • COMPOSITIONS FOR DELIVERY OF DRUG COMBINATIONS
    Publication number: 20160113871
    Abstract: Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.
    Type: Application
    Filed: January 7, 2016
    Publication date: April 28, 2016
    Applicant: CELATOR PHARMACEUTICALS, INC.
    Inventors: Paul Tardi, Troy Harasym, Murray Webb, Clifford Shew, Andrew Janoff, Lawrence Mayer, Marcel Bally
  • Compositions for delivery of drug combinations
    Patent number: 9271931
    Abstract: Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.
    Type: Grant
    Filed: April 16, 2004
    Date of Patent: March 1, 2016
    Assignee: CELATOR PHARMACEUTICALS, INC.
    Inventors: Paul Tardi, Troy Harasym, Murray Webb, Clifford Shew, Lawrence Mayer, Andrew Janoff, Marcel Bally
  • Liposomal formulations of anthracycline agents and cytidine analogs
    Patent number: 8431806
    Abstract: Compositions which comprise an anthracycline agent, and a cytidine analog are encapsulated in liposomal carriers. The preferred anthracycline agent is selected from the group of daunorubicin, doxorubicin, and idarubicin, while the preferred cytidine analog is selected from the group of cytarabine, gemcitabine, or 5-azacytidine. The combination of the anthracycline agent and cytidine analog encapsulated in said liposomal carriers are useful in achieving a drug retention and a sustained drug release for each therapeutic agent.
    Type: Grant
    Filed: September 20, 2011
    Date of Patent: April 30, 2013
    Assignee: Celator Pharmaceuticals, Inc.
    Inventors: Lawrence Mayer, Sharon Johnstone, Troy Harasym
  • HIGH EFFICIENCY ENCAPSULATION OF CHARGED THERAPEUTIC AGENTS IN LIPID VESICLES
    Publication number: 20120114831
    Abstract: Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino lipid and a lipid such as a PEG- or Polyamide oligomer-modified lipid is combined with a buffered aqueous solution of a charged therapeutic agent, for example polyanionic nucleic acids, to produce particles in which the therapeutic agent is encapsulated in a lipid vesicle. Surface charges on the lipid particles are at least partially neutralized to provide surface-neutralized lipid-encapsulated compositions of the therapeutic agents. The method permits the preparation of compositions with high ratios of therapeutic agent to lipid and with encapsulation efficiencies in excess of 50%.
    Type: Application
    Filed: August 1, 2011
    Publication date: May 10, 2012
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Sean C. Semple, Sandra K. Klimuk, Troy Harasym, Michael J. Hope, Steven M. Ansell, Pieter Cullis, Peter Scherrer, Dan Debeyer
  • LIPOSOMAL FORMULATIONS OF ANTHRACYCLINE AGENTS AND CYTIDINE ANALOGS
    Publication number: 20120009252
    Abstract: Compositions which comprise an anthracycline agent, and a cytidine analog are encapsulated in liposomal carriers. The preferred anthracycline agent is selected from the group of daunorubicin, doxorubicin, and idarubicin, while the preferred cytidine analog is selected from the group of cytarabine, gemcitabine, or 5-azacytidine. The combination of the anthracycline agent and cytidine analog encapsulated in said liposomal carriers are useful in achieving a drug retention and a sustained drug release for each therapeutic agent.
    Type: Application
    Filed: September 20, 2011
    Publication date: January 12, 2012
    Applicant: CELATOR PHARMACEUTICALS, INC.
    Inventors: Lawrence MAYER, Sharon Johnstone, Troy Harasym
  • Lipid-encapsulated polyanionic nucleic acid
    Patent number: 8021686
    Abstract: Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino lipid and a lipid such as a PEG- or Polyamide oligomer-modified lipid is combined with a buffered aqueous solution of a charged therapeutic agent, for example polyanionic nucleic acids, to produce particles in which the therapeutic agent is encapsulated in a lipid vesicle. Surface charges on the lipid particles are at least partially neutralized to provide surface-neutralized lipid-encapsulated compositions of the therapeutic agents. The method permits the preparation of compositions with high ratios of therapeutic agent to lipid and with encapsulation efficiencies in excess of 50%.
    Type: Grant
    Filed: February 8, 2008
    Date of Patent: September 20, 2011
    Assignee: The University of British Columbia
    Inventors: Sean C. Semple, Sandra K. Klimuk, Troy Harasym, Michael J. Hope, Steven M. Ansell, Pieter R. Cullis, Peter Scherrer, Dan Debeyer
  • Liposomal formulations of anthracycline agents and cytidine analogs
    Patent number: 8022279
    Abstract: Compositions which comprise an anthracycline agent, and a cytidine analog are encapsulated in liposomal carriers. The preferred anthracycline agent is selected from the group of daunorubicin, doxorubicin, and idarubicin, while the preferred cytidine analog is selected from the group of cytarabine, gemcitabine, or 5-azacytidine. The combination of the anthracycline agent and cytidine analog encapsulated in said liposomal carriers are useful in achieving a drug retention and a sustained drug release for each therapeutic agent.
    Type: Grant
    Filed: April 22, 2005
    Date of Patent: September 20, 2011
    Assignee: Celator Pharmaceuticals, Inc.
    Inventors: Lawrence Mayer, Sharon Johnstone, Troy Harasym
  • Compositions for delivery of drug combinations
    Patent number: 7850990
    Abstract: Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.
    Type: Grant
    Filed: April 16, 2003
    Date of Patent: December 14, 2010
    Assignee: Celator Pharmaceuticals, Inc.
    Inventors: Paul Tardi, Troy Harasym, Murray Webb, Clifford Shew, Marcel Bally, Lawrence Mayer, Andrew Janoff
  • COMBINATION FORMULATIONS OF CYTIDINE ANALOGS AND PLATINUM AGENTS
    Publication number: 20090074848
    Abstract: Compositions which comprise delivery vehicles having stably associated therewith a cytidine analog and a platinum agent are useful in achieving enhanced therapeutic effects when combinations of these drugs are administered.
    Type: Application
    Filed: September 19, 2006
    Publication date: March 19, 2009
    Inventors: Sharon Johnstone, Pierrot Harvie, Paul Tardi, Troy Harasym, Lawrence Mayer
  • HIGH EFFICIENCY ENCAPSULATION OF CHARGED THERAPEUTIC AGENTS IN LIPID VESICLES
    Publication number: 20080200417
    Abstract: Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino lipid and a lipid such as a PEG- or Polyamide oligomer-modified lipid is combined with a buffered aqueous solution of a charged therapeutic agent, for example polyanionic nucleic acids, to produce particles in which the therapeutic agent is encapsulated in a lipid vesicle. Surface charges on the lipid particles are at least partially neutralized to provide surface-neutralized lipid-encapsulated compositions of the therapeutic agents. The method permits the preparation of compositions with high ratios of therapeutic agent to lipid and with encapsulation efficiencies in excess of 50%.
    Type: Application
    Filed: February 8, 2008
    Publication date: August 21, 2008
    Applicant: THE UNIVERSITY OF BRITISH COLUMBIA
    Inventors: Sean C. Semple, Sandra K. Klimuk, Troy Harasym, Michael J. Hope, Steven M. Ansell, Pieter Cullis, Peter Scherrer, Dan Debeyer
  • COMPOSITIONS FOR DELIVERY OF DRUG COMBINATIONS
    Publication number: 20080075762
    Abstract: Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.
    Type: Application
    Filed: August 20, 2007
    Publication date: March 27, 2008
    Inventors: Paul Tardi, Troy Harasym, Murray Webb, Clifford Shew
  • Lipid-encapsulated polyanionic nucleic acid
    Patent number: 7341738
    Abstract: Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino lipid and a lipid such as a PEG- or Polyamide oligomer-modified lipid is combined with a buffered aqueous solution of a charged therapeutic agent, for example polyanionic nucleic acids, to produce particles in which the therapeutic agent is encapsulated in a lipid vesicle. Surface charges on the lipid particles are at least partially neutralized to provide surface-neutralized lipid-encapsulated compositions of the therapeutic agents. The method permits the preparation of compositions with high ratios of therapeutic agent to lipid and with encapsulation efficiencies in excess of 50%.
    Type: Grant
    Filed: September 9, 2003
    Date of Patent: March 11, 2008
    Assignee: The University of British Columbia
    Inventors: Sean C. Semple, Sandra K. Klimuk, Troy Harasym, Michael J. Hope, Steven M. Ansell, Pieter Cullis, Peter Scherrer, Dan Debeyer
  • Compositions for Delivery of Drug Combinations
    Publication number: 20070298092
    Abstract: Compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents, such as antineoplastic agents, are useful in achieving non-antagonistic effects when combinations of drugs are administered.
    Type: Application
    Filed: April 16, 2004
    Publication date: December 27, 2007
    Inventors: Paul Tardi, Troy Harasym, Murray Webb, Clifford Shew, Lawrence Mayer, Andrew Janoff
  • Liposomal Formulations of Anthracycline Agents and Cytidine Analogs
    Publication number: 20070286897
    Abstract: Compositions which comprise an anthracycline agent, and a cytidine analog are encapsulated in liposomal carriers. The preferred anthracycline agent is selected from the group of daunorubicin, doxorubicin, and idarubicin, while the preferred cytidine analog is selected from the group of cytarabine, gemcitabine, or 5-azacytidine. The combination of the anthracycline agent and cytidine analog encapsulated in said liposomal carriers are useful in achieving a drug retention and a sustained drug release for each therapeutic agent.
    Type: Application
    Filed: April 22, 2005
    Publication date: December 13, 2007
    Applicant: CELATOR PHARMACEUTICALS, INC.
    Inventors: Lawrence Mayer, Sharon Johnstone, Troy Harasym
  • Compositions for delivery of drug combinations
    Publication number: 20070148255
    Abstract: Methods to prepare compositions which comprise delivery vehicles having stably associated therewith non-antagonistic combinations of two or more agents. The compositions exhibit non-antagonistic effects when combinations of drugs are administered.
    Type: Application
    Filed: January 31, 2007
    Publication date: June 28, 2007
    Inventors: Paul Tardi, Troy Harasym, Murray Webb, Clifford Shew, Marcel Bally, Lawrence Mayer, Andrew Janoff, Trevor Shew, Dominic Shew
  • Compositions for treating drug resistance
    Publication number: 20060216341
    Abstract: Delivery vehicle compositions having stably associated therewith at least one therapeutic agent and at least one drug resistance modulator are useful in achieving a biologic effect to a drug resistance target.
    Type: Application
    Filed: April 2, 2004
    Publication date: September 28, 2006
    Inventors: Paul Tardi, Troy Harasym, Murray Webb, Clifford Shew
  • High efficiency encapsulation of charged therapeutic agents in lipid vesicles
    Publication number: 20050255153
    Abstract: Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino lipid and a lipid such as a PEG- or Polyamide oligomer-modified lipid is combined with a buffered aqueous solution of a charged therapeutic agent, for example polyanionic nucleic acids, to produce particles in which the therapeutic agent is encapsulated in a lipid vesicle. Surface charges on the lipid particles are at least partially neutralized to provide surface-neutralized lipid-encapsulated compositions of the therapeutic agents. The method permits the preparation of compositions with high ratios of therapeutic agent to lipid and with encapsulation efficiencies in excess of 50%.
    Type: Application
    Filed: September 9, 2003
    Publication date: November 17, 2005
    Inventors: Sean Semple, Sandra Klimuk, Troy Harasym, Michael Hope, Steven Ansell, Pieter Cullis, Peter Scherrer, Dan Debeyer