Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: A non-irritating topical composition for moisturizing and cleansing the skin includes: a mixture of moisturizers and conditioning agents; a mixture of surfactants; a mixture of anti-irritant agents; and a mixture of hydrating and rejuvenation agents, in an aqueous vehicle. At least one ingredient in each of the ingredient groups consisting of moisturizers and conditioning agents, surfactants, anti-irritant agents, and hydrating and rejuvenation agents is plant-derived. The composition is essentially free from any synthetic additives or by-products. The composition has a pH in the range of 5.0-8.0.

Abstract: An improved casing cutter apparatus and method of use are provided for cutting one or more casing strings positioned within a subterranean wellbore during the ‘cut-and-cap’ stage of the wellbore abandonment process. In some embodiments, the apparatus may comprise a cutting attachment operably coupled to at least one mobile power source located at or near the surface of the wellbore.

Abstract: A composition for treating dry skin includes therapeutically active concentrations of one or more skin protecting lipids in an oleaginous base. The skin protecting lipids can include a sphingolipid and at least one oil. The composition is intended for application on the skin surrounding the eyes. The composition is configured to form a protective, occlusive layer that can moisturize the skin and reduce inflammation and itching without stinging, burning, or stripping the skin. According to an exemplary embodiment, the composition is formulated as a high viscosity ointment or gel.

Abstract: A topical formulation, comprising: an ointment base; and a mixture of active pharmaceutical ingredients (APIs) contained in the ointment base, the mixture of APIs consisting of: Metronidazole; Ivermectin; and Melaleuca alternifolia (tea tree) oil. The APIs are about 0.12%-6% w/w and the ointment base is about 94% to 99% w/w of the topical formulation. The formulation can further include enhancers for the APIs, such as, moisturizers and anti-oxidants. The formulation is configured as an anti-parasitic, anti-inflammatory and anti-microbial formulation.

Abstract: A composition for treating dry skin includes therapeutically active concentrations of one or more skin protecting lipids in an oleaginous base. The skin protecting lipids can include a sphingolipid and at least one oil. The composition is intended for application on the skin surrounding the eyes. The composition is configured to form a protective, occlusive layer that can moisturize the skin and reduce inflammation and itching without stinging, burning, or stripping the skin. According to an exemplary embodiment, the composition is formulated as a high viscosity ointment or gel.

Abstract: The present invention relates to compounds of formula (I): or pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising these compounds, as well as methods and uses of these compounds in the treatment of diseases.

Abstract: An anti-allergenic product having: at least 0.01% w/w of a plant extract, wherein the plant extract is selected from the group consisting of Camellia sinensis leaf extract, Melaleuca alternifolia leaf oil, and mixtures thereof; an amphiphilic preservative, and a glycolipid. The eyelid cleansing composition is configured to relieve redness, discomfort and irritation in and around the eyelid.

Abstract: The present invention relates to compounds of formula (I) as activators of glucagon-like peptide 1 (GLP1) receptor for the treatment of obesity, type 2 diabetes mellitus, insulin resistance, hyperinsulinemia, glucose intolerance, hyperglycemia, one or more diabetic complications, diabetic nephropathy, dyslipidemia, non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), hypertension, atherosclerosis, peripheral arterial disease, stroke, cardiomyopathy, atrial fibrillation, heart failure, coronary heart disease and neuropathy. Preferred compounds are e.g. 2-((4-((S)-2-(4-chloro-2-fluorophenyl)-2-methylbenzo[d][1,3]dioxol-4-yl)piperidin-1-yl)methyl)-1-(((S)-oxetan-2-yl)methyl)-1H-imidazole derivatives and similar compounds, such as e.g. C-1, C-2, C-3, C-4 and other compounds.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: An improved casing cutter apparatus and method of use are provided for cutting one or more casing strings positioned within a subterranean wellbore during the ‘cut-and-cap’ stage of the wellbore abandonment process. In some embodiments, the apparatus may comprise a cutting attachment operably coupled to at least one mobile power source located at or near the surface of the wellbore.

Abstract: A non-irritating topical composition for moisturizing and cleansing the skin includes: a mixture of moisturizers and conditioning agents; a mixture of surfactants; a mixture of anti-irritant agents; and a mixture of hydrating and rejuvenation agents, in an aqueous vehicle. At least one ingredient in each of the ingredient groups consisting of moisturizers and conditioning agents, surfactants, anti-irritant agents, and hydrating and rejuvenation agents is plant-derived. The composition is essentially free from any synthetic additives or by-products. The composition has a pH in the range of 5.0-8.0.

Abstract: A composition for treating dry skin includes therapeutically active concentrations of one or more skin protecting lipids in an oleaginous base. The skin protecting lipids can include a sphingolipid and at least one oil. The composition is intended for application on the skin surrounding the eyes. The composition is configured to form a protective, occlusive layer that can moisturize the skin and reduce inflammation and itching without stinging, burning, or stripping the skin. According to an exemplary embodiment, the composition is formulated as a high viscosity ointment or gel.

Abstract: A topical skin moisturizing composition comprising: (a) one or more phospholipids; (b) a plurality of demulcents; (c) one or more polymeric moisturizing agents; (d) one or more preservatives; (e) one or more vitamins; and (f) an aqueous vehicle. The moisturizing composition can have an osmolality in the range of 80 mOsm/kg to 500 mOsm/kg. The composition is configured for use on the face and, particularly for application on and around the delicate eye area including the eyelids.

Abstract: The invention involves forceps having rounded grasping tips. The rounded tips are configured to avoid puncturing an amniotic membrane during insertion over an ocular surface for the treatment of dry eye disease and inflammation of the eyes and to avoid injuring the conjunctiva during removal of an amniotic membrane from the ocular surface. The forceps have grasping tips at its distal end, wherein one of the grasping tips has a notch on its inside surface. The dimensions of the notch are configured to permit an eye doctor to securely and safely grasp a lip of an amniotic membrane insert for better insertion and removal from an ocular surface.

Abstract: The invention involves forceps having rounded grasping tips. The rounded tips are configured to avoid puncturing an amniotic membrane during insertion over an ocular surface for the treatment of dry eye disease and inflammation of the eyes and to avoid injuring the conjunctiva during removal of an amniotic membrane from the ocular surface. The forceps have grasping tips at its distal end, wherein one of the grasping tips has a notch on its inside surface. The dimensions of the notch are configured to permit an eye doctor to securely and safely grasp a lip of an amniotic membrane insert for better insertion and removal from an ocular surface.

Abstract: A first ocular treatment kit comprises one or more sealed wrappers containing an applicator and a first ocular composition. The applicator includes a shaft and a swab, wherein the swab is coupled to a first end of the shaft. The swab is saturated with the first ocular composition inside the wrapper. The first ocular composition comprises polyaminopropyl biguanide, 1,2 hexanediol and caprylyl glycol. A second ocular treatment kit comprises a first sealed wrapper and a second sealed wrapper. The first sealed wrapper contains an applicator while the second sealed wrapper contains a second ocular composition. The second ocular composition comprises tea tree oil, tea tree oil, sea buckthorn oil and a medium chain triglyceride.

Abstract: The disclosed compounds relate to treatments and therapies for protein kinase-associated disorders. There is also a need for compounds useful in the treatment or prevention or amelioration of one or more symptoms of cancer, transplant rejections, and autoimmune diseases. Furthermore, there is a need for methods for modulating the activity of protein kinases, such as CDK1, CDK2, CDK4, CDK5, CDK6, CDK7, CDK8 and CDK9, using the compounds provided herein.

Abstract: An anti-allergenic product consists of: (A) a substrate; and (B) an eyelid cleansing composition comprising: at least 0.01% w/w of a plant extract, wherein the plant extract is selected from the group consisting of Camellia sinensis leaf extract, Melaleuca alternifolia leaf oil, and mixtures thereof; and phytosphingosine hydrochloride. The substrate can be pre-moistened with the composition. The eyelid cleansing composition is configured to relieve redness, discomfort and irritation in and around the eyelid.

Abstract: Compositions and methods for treating skin redness. According to an embodiment, the invention is a topical skin care composition having a dermatologically acceptable vehicle, such as, water and a plurality of ingredients dissolved in the vehicle. The ingredients include: a blend of natural oils; a plurality of vitamins; and 0.1-1 wt % salicyloyl phytosphingosine. The composition is unsuitable for application on the eyelids or eye area. The blend of natural oils includes: Aloe barbadensis leaf juice extract; Cocos nucifera (coconut oil); hydrolyzed glycosaminoglycans; and caprylic/capric triglycerides. The plurality of vitamins is selected from a group consisting of vitamin C, vitamin E, salts/derivatives of vitamin C and vitamin E, and mixtures thereof. In one aspect, the plurality of vitamins includes: sodium ascorbyl phosphate; disodium lauriminodipropionate tocopheryl phosphate; and jojoba oil.