Abstract: Devices and methods are directed to altering gaseous flow within a lung to improve the expiration cycle of, for instance, an individual having chronic obstructive pulmonary disease. More particularly, methods and devices are disclosed that inhibit closure of channels surgically created through an airway wall such that air is able to pass directly out of the lung tissue to facilitate both the exchange of oxygen ultimately into the blood and/or to decompress hyper-inflated lungs. Devices, instruments, medicine, bioactive agents, or combinations thereof serve to maintain the patency of the surgically created channels. In one embodiment of the present invention, a conduit includes a bioactive coating that inhibits tissue overgrowth when the conduit is deployed in a surgically created channel. Still other methods and devices are described that serve to maintain surgically created channels.